MKP1_ARATH - dbPTM
MKP1_ARATH - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MKP1_ARATH
UniProt AC Q9C5S1
Protein Name Protein-tyrosine-phosphatase MKP1
Gene Name MKP1
Organism Arabidopsis thaliana (Mouse-ear cress).
Sequence Length 784
Subcellular Localization Cytoplasm, cytosol .
Protein Description Protein-tyrosine-phosphatase that acts as a negative regulator of MPK6 and MPK3 signaling by dephosphorylating and repressing MPK6 and MPK3. Modulates defense response by repressing salicylic acid (SA) production, camalexin biosynthesis and SNC1-mediated responses. Acts as a negative regulator of MPK6-mediated pathogen-associated molecular pattern (PAMP) responses, including MPK6 and MPK3 activation, accumulation of extracellular reactive oxygen species and inhibition of seedling growth. Involved in UV-B stress tolerance. May be involved in salt and genotoxic stress responses..
Protein Sequence MVGREDAMGNDEAPPGSKKMFWRSASWSASRTASQVPEGDEQSLNIPCAISSGPSRRCPAAPLTPRSHHNSKARACLPPLQPLAISRRSLDEWPKAGSDDVGEWPHPPTPSGNKTGERLKLDLSSTQQRVTDKSSGLAKREKIAFFDKECSKVADHIYVGGDAVAKDKSILKNNGITHILNCVGFICPEYFKSDFCYRSLWLQDSPSEDITSILYDVFDYFEDVREQSGRIFVHCCQGVSRSTSLVIAYLMWREGQSFDDAFQYVKSARGIADPNMGFACQLLQCQKRVHAFPLSPTSLLRMYKMSPHSPYDPLHLVPKLLNDPCPGSLDSRGAFIIQLPSAIYIWVGRQCETIMEKDAKAAVCQIARYEKVEAPIMVVREGDEPVYYWDAFASILPMIGGSVIKVQPGDRKVDAYNLDFEIFQKAIEGGFVPTLASSNNEHETHLPARENSWSSLKCKFASRFDKGFRYVSKTPLSRVYSDSMMIVHSSGSPSSTTSSSSTASPPFLSPDSVCSTNSGNSLKSFSQSSGRSSLRPSIPPSLTLPKFSSLSLLPSQTSPKESRGVNTFLQPSPNRKASPSLAERRGSLKGSLKLPGLADSNRGTPAFTLHPDDSNDIVFNLEGIRNGDLYPPSDCKGTSVDSDLPEKEIISLISCSKSDRHKSGGDTDSSGQPLACRWPSMEMITKLSRAYLDSESVIAIPLPSDAVGETGSRNLYIWIGKSFSLDNNCSLVDSNKAADTVENVDWVQIGESILCQMDLPKDTPIKIVRESEDQTELLALLSAL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
24PhosphorylationSKKMFWRSASWSASR
CCCCEEEECCCCCCC		19.7623776212
26PhosphorylationKMFWRSASWSASRTA
CCEEEECCCCCCCCH		23.8623776212
28PhosphorylationFWRSASWSASRTASQ
EEEECCCCCCCCHHC		17.5523776212
30PhosphorylationRSASWSASRTASQVP
EECCCCCCCCHHCCC		25.3423776212
64PhosphorylationRCPAAPLTPRSHHNS
CCCCCCCCCCCCCCC		18.6523111157
89PhosphorylationPLAISRRSLDEWPKA
CCEECCCCHHHCCCC		38.7830291188
109PhosphorylationGEWPHPPTPSGNKTG
CCCCCCCCCCCCCCC		34.2430291188
111PhosphorylationWPHPPTPSGNKTGER
CCCCCCCCCCCCCCE		58.4325561503
295PhosphorylationRVHAFPLSPTSLLRM
CCCCCCCCHHHHHHH		26.7730291188
297PhosphorylationHAFPLSPTSLLRMYK
CCCCCCHHHHHHHHH		28.7319880383
298PhosphorylationAFPLSPTSLLRMYKM
CCCCCHHHHHHHHHC		28.8819880383
341PhosphorylationAFIIQLPSAIYIWVG
EEEEECCCEEEEECC		35.5719880383
369PhosphorylationAVCQIARYEKVEAPI
HHHHHHCCCCCCCCE		15.8719880383
474PhosphorylationGFRYVSKTPLSRVYS
CCCEECCCCHHHHCC		23.1925561503
548PhosphorylationSLTLPKFSSLSLLPS
CCCCCCCCCCCCCCC		36.1723776212
549PhosphorylationLTLPKFSSLSLLPSQ
CCCCCCCCCCCCCCC		25.7223776212
551PhosphorylationLPKFSSLSLLPSQTS
CCCCCCCCCCCCCCC		29.7923776212
555PhosphorylationSSLSLLPSQTSPKES
CCCCCCCCCCCCCHH		46.1623776212
557PhosphorylationLSLLPSQTSPKESRG
CCCCCCCCCCCHHCC		51.8623776212
558PhosphorylationSLLPSQTSPKESRGV
CCCCCCCCCCHHCCC		26.7424601666
562PhosphorylationSQTSPKESRGVNTFL
CCCCCCHHCCCCCCC		40.2223172892
572PhosphorylationVNTFLQPSPNRKASP
CCCCCCCCCCCCCCH		23.1130291188
578PhosphorylationPSPNRKASPSLAERR
CCCCCCCCHHHHHHC		20.3223776212
591PhosphorylationRRGSLKGSLKLPGLA
HCCCCCCCEECCCCC		22.2725561503
604PhosphorylationLADSNRGTPAFTLHP
CCCCCCCCCCEEECC		14.2723776212
608PhosphorylationNRGTPAFTLHPDDSN
CCCCCCEEECCCCCC		26.6823776212
614PhosphorylationFTLHPDDSNDIVFNL
EEECCCCCCCEEEEC		43.7223776212
651PhosphorylationLPEKEIISLISCSKS
CCHHHEEEEEECCCC		25.8824894044
654PhosphorylationKEIISLISCSKSDRH
HHEEEEEECCCCCCC		20.0319880383
656PhosphorylationIISLISCSKSDRHKS
EEEEEECCCCCCCCC		28.5319880383
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MKP1_ARATH !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MKP1_ARATH !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MKP1_ARATH !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MKP1_ARATH !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MKP1_ARATH

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Arabidopsis MAP kinase phosphatase 1 is phosphorylated and activatedby its substrate AtMPK6.";
Park H.C., Song E.H., Nguyen X.C., Lee K., Kim K.E., Kim H.S.,Lee S.M., Kim S.H., Bae D.W., Yun D.J., Chung W.S.;
Plant Cell Rep. 30:1523-1531(2011).
Cited for: FUNCTION, INTERACTION WITH MPK6, AND PHOSPHORYLATION AT THR-64;THR-109; SER-558 AND SER-572.

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