MINT_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MINT_MOUSE
• UniProt AC: Q62504
• Protein Name: Msx2-interacting protein
• Gene Name: Spen
• Organism: Mus musculus (Mouse).
• Sequence Length: 3644
• Subcellular Localization: Nucleus . Associates with chromatin.
• Protein Description: May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways, such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA..
• Protein Sequence: MVRETRHLWVGNLPENVREEKIIEHFKRYGRVESVKILPKRGSEGGVAAFVDFVDIKSAQKAHNSVNKMGDRDLRTDYNEPGTIPSAARGLDETVSIASRSREVSGFRGSAGGPAYGPPPSLHAREGRYERRLDGASDNRERAYEHSAYGHHERGTGAFDRTRHYDQDYYRDPRERTLQHGLYYTSRSRSPNRFDAHDPRYEPRAREQFTLPSVVHRDIYRDDITREVRGRRPERSYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSSSSNTDSSDSSSTASDDSPARSVQSAAVPAPTSQLLSSLEKDEPRKSFGIKVQNLPVRSIDTSLKDGLFHEFKKFGKVTSVQIHGASEERYGLVFFRQQEDQEKALTASKGKLFFGMQIEVTAWVGPETESENEFRPLDERIDEFHPKATRTLFIGNLEKTTTYHDLRNIFQRFGEIVDIDIKKVNGVPQYAFLQYCDIASVCKAIKKMDGEYLGNNRLKLGFGKSMPTNCVWLDGLSSNVSDQYLTRHFCRYGPVVKVVFDRLKGMALVLYSEIEDAQAAVKETKGRKIGGNKIKVDFANRESQLAFYHCMEKSGQDMRDFYEMLTERRAGQMAQSKHEDWSADAQSPHKCREERRGSYEYSQERTYYENVRTPGTYPEDSRRDYPARGREFYSEWETYQGEYYDSRYYDEPREYREYRSDPYEQDIREYSYRQRERERERERFESDRDHERRPIERSQSPVHLRRPQSPGVSPAHSERLPSDSERRLYRRSSERSGSCSSVSPPRYDKLEKARLERYTKNEKADKERTFDPERVERERRIVRKEKGEKDKAERQKRKGKAHSPSSQPSETEQENDREQSPEKPRGSTKLSRDRADKEGPAKNRLELVPCVVLTRVKEKEGKVIEHPPPEKLKARLGRDTTKASALDQKPQAAQGEPAKSDPARGKALREKVLPSHAEVGEKEGRTKLRKHLKAEQTPELSALDLEKLEARKRRFADSGLKIEKQKPEIKKTSPETEDTRILLKKQPDTSRDGVLLREGESERKPVRKEILKRESKKTKLERLNSALSPKDCQDPAAVSAGSGSRPSSDVHAGLGELTHGSVETQETQPKKAIPSKPQPKQLQLLENQGPEKEEVRKNYCRPREEPAEHRAGQEKPHGGNAEEKLGIDIDHTQSYRKQMEQSRRKQRMEMEIAKAEKFGSPKKDVDDYERRSLVHEVGKPPQDVTDDSPPSKKRRTDHVDFDICTKRERNYRSSRQISEDSERTSCSPSVRHGSFHDDDDPRGSPRLVSVKGSPKGDEKGLPYPNAAVRDDPLKCNPYDSGKREQTADTAKIKLSVLNSEGEPSRWDPPMKQDPSRFDVSFPNSVIKRDSLRKRSVRDLEPGEVPSDSDEDAEHRSQSPRASSFYDSPRLSFLLRDRDQKLRERDERLASSLERNKFYSFALDKTITPDTKALLERAKSLSSSREENWSFLDWDSRFANFRNNKDKEKVDSAPRPIPSWYMKKKKIRTDSEGKLDDKKDERREEEQERQELFASRFLHSSIFEQDSKRLQHLERKSEESDFPPGRLYGRQASEGANSTSDSVQEPVVLFHSRFMELTRMQQKEKEKDQKPKEAEKQEEPETHPKTPEPAAETKEPEPKAPVSAGLPAVTITVVTPEPASSAPEKAEEAAEAPSPAGEKPAEPAPVSEETKLVSEPVSVPVEQPRQSDVPPGEDSRDSQDSAALAPSAPQESAATDAVPCVNAEPLTPGTTVSQVESSVDPKPSSPQPLSKLTQRSEEAEEGKVEKPDTTPSTEPDATQNAGVASEAQPPASEDVEANPPVAAKDRKTNKSKRSKTSVQAAAASVVEKPVTRKSERIDREKLKRSSSPRGEAQKLLELKMEAEKITRTASKSSGGDTEHPEPSLPLSRSRRRNVRSVYATMTDHESRSPAKEPVEQPRVTRKRLERELQEAVVPPTTPRRGRPPKTRRRAEEDGEHERKEPAETPRPAEGWRSPRSQKSAAAAGPQGKRGRNEQKVEAAAEAGAQASTREGNPKSRGEREAASEPKRDRRDPSTDKSGPDTFPVEVLERKPPEKTYKSKRGRARSTRSGMDRAAHQRSLEMAARAAGQAADKEAGPAAASPQESESPQKGSGSSPQLANNPADPDREAEEESASASTAPPEGTQLARQIELEQAVQNIAKLPEPSAAAASKGTATATATAASEEPAPEHGHKPAHQASETELAAAIGSIISDASGEPENFSAPPSVPPGSQTHPREGMEPGLHEAESGILETGTATESSAPQVSALDPPEGSADTKETRGNSGDSVQEAKGSKAEVTPPRKDKGRQKTTRRRKRNANKKVVAITETRASEAEQTQSESPAAEEATAATPEAPQEEKPSEKPPSPPAECTFDPSKTPPAESLSQENSAAEKTPCKAPVLPALPPLSQPALMDDGPQARFKVHSIIESDPVTPPSDSGIPPPTIPLVTIAKLPPPVIPGGVPHQSPPPKVTEWITRQEEPRAQSTPSPALPPDTKASDMDTSSSTLRKILMDPKYVSATGVTSTSVTTAIAEPVSAPCLQEAPAPPCDPKHPPLEGVSAAAVPNADTQASEVPVAADKEKVAPVIAPKITSVISRMPVSIDLENSQKITLAKPAPQTLTGLVSALTGLVNVSLVPVNALKGPVKGSVATLKGLVSTPAGPVNLLKGPVNVLTGPVNVLTTPVSATVGTVNAAPGPVTAACGVTATTGTAAVTGAVTAPAAKGKQRASSNENSRFHPGSMSVIDDRPADTGSGAGLRVNTSEGVVLLSYSGQKTEGPQRISAKISQIPPASAMDIEFQQSVSKSQVKADSITPTQSAPKGPQTPSAFANVAAHSTLVLTAQTYNASPVISSVKTDRPSLEKPEPIHLSVSTPVTQGGTVKVLTQGINTPPVLVHNQLVLTPSIVTTNKKLADPVTLKIETKVLQPANLGPTLTPHHPPALPSKLPAEVNHVPSGPSTPADRTIAHLATPKPDTHSPRPTGPTPGLFPRPCHPSSTTSTALSTNATVMLAAGIPVPQFISSIHPEQSVIMPPHSITQTVSLGHLSQGEVRMSTPTLPSITYSIRPETLHSPRAPLQPQQIEARAPQRVGTPQPATTGVPALATQHPPEEEVHYHLPVARAAAPVQSEVLVMQSEYRLHPYTVPRDVRIMVHPHVTAVSEQPRATEGVVKVPPANKAPQQLVKEAVKTSDAKAVPAPAPVPVPVPVPTPAPPPHGEARILTVTPSSQLQGLPLTPPVVVTHGVQIVHSSGELFQEYRYGDVRTYHAPAQQLTHTQFPVASSISLASRTKTSAQVPPEGEPLQSTQSAQPAPSTQATQPIPPAPPCQPSQLSQPAQPPSGKIPQVSQEAKGTQTGGVEQTRLPAIPTNRPSEPHAQLQRAPVETAQPAHPSPVSVSMKPDLPSPLSSQAAPKQPLFVPANSGPSTPPGLALPHAEVQPAPKQESSPHGTPQRPVDMVQLLKKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAHRSLPLSEGGPPLRIAQRMRLEASQLEGVARRMTVETDYCLLLALPCGRDQEDVVSQTESLKAAFITYLQAKQAAGIINVPNPGSNQPAYVLQIFPPCEFSESHLSRLAPDLLASISNISPHLMIVIASV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
43	Phosphorylation	KILPKRGSEGGVAAF EEECCCCCCCCEEEE	36.78	27600695
99	Phosphorylation	DETVSIASRSREVSG CCCCHHHHCCCCCCC	29.17	-
108	Methylation	SREVSGFRGSAGGPA CCCCCCCCCCCCCCC	41.50	-
116	Phosphorylation	GSAGGPAYGPPPSLH CCCCCCCCCCCCCHH	33.04	29514104
