| UniProt ID | MOBP_RAT | |
|---|---|---|
| UniProt AC | Q63327 | |
| Protein Name | Myelin-associated oligodendrocyte basic protein | |
| Gene Name | Mobp | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 170 | |
| Subcellular Localization | Cytoplasm, perinuclear region . Present in the major dense line of CNS myelin. Isoform 5 may be differentially localized in the oligodendrocytes or perinuclear region. Isoform 2, 4, 5 and 6 are highly enriched in myelin. Isoform 1 and 3 are not enric | |
| Protein Description | May play a role in compacting or stabilizing the myelin sheath, possibly by binding the negatively charged acidic phospholipids of the cytoplasmic membrane.. | |
| Protein Sequence | MSQKVAKEGPRLSKNQKFSEHFSIHCCPPFTFLNSKREIVDRKYSICKSGCFYQKKEEDWICCACQKTSRRATSPQKPKHQPAASPVVVRAPPAKPKSPPRPAKPRSPPIPAKPRSPSRTERQPRPRPEVRPPPAKQKPPQKSKQPARSSPLRGPGTSRGGSPTRAPRFW | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 36 | Acetylation | PFTFLNSKREIVDRK CCHHCCCCHHHHHHH | 53.64 | 14497345 | |
| 74 (in isoform 5) | Phosphorylation | - | 25.09 | 22673903 | |
| 74 | Phosphorylation | KTSRRATSPQKPKHQ CCCCCCCCCCCCCCC | 25.09 | 27115346 | |
| 76 (in isoform 5) | Phosphorylation | - | 74.56 | 22673903 | |
| 77 (in isoform 5) | Phosphorylation | - | 60.46 | 22673903 | |
| 85 | Phosphorylation | PKHQPAASPVVVRAP CCCCCCCCCEEEECC | 21.97 | 30411139 | |
| 98 | Phosphorylation | APPAKPKSPPRPAKP CCCCCCCCCCCCCCC | 48.98 | 25403869 | |
| 104 | Acetylation | KSPPRPAKPRSPPIP CCCCCCCCCCCCCCC | 43.58 | 22902405 | |
| 104 | Ubiquitination | KSPPRPAKPRSPPIP CCCCCCCCCCCCCCC | 43.58 | - | |
| 107 | Phosphorylation | PRPAKPRSPPIPAKP CCCCCCCCCCCCCCC | 43.48 | 25403869 | |
| 113 | Ubiquitination | RSPPIPAKPRSPSRT CCCCCCCCCCCCCCC | 35.29 | - | |
| 116 | Phosphorylation | PIPAKPRSPSRTERQ CCCCCCCCCCCCCCC | 35.44 | 25403869 | |
| 118 | Phosphorylation | PAKPRSPSRTERQPR CCCCCCCCCCCCCCC | 53.75 | 22673903 | |
| 120 | Phosphorylation | KPRSPSRTERQPRPR CCCCCCCCCCCCCCC | 39.60 | 25403869 | |
| 149 | Phosphorylation | KSKQPARSSPLRGPG CCCCCCCCCCCCCCC | 38.11 | 22673903 | |
| 150 | Phosphorylation | SKQPARSSPLRGPGT CCCCCCCCCCCCCCC | 23.54 | 25403869 | |
| 157 | Phosphorylation | SPLRGPGTSRGGSPT CCCCCCCCCCCCCCC | 20.55 | 25403869 | |
| 158 | Phosphorylation | PLRGPGTSRGGSPTR CCCCCCCCCCCCCCC | 34.54 | 25403869 | |
| 162 | Phosphorylation | PGTSRGGSPTRAPRF CCCCCCCCCCCCCCC | 26.39 | 25403869 | |
| 164 | Phosphorylation | TSRGGSPTRAPRFW- CCCCCCCCCCCCCC- | 40.95 | 25403869 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MOBP_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MOBP_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MOBP_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MOBP_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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