dbPTM

MNX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MNX1_HUMAN
UniProt AC	P50219
Protein Name	Motor neuron and pancreas homeobox protein 1
Gene Name	MNX1
Organism	Homo sapiens (Human).
Sequence Length	401
Subcellular Localization	Nucleus.
Protein Description	Putative transcription factor involved in pancreas development and function..
Protein Sequence	MEKSKNFRIDALLAVDPPRAASAQSAPLALVTSLAAAASGTGGGGGGGGASGGTSGSCSPASSEPPAAPADRLRAESPSPPRLLAAHCALLPKPGFLGAGGGGGGTGGGHGGPHHHAHPGAAAAAAAAAAAAAAGGLALGLHPGGAQGGAGLPAQAALYGHPVYGYSAAAAAAALAGQHPALSYSYPQVQGAHPAHPADPIKLGAGTFQLDQWLRASTAGMILPKMPDFNSQAQSNLLGKCRRPRTAFTSQQLLELEHQFKLNKYLSRPKRFEVATSLMLTETQVKIWFQNRRMKWKRSKKAKEQAAQEAEKQKGGGGGAGKGGAEEPGAEELLGPPAPGDKGSGRRLRDLRDSDPEEDEDEDDEDHFPYSNGASVHAASSDCSSEDDSPPPRPSHQPAPQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEKSKNFR -------CCCCCCCC	15.34	22814378
22	Phosphorylation	VDPPRAASAQSAPLA CCCCCHHCCCCHHHH	26.34	28634120
25	Phosphorylation	PRAASAQSAPLALVT CCHHCCCCHHHHHHH	31.41	28634120
32	Phosphorylation	SAPLALVTSLAAAAS CHHHHHHHHHHHHHH	20.90	22210691
33	Phosphorylation	APLALVTSLAAAASG HHHHHHHHHHHHHHC	14.45	22210691
39	Phosphorylation	TSLAAAASGTGGGGG HHHHHHHHCCCCCCC	31.96	25022875
41	Phosphorylation	LAAAASGTGGGGGGG HHHHHHCCCCCCCCC	30.11	28634120
51	Phosphorylation	GGGGGGASGGTSGSC CCCCCCCCCCCCCCC	40.82	25022875
52	Ubiquitination	GGGGGASGGTSGSCS CCCCCCCCCCCCCCC	42.75	29967540
54	Phosphorylation	GGGASGGTSGSCSPA CCCCCCCCCCCCCCC	33.18	25022875
55	Phosphorylation	GGASGGTSGSCSPAS CCCCCCCCCCCCCCC	31.80	29802988
57	Phosphorylation	ASGGTSGSCSPASSE CCCCCCCCCCCCCCC	15.93	29802988
59	Phosphorylation	GGTSGSCSPASSEPP CCCCCCCCCCCCCCC	25.79	29802988
62	Phosphorylation	SGSCSPASSEPPAAP CCCCCCCCCCCCCCC	38.32	25022875
63	Phosphorylation	GSCSPASSEPPAAPA CCCCCCCCCCCCCCH	57.12	25022875
77	Phosphorylation	ADRLRAESPSPPRLL HHHHHCCCCCCHHHH	29.68	29255136
79	Phosphorylation	RLRAESPSPPRLLAA HHHCCCCCCHHHHHH	57.74	29255136
130	Ubiquitination	AAAAAAAAAAAAGGL HHHHHHHHHHHHCCH	7.91	29967540
215	Methylation	FQLDQWLRASTAGMI ECHHHHHHHHHCCCC	24.43	115483591
225	Ubiquitination	TAGMILPKMPDFNSQ HCCCCCCCCCCCCHH	60.67	-
240	Ubiquitination	AQSNLLGKCRRPRTA HHHHHHHCCCCCCCC	25.25	29967540
264	Ubiquitination	EHQFKLNKYLSRPKR HHHHHHHHHHCCCCH	58.99	29967540
265	Phosphorylation	HQFKLNKYLSRPKRF HHHHHHHHHCCCCHH	14.61	24719451
267	Phosphorylation	FKLNKYLSRPKRFEV HHHHHHHCCCCHHHH	43.37	24719451
276	Phosphorylation	PKRFEVATSLMLTET CCHHHHHHHHHCCHH	27.80	29083192
277	Phosphorylation	KRFEVATSLMLTETQ CHHHHHHHHHCCHHH	11.31	29083192
281	Phosphorylation	VATSLMLTETQVKIW HHHHHHCCHHHHHHH	24.03	29083192
283	Phosphorylation	TSLMLTETQVKIWFQ HHHHCCHHHHHHHHH	33.17	29083192
322	Ubiquitination	GGGGGAGKGGAEEPG CCCCCCCCCCCCCCC	54.35	-
322	Acetylation	GGGGGAGKGGAEEPG CCCCCCCCCCCCCCC	54.35	26051181
342	Ubiquitination	GPPAPGDKGSGRRLR CCCCCCCCCCCCCHH	61.97	29967540
342	Acetylation	GPPAPGDKGSGRRLR CCCCCCCCCCCCCHH	61.97	25953088
389	Phosphorylation	DCSSEDDSPPPRPSH CCCCCCCCCCCCCCC	52.18	26329039

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MNX1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MNX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MNX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MNX1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
176450	Currarino syndrome (CURRAS)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MNX1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND SER-79, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-77 AND SER-79, AND MASSSPECTROMETRY.	18669648 [Abstract]