121	Phosphorylation	PAYGPPPSLHAREGR CCCCCCCCHHCCCCC	38.26	21454597
144	Phosphorylation	SDNRERAYEHSAYGH CCCHHHHHHHCCCCC	22.01	-
147	Phosphorylation	RERAYEHSAYGHHER HHHHHHHCCCCCCCC	15.96	-
149	Phosphorylation	RAYEHSAYGHHERGT HHHHHCCCCCCCCCC	21.73	-
188	Phosphorylation	GLYYTSRSRSPNRFD CCCCCCCCCCCCCCC	36.56	26239621
190	Phosphorylation	YYTSRSRSPNRFDAH CCCCCCCCCCCCCCC	27.98	26239621
236	Phosphorylation	RGRRPERSYQHSRSR CCCCCCCCCCCCCCC	27.73	27717184
240	Phosphorylation	PERSYQHSRSRSPHS CCCCCCCCCCCCCCC	19.20	27717184
242	Phosphorylation	RSYQHSRSRSPHSSQ CCCCCCCCCCCCCHH	39.87	27717184
244	Phosphorylation	YQHSRSRSPHSSQSR CCCCCCCCCCCHHCC	28.36	29109428
254	Phosphorylation	SSQSRNQSPQRLASQ CHHCCCCCHHHHHHH	26.92	23384938
288	Phosphorylation	SDSISSSSSSSNTDS CCCCCCCCCCCCCCC	35.87	-
289	Phosphorylation	DSISSSSSSSNTDSS CCCCCCCCCCCCCCC	39.47	-
295	Phosphorylation	SSSSNTDSSDSSSTA CCCCCCCCCCCCCCC	33.72	-
303	Phosphorylation	SDSSSTASDDSPARS CCCCCCCCCCCCCCH	41.88	-
310	Phosphorylation	SDDSPARSVQSAAVP CCCCCCCHHHHHCCC	26.98	21743459
313	Phosphorylation	SPARSVQSAAVPAPT CCCCHHHHHCCCCCH	18.95	28066266
325	Phosphorylation	APTSQLLSSLEKDEP CCHHHHHHHHCCCCC	41.28	27149854
326	Phosphorylation	PTSQLLSSLEKDEPR CHHHHHHHHCCCCCC	40.28	27149854
440	Phosphorylation	FHPKATRTLFIGNLE HCCCCCEEEEECCHH	22.97	17242355
449	Phosphorylation	FIGNLEKTTTYHDLR EECCHHHCCCHHHHH	18.26	17242355
450	Phosphorylation	IGNLEKTTTYHDLRN ECCHHHCCCHHHHHH	36.10	17242355
624 (in isoform 2)	Phosphorylation	-	47.90	26824392
631	Phosphorylation	QSKHEDWSADAQSPH HHCCCCCCCCCCCHH	28.70	28285833
636	Phosphorylation	DWSADAQSPHKCREE CCCCCCCCHHHCHHH	30.60	23684622
647	Phosphorylation	CREERRGSYEYSQER CHHHHCCCCCCCCCC	16.99	23527152
648	Phosphorylation	REERRGSYEYSQERT HHHHCCCCCCCCCCE	23.01	28833060
650	Phosphorylation	ERRGSYEYSQERTYY HHCCCCCCCCCCEEE	13.86	28833060
651	Phosphorylation	RRGSYEYSQERTYYE HCCCCCCCCCCEEEC	17.39	28833060
662	Phosphorylation	TYYENVRTPGTYPED EEECCCCCCCCCCCC	23.06	29514104
747	Phosphorylation	ERRPIERSQSPVHLR CCCCCCCCCCCCCCC	23.40	25521595
749	Phosphorylation	RPIERSQSPVHLRRP CCCCCCCCCCCCCCC	30.09	26824392
758	Phosphorylation	VHLRRPQSPGVSPAH CCCCCCCCCCCCHHH	26.72	25521595
