MLXIP_MOUSE - dbPTM
MLXIP_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MLXIP_MOUSE
UniProt AC Q2VPU4
Protein Name MLX-interacting protein
Gene Name Mlxip {ECO:0000312|MGI:MGI:2141183}
Organism Mus musculus (Mouse).
Sequence Length 917
Subcellular Localization Cytoplasm . Nucleus . Mitochondrion outer membrane . Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial
Protein Description Binds DNA as a heterodimer with MLX and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation..
Protein Sequence MAADVFMCSPRRPRSRGRSVLLKPQVPEDDDDSDTDEPSPPPPSGVATSARAHASAAPLPPRAGPGREEPPRRQQIIHSGHFMVSSPHREHPPKKGYDFDTVNKQTCQTYSFGKTSSCHLSIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRRNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHKDEDLSSLAQDDDMLYWHKHGDGWKTPVPMEEDSLLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIAHLGNADMIQPGLIPLQPNLDFMDTFEPFQDLFSSSRSIFGSMLPPPSSLPAADPSSPPSQGNILPNTALPPASLPNSLITSSAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEPPLSVPQPFLPVFTMTLLSPGPAPAPVPTALPLVPSPAPTLNPPTPPAFLQPQKFAGVSKSTPVITHTASATLTHDASATTFSQNQGLVITAHHPTPSSSPCALALSPVPQPPAVGPPQPHLTFIHPKPVSLTGVRHKQPPKIVPAPKPEPVSLVLKNACIAPAAFSGQPQKVIMTSAPLKREGILASTVSPSNVVIASAAITRASGVTEFLSHSTSSQPSPVSRLFSPSTVQDSLVKGEQVSLHGGSPQVPATGSSRDCPNSGQASPCPSEQSPSPQSPQNNCSGKSTDPKNVAALKNRQKHISAEQKRRFNIRMGFNTLNSLISNNSKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREEIEELNTTIISCQQLLPATGVPVNCRQLDHMRDMFDEYVKSRTLQNWKFWIFSMIIKPLFESFKGMVSTSSLEEFHRTALSWLDQHCSLPVLRPMVLSTLRQLSTTTSILTDPSQLPEQASEAVTRMGKRSGES
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAADVFMCS
------CCCCEEECC		16.63-
9PhosphorylationAADVFMCSPRRPRSR
CCCEEECCCCCCCCC		15.0629514104
19PhosphorylationRPRSRGRSVLLKPQV
CCCCCCCCEEECCCC		21.6825619855
33PhosphorylationVPEDDDDSDTDEPSP
CCCCCCCCCCCCCCC		49.7821082442
35PhosphorylationEDDDDSDTDEPSPPP
CCCCCCCCCCCCCCC		46.3325619855
39PhosphorylationDSDTDEPSPPPPSGV
CCCCCCCCCCCCCCC		48.2521082442
44PhosphorylationEPSPPPPSGVATSAR
CCCCCCCCCCCCCCC		52.2325619855
48PhosphorylationPPPSGVATSARAHAS
CCCCCCCCCCCHHHH		22.1025619855
49PhosphorylationPPSGVATSARAHASA
CCCCCCCCCCHHHHC		13.1525619855
86PhosphorylationSGHFMVSSPHREHPP
CCCEECCCCCCCCCC		17.2028507225
115PhosphorylationQTYSFGKTSSCHLSI
EEECCCCCCCCEEEE		26.6727717184
137PhosphorylationFECMTLAYSGKLVSP
HHHHHHHHCCCCCCC		22.5227717184
213PhosphorylationTEGKYWKSRIEIVIR
CCCCHHHHHHHHHHH		25.0923737553
222PhosphorylationIEIVIREYHKWRTYF
HHHHHHHHHHHHHHH		10.0023737553
640PhosphorylationHSTSSQPSPVSRLFS
CCCCCCCCCCHHCCC		30.2329514104
647PhosphorylationSPVSRLFSPSTVQDS
CCCHHCCCCCHHHCH		23.6428066266
649PhosphorylationVSRLFSPSTVQDSLV
CHHCCCCCHHHCHHC		39.7628066266
650PhosphorylationSRLFSPSTVQDSLVK
HHCCCCCHHHCHHCC		26.1028066266
667PhosphorylationQVSLHGGSPQVPATG
EEECCCCCCCCCCCC		19.42-
682PhosphorylationSSRDCPNSGQASPCP
CCCCCCCCCCCCCCC		19.8830635358
686PhosphorylationCPNSGQASPCPSEQS
CCCCCCCCCCCCCCC		21.1030635358
690PhosphorylationGQASPCPSEQSPSPQ
CCCCCCCCCCCCCCC		55.7925293948
693PhosphorylationSPCPSEQSPSPQSPQ
CCCCCCCCCCCCCCC		24.2425293948
695PhosphorylationCPSEQSPSPQSPQNN
CCCCCCCCCCCCCCC		40.6025293948
698PhosphorylationEQSPSPQSPQNNCSG
CCCCCCCCCCCCCCC		31.6625293948
704PhosphorylationQSPQNNCSGKSTDPK
CCCCCCCCCCCCCHH		51.9125293948
717AcetylationPKNVAALKNRQKHIS
HHHHHHHHHHHHHCC		45.4123806337
724PhosphorylationKNRQKHISAEQKRRF
HHHHHHCCHHHHHHH		26.0229895711
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MLXIP_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MLXIP_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MLXIP_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MLXIP_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MLXIP_MOUSE

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Related Literatures of Post-Translational Modification

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