762	Phosphorylation	RPQSPGVSPAHSERL CCCCCCCCHHHHCCC	23.45	25521595
766	Phosphorylation	PGVSPAHSERLPSDS CCCCHHHHCCCCCHH	26.90	25521595
771	Phosphorylation	AHSERLPSDSERRLY HHHCCCCCHHHHHHH	59.36	21082442
773	Phosphorylation	SERLPSDSERRLYRR HCCCCCHHHHHHHHH	37.02	25159016
785	Phosphorylation	YRRSSERSGSCSSVS HHHCCCCCCCCCCCC	30.89	25159016
786	Phosphorylation	RRSSERSGSCSSVSP HHCCCCCCCCCCCCC	38.60	24719451
787	Phosphorylation	RSSERSGSCSSVSPP HCCCCCCCCCCCCCC	16.45	25159016
788	Phosphorylation	SSERSGSCSSVSPPR CCCCCCCCCCCCCCC	3.92	24719451
789	Phosphorylation	SERSGSCSSVSPPRY CCCCCCCCCCCCCCH	35.16	25159016
790	Phosphorylation	ERSGSCSSVSPPRYD CCCCCCCCCCCCCHH	30.83	25159016
791	Phosphorylation	RSGSCSSVSPPRYDK CCCCCCCCCCCCHHH	5.98	24719451
792	Phosphorylation	SGSCSSVSPPRYDKL CCCCCCCCCCCHHHH	31.00	25159016
852	Phosphorylation	KRKGKAHSPSSQPSE HHCCCCCCCCCCCCH	31.19	21149613
854	Phosphorylation	KGKAHSPSSQPSETE CCCCCCCCCCCCHHH	44.62	21149613
855	Phosphorylation	GKAHSPSSQPSETEQ CCCCCCCCCCCHHHC	49.87	21149613
858	Phosphorylation	HSPSSQPSETEQEND CCCCCCCCHHHCCCC	49.90	21149613
860	Phosphorylation	PSSQPSETEQENDRE CCCCCCHHHCCCCCC	47.51	21149613
869	Phosphorylation	QENDREQSPEKPRGS CCCCCCCCCCCCCCC	30.21	26643407
1021	Phosphorylation	QKPEIKKTSPETEDT CCCCCCCCCCCCCCC	44.50	26745281
1022	Phosphorylation	KPEIKKTSPETEDTR CCCCCCCCCCCCCCE	29.62	25521595
1023	Phosphorylation	PEIKKTSPETEDTRI CCCCCCCCCCCCCEE	58.73	24719451
1025	Phosphorylation	IKKTSPETEDTRILL CCCCCCCCCCCEEEE	42.41	26745281
1067	Phosphorylation	LKRESKKTKLERLNS HHHHHHHHHHHHHHH	44.60	25266776
1074	Phosphorylation	TKLERLNSALSPKDC HHHHHHHHCCCCCCC	34.87	25521595
1077	Phosphorylation	ERLNSALSPKDCQDP HHHHHCCCCCCCCCC	29.62	26824392
1096	Phosphorylation	AGSGSRPSSDVHAGL CCCCCCCCCCCCCCC	37.75	-
1116	Phosphorylation	GSVETQETQPKKAIP CCCCCCCCCCCCCCC	40.11	-
1183	Phosphorylation	IDIDHTQSYRKQMEQ CCCCCHHHHHHHHHH	28.23	-
1209	Phosphorylation	AKAEKFGSPKKDVDD HHHHHHCCCCCCCCH	36.36	25159016
1210	Phosphorylation	KAEKFGSPKKDVDDY HHHHHCCCCCCCCHH	48.36	24719451
1221	Phosphorylation	VDDYERRSLVHEVGK CCHHHHHHHHHHCCC	40.75	25619855
1234	Phosphorylation	GKPPQDVTDDSPPSK CCCCCCCCCCCCCCC	42.24	25619855
1237	Phosphorylation	PQDVTDDSPPSKKRR CCCCCCCCCCCCCCC	41.33	27087446
1240	Phosphorylation	VTDDSPPSKKRRTDH CCCCCCCCCCCCCCC	54.94	25619855
1267	Phosphorylation	YRSSRQISEDSERTS HHCCCCCCCCCCCCC	27.32	25521595
1270	Phosphorylation	SRQISEDSERTSCSP CCCCCCCCCCCCCCC	25.56	25266776
1273	Phosphorylation	ISEDSERTSCSPSVR CCCCCCCCCCCCCCC	29.99	24759943
1274	Phosphorylation	SEDSERTSCSPSVRH CCCCCCCCCCCCCCC	20.86	24759943
1276	Phosphorylation	DSERTSCSPSVRHGS CCCCCCCCCCCCCCC	21.70	19060867
1283	Phosphorylation	SPSVRHGSFHDDDDP CCCCCCCCCCCCCCC	17.18	25521595
1293	Phosphorylation	DDDDPRGSPRLVSVK CCCCCCCCCCEEEEE	14.23	25521595
1298	Phosphorylation	RGSPRLVSVKGSPKG CCCCCEEEEECCCCC	23.78	25159016
1300	Acetylation	SPRLVSVKGSPKGDE CCCEEEEECCCCCCC	46.28	6567135
1302	Phosphorylation	RLVSVKGSPKGDEKG CEEEEECCCCCCCCC	20.09	26824392
1303	Phosphorylation	LVSVKGSPKGDEKGL EEEEECCCCCCCCCC	54.00	24719451
1304	Acetylation	VSVKGSPKGDEKGLP EEEECCCCCCCCCCC	79.34	6566617
1348	Phosphorylation	IKLSVLNSEGEPSRW EEEEEECCCCCCCCC	42.70	28066266
1353	Phosphorylation	LNSEGEPSRWDPPMK ECCCCCCCCCCCCCC	41.52	28066266
1373	Phosphorylation	FDVSFPNSVIKRDSL CCCCCCCCCCCHHHH	26.00	28576409
1395	Phosphorylation	LEPGEVPSDSDEDAE CCCCCCCCCCHHCHH	55.72	25521595
1397	Phosphorylation	PGEVPSDSDEDAEHR CCCCCCCCHHCHHHH	47.43	25521595
1405	Phosphorylation	DEDAEHRSQSPRASS HHCHHHHHCCCCHHH	36.60	26643407
1406	Phosphorylation	EDAEHRSQSPRASSF HCHHHHHCCCCHHHH	58.36	24719451
1407	Phosphorylation	DAEHRSQSPRASSFY CHHHHHCCCCHHHHC	20.01	26643407
1416	Phosphorylation	RASSFYDSPRLSFLL CHHHHCCCHHHHHHH	10.67	21183079
1420	Phosphorylation	FYDSPRLSFLLRDRD HCCCHHHHHHHCHHH	18.35	19060867
1439	Phosphorylation	ERDERLASSLERNKF HHHHHHHHHHHHCCH	39.79	28066266
1440	Phosphorylation	RDERLASSLERNKFY HHHHHHHHHHHCCHH	28.74	28066266
1448	Phosphorylation	LERNKFYSFALDKTI HHHCCHHHHHCCCCC	13.74	19060867
1454	Phosphorylation	YSFALDKTITPDTKA HHHHCCCCCCHHHHH	29.74	-
1456	Phosphorylation	FALDKTITPDTKALL HHCCCCCCHHHHHHH	21.97	-
1568	Phosphorylation	LERKSEESDFPPGRL HHHHHCCCCCCCCCC	40.26	22802335
1581	Phosphorylation	RLYGRQASEGANSTS CCCCCCCCCCCCCCC	28.38	22942356
1582	Phosphorylation	LYGRQASEGANSTSD CCCCCCCCCCCCCCC	66.40	24719451
1586	Phosphorylation	QASEGANSTSDSVQE CCCCCCCCCCCCCCC	28.84	23984901
1587	Phosphorylation	ASEGANSTSDSVQEP CCCCCCCCCCCCCCC	36.04	28833060
1588	Phosphorylation	SEGANSTSDSVQEPV CCCCCCCCCCCCCCH	27.92	28833060
1590	Phosphorylation	GANSTSDSVQEPVVL CCCCCCCCCCCCHHH	26.01	28833060
1630	Phosphorylation	EKQEEPETHPKTPEP HHHCCCCCCCCCCCC	54.94	25159016
1634	Phosphorylation	EPETHPKTPEPAAET CCCCCCCCCCCCCCC	37.02	25521595
1641	Phosphorylation	TPEPAAETKEPEPKA CCCCCCCCCCCCCCC	35.66	25159016
1682	Phosphorylation	EEAAEAPSPAGEKPA HHHHHCCCCCCCCCC	34.14	26824392
1695	Phosphorylation	PAEPAPVSEETKLVS CCCCCCCCCCCCCCC	28.76	23984901
1698	Phosphorylation	PAPVSEETKLVSEPV CCCCCCCCCCCCCCC	26.15	23984901
1772	Phosphorylation	SSVDPKPSSPQPLSK ECCCCCCCCCCCHHH	61.86	25195567
1773	Phosphorylation	SVDPKPSSPQPLSKL CCCCCCCCCCCHHHH	35.76	29233185
1839	Phosphorylation	KDRKTNKSKRSKTSV HCCCCCCHHHCHHHH	35.06	-
1842	Phosphorylation	KTNKSKRSKTSVQAA CCCCHHHCHHHHHHH	43.98	-
1844	Phosphorylation	NKSKRSKTSVQAAAA CCHHHCHHHHHHHHH	35.06	-
1873	Phosphorylation	DREKLKRSSSPRGEA CHHHHHCCCCCCHHH	33.31	29899451
1874	Phosphorylation	REKLKRSSSPRGEAQ HHHHHCCCCCCHHHH	48.68	29899451
1875	Phosphorylation	EKLKRSSSPRGEAQK HHHHCCCCCCHHHHH	21.62	25266776
1915	Phosphorylation	PEPSLPLSRSRRRNV CCCCCCCCHHHHHCC	26.69	-
1924	Phosphorylation	SRRRNVRSVYATMTD HHHHCCHHHEEECCC	18.39	25777480
1926	Phosphorylation	RRNVRSVYATMTDHE HHCCHHHEEECCCCC	9.52	25777480
1928	Phosphorylation	NVRSVYATMTDHESR CCHHHEEECCCCCCC	11.69	25266776
1930	Phosphorylation	RSVYATMTDHESRSP HHHEEECCCCCCCCC	29.83	26643407
1934	Phosphorylation	ATMTDHESRSPAKEP EECCCCCCCCCCCCC	34.34	26643407
1935	Dimethylation	TMTDHESRSPAKEPV ECCCCCCCCCCCCCC	43.61	-
1935	Methylation	TMTDHESRSPAKEPV ECCCCCCCCCCCCCC	43.61	58856423
1936	Phosphorylation	MTDHESRSPAKEPVE CCCCCCCCCCCCCCC	38.19	21082442
1964	Phosphorylation	QEAVVPPTTPRRGRP HHCCCCCCCCCCCCC	43.28	26643407
1965	Phosphorylation	EAVVPPTTPRRGRPP HCCCCCCCCCCCCCC	22.14	25266776
1992	Phosphorylation	ERKEPAETPRPAEGW CCCCCCCCCCCCCCC	31.49	26643407
2001	Phosphorylation	RPAEGWRSPRSQKSA CCCCCCCCCHHHHHH	20.39	28066266
2051	Phosphorylation	RGEREAASEPKRDRR HHHHHHCCCCCCCCC	62.57	25266776
2061	Phosphorylation	KRDRRDPSTDKSGPD CCCCCCCCCCCCCCC	54.23	25777480
2062	Phosphorylation	RDRRDPSTDKSGPDT CCCCCCCCCCCCCCC	53.48	25777480
2065	Phosphorylation	RDPSTDKSGPDTFPV CCCCCCCCCCCCCCH	59.37	25777480
2069	Phosphorylation	TDKSGPDTFPVEVLE CCCCCCCCCCHHHHC	32.73	25777480
2078	Acetylation	PVEVLERKPPEKTYK CHHHHCCCCCCCCCC	56.39	8276483
2106	Phosphorylation	DRAAHQRSLEMAARA HHHHHHHHHHHHHHH	23.31	25521595
2128	Phosphorylation	EAGPAAASPQESESP HCCCCCCCCCCCCCC	23.53	25521595
2132	Phosphorylation	AAASPQESESPQKGS CCCCCCCCCCCCCCC	37.82	25619855
2134	Phosphorylation	ASPQESESPQKGSGS CCCCCCCCCCCCCCC	41.74	27087446
2139	Phosphorylation	SESPQKGSGSSPQLA CCCCCCCCCCCCHHH	42.40	26643407
2141	Phosphorylation	SPQKGSGSSPQLANN CCCCCCCCCCHHHCC	40.31	26643407
2142	Phosphorylation	PQKGSGSSPQLANNP CCCCCCCCCHHHCCC	21.86	26643407
2171	Phosphorylation	STAPPEGTQLARQIE CCCCCCHHHHHHHHH	20.81	-
2325	Phosphorylation	KGSKAEVTPPRKDKG CCCCCCCCCCCCCCC	21.05	24899341
2362	Phosphorylation	RASEAEQTQSESPAA CHHHHHHHHCCCHHH	26.10	30635358
2364	Phosphorylation	SEAEQTQSESPAAEE HHHHHHHCCCHHHHH	43.35	21149613
2366	Phosphorylation	AEQTQSESPAAEEAT HHHHHCCCHHHHHHH	25.70	21149613
2373	Phosphorylation	SPAAEEATAATPEAP CHHHHHHHCCCCCCC	21.80	21149613
2376	Phosphorylation	AEEATAATPEAPQEE HHHHHCCCCCCCCCC	21.14	30352176
2401	Phosphorylation	AECTFDPSKTPPAES CCCCCCCCCCCCHHH	51.51	29514104
2403	Phosphorylation	CTFDPSKTPPAESLS CCCCCCCCCCHHHCC	38.55	30352176
2419	Phosphorylation	ENSAAEKTPCKAPVL CCCHHHCCCCCCCCC	25.98	-
2450	Phosphorylation	QARFKVHSIIESDPV CCEEEEEEEEECCCC	28.40	26745281
2454	Phosphorylation	KVHSIIESDPVTPPS EEEEEEECCCCCCCC	36.48	26745281
2458	Phosphorylation	IIESDPVTPPSDSGI EEECCCCCCCCCCCC	34.57	26239621
2461	Phosphorylation	SDPVTPPSDSGIPPP CCCCCCCCCCCCCCC	45.68	26745281
2463	Phosphorylation	PVTPPSDSGIPPPTI CCCCCCCCCCCCCCC	42.85	26745281
2469	Phosphorylation	DSGIPPPTIPLVTIA CCCCCCCCCCEEEEE	40.79	23984901
2474	Phosphorylation	PPTIPLVTIAKLPPP CCCCCEEEEECCCCC	23.93	23984901
2490	Phosphorylation	IPGGVPHQSPPPKVT CCCCCCCCCCCCCCC	52.11	24719451
2491	Phosphorylation	PGGVPHQSPPPKVTE CCCCCCCCCCCCCCH	36.02	26824392
2497	Phosphorylation	QSPPPKVTEWITRQE CCCCCCCCHHHHCCC	31.56	26643407
2501	Phosphorylation	PKVTEWITRQEEPRA CCCCHHHHCCCCCCC	27.63	26643407
2837	Phosphorylation	QVKADSITPTQSAPK HCCCCCCCCCCCCCC	25.00	30635358
2883	Phosphorylation	SVKTDRPSLEKPEPI ECCCCCCCCCCCCCC	50.48	27149854
2896	O-linked_Glycosylation	PIHLSVSTPVTQGGT CCEEEEECCCCCCCE	21.44	22517741
2899	O-linked_Glycosylation	LSVSTPVTQGGTVKV EEEECCCCCCCEEEE	23.77	22517741
2913	Phosphorylation	VLTQGINTPPVLVHN EECCCCCCCCEEEEC	27.35	30352176
2925	Phosphorylation	VHNQLVLTPSIVTTN EECEEEECCCCEECC	13.91	-
2982	Phosphorylation	HVPSGPSTPADRTIA CCCCCCCCCCCCCEE	26.15	25338131
3088	Asymmetric dimethylarginine	PSITYSIRPETLHSP CEEEEECCHHHCCCC	19.64	-
3088	Methylation	PSITYSIRPETLHSP CEEEEECCHHHCCCC	19.64	-
3096	Asymmetric dimethylarginine	PETLHSPRAPLQPQQ HHHCCCCCCCCCHHH	52.42	-
3096	Methylation	PETLHSPRAPLQPQQ HHHCCCCCCCCCHHH	52.42	-
3114	Phosphorylation	RAPQRVGTPQPATTG CCCCCCCCCCCCCCC	18.85	26824392
3119	Phosphorylation	VGTPQPATTGVPALA CCCCCCCCCCCCCCC	30.66	26643407
3120	Phosphorylation	GTPQPATTGVPALAT CCCCCCCCCCCCCCC	37.98	26643407
3257	Phosphorylation	QLQGLPLTPPVVVTH HCCCCCCCCCEEEEC	24.49	-
3376	Phosphorylation	QEAKGTQTGGVEQTR CCCCCCCCCCCCCCC	35.42	19655815
3382	Phosphorylation	QTGGVEQTRLPAIPT CCCCCCCCCCCCCCC	22.22	19655815
3406	Phosphorylation	LQRAPVETAQPAHPS CCCCCCCCCCCCCCC	30.72	26643407
3413	Phosphorylation	TAQPAHPSPVSVSMK CCCCCCCCCCCCCCC	28.24	26643407
3416	Phosphorylation	PAHPSPVSVSMKPDL CCCCCCCCCCCCCCC	16.32	26643407
3418	Phosphorylation	HPSPVSVSMKPDLPS CCCCCCCCCCCCCCC	17.37	26643407
3425	Phosphorylation	SMKPDLPSPLSSQAA CCCCCCCCCCCCCCC	45.85	26643407
3428	Phosphorylation	PDLPSPLSSQAAPKQ CCCCCCCCCCCCCCC	24.64	26643407
3429	Phosphorylation	DLPSPLSSQAAPKQP CCCCCCCCCCCCCCC	31.36	26643407
3443	Phosphorylation	PLFVPANSGPSTPPG CEEECCCCCCCCCCC	54.94	26643407
3446	Phosphorylation	VPANSGPSTPPGLAL ECCCCCCCCCCCCCC	58.01	26643407
3447	Phosphorylation	PANSGPSTPPGLALP CCCCCCCCCCCCCCC	36.31	24453211
3466	Phosphorylation	QPAPKQESSPHGTPQ CCCCCCCCCCCCCCC	46.83	26060331
3467	Phosphorylation	PAPKQESSPHGTPQR CCCCCCCCCCCCCCC	21.84	26060331
3499	Phosphorylation	LLALKNDTAAVQLHF HHHCCCCCEEEEEEE	26.38	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MINT_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MINT_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MINT_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MINT_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-758; SER-762 ANDSER-766, AND MASS SPECTROMETRY.
PubMed: 17242355