MILK2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MILK2_MOUSE
• UniProt AC: Q3TN34
• Protein Name: MICAL-like protein 2
• Gene Name: Micall2
• Organism: Mus musculus (Mouse).
• Sequence Length: 1009
• Subcellular Localization: Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Recycling endosome. Cell projection. Cytoplasm, cytoskeleton. Cytoplasm, cytosol.
• Protein Description: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth..
• Protein Sequence: MAAIKALQEWCRQQCEGYRDVSITNMTTSFRDGLAFCAILHRHRPDLINFSALRKENIYENNKLAFQVAEEQLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGIKRPSSDSTEELSGKKGLSQPAKLPSPAQTQRSPLSPARTNPVVQRNEGGSQRPSPKAAPGTAGSSVSSICGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSSTLHSGAYRATGEPGVFVCTHHSSEVTSVSPKSSNLASRKPGGVTADTRPFGVSWTVQEANGEGTPLRVRTAAWEHAGGNTTAKGFVQTELKPPSTSQVHVGSSAGPKLPTITVTTTSVTSKALTHVTNSSPIGWSSPAQSSPANFNSRPVVSPSARNTHLPGSQGQTASKGVKTQLNLNSESSNTAVTPAWTSSASKTQQAREKFFQTPPSAPAPASAPAPAPTSKVPTVVTVPTSKVPNVVTAPTSKVPTVVTVPTSKVPTVVSAPTSKVPTVVSAPTSKVPTVVNSTNSRVTTVVNAPTSKVPTVVSATNGRVPTVVTAHTGRVPAVMNTSASKVSPVVDAPAQESSREQALSVLRKALPALTGSGTQAPNRSFPATSSVLVTLPKNEVPQKVPSDKLSALTTQTPNFTIKLEPSAPVNVGNTAVFLQAGKKSPSISPRVGKTSVGSRPQAEVAGVKGPGPISQEGQEEGPEGWRARLKPVDKKTPAGRSLEQKEPVLAEPRIGDTSRKASSSSDSSVHITLTSIQHKRKPCPAGSGPSPAALSPSPSHRKKLAVPPSLDVSADWLQPEPKKQEDGTRSCKEEKSPTRWSRERSAVLDSGLAPPGEAVTSPVRLHPDYIPQEELQRQLQDIESQLDALELRGVELEKRLRAAEGDASEDSLMVDWFRLIHEKQLLLRLESELMYKSKDQRLEEQQLDLQGELRRLMDKPEGLKSPQDRQREQELLSQYVNTVNDRSDIVDFLDEDRLREQEEDQMLENMIQNLGLQRKKSKSFLSKIWSSKSKSGQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
59	Phosphorylation	ALRKENIYENNKLAF HHCHHCCHHCCCCHH		29514104
105	Phosphorylation	YVSQYYNYFHGRSPI HHHHHHHHHCCCCCC		-
110	Phosphorylation	YNYFHGRSPIGGMAG HHHHCCCCCCCCCCC		28066266
122	Phosphorylation	MAGIKRPSSDSTEEL CCCCCCCCCCCHHHH		29514104
123	Phosphorylation	AGIKRPSSDSTEELS CCCCCCCCCCHHHHC		28973931
125	Phosphorylation	IKRPSSDSTEELSGK CCCCCCCCHHHHCCC		29550500
126	Phosphorylation	KRPSSDSTEELSGKK CCCCCCCHHHHCCCC		29550500
130	Phosphorylation	SDSTEELSGKKGLSQ CCCHHHHCCCCCCCC		30635358
136	Phosphorylation	LSGKKGLSQPAKLPS HCCCCCCCCCCCCCC		19854140
143	Phosphorylation	SQPAKLPSPAQTQRS CCCCCCCCHHHCCCC		26824392
147	Phosphorylation	KLPSPAQTQRSPLSP CCCCHHHCCCCCCCC		28507225
150	Phosphorylation	SPAQTQRSPLSPART CHHHCCCCCCCCCCC		26824392
153	Phosphorylation	QTQRSPLSPARTNPV HCCCCCCCCCCCCCC		21454597
168	Phosphorylation	VQRNEGGSQRPSPKA CCCCCCCCCCCCCCC		29514104
172	Phosphorylation	EGGSQRPSPKAAPGT CCCCCCCCCCCCCCC		26824392
208	Phosphorylation	HLADGRLYHRSCFRC HCCCCCEECCCCCCC		29514104
219	Phosphorylation	CFRCKQCSSTLHSGA CCCCCCCCCCCCCCC		30635358
220	Phosphorylation	FRCKQCSSTLHSGAY CCCCCCCCCCCCCCC		30635358
221	Phosphorylation	RCKQCSSTLHSGAYR CCCCCCCCCCCCCCC		30635358
224	Phosphorylation	QCSSTLHSGAYRATG CCCCCCCCCCCCCCC		30635358
230	Phosphorylation	HSGAYRATGEPGVFV CCCCCCCCCCCCEEE		25777480
239	Phosphorylation	EPGVFVCTHHSSEVT CCCEEEEECCCCCCE		25293948
242	Phosphorylation	VFVCTHHSSEVTSVS EEEEECCCCCCEEEC		28066266
243	Phosphorylation	FVCTHHSSEVTSVSP EEEECCCCCCEEECC		28066266
246	Phosphorylation	THHSSEVTSVSPKSS ECCCCCCEEECCCCC		28066266
247	Phosphorylation	HHSSEVTSVSPKSSN CCCCCCEEECCCCCC		28066266
249	Phosphorylation	SSEVTSVSPKSSNLA CCCCEEECCCCCCCC		25263469
314	O-linked_Glycosylation	QTELKPPSTSQVHVG EEEECCCCCCEEEEC		21540332
323	O-linked_Glycosylation	SQVHVGSSAGPKLPT CEEEECCCCCCCCCE		21540332
349	Phosphorylation	ALTHVTNSSPIGWSS HHHCCCCCCCCCCCC		30482847
350	Phosphorylation	LTHVTNSSPIGWSSP HHCCCCCCCCCCCCC		25338131
356	Phosphorylation	SSPIGWSSPAQSSPA CCCCCCCCCCCCCCC		26370283
360	Phosphorylation	GWSSPAQSSPANFNS CCCCCCCCCCCCCCC		26370283
372	Phosphorylation	FNSRPVVSPSARNTH CCCCCCCCCCCCCCC		28066266
374	Phosphorylation	SRPVVSPSARNTHLP CCCCCCCCCCCCCCC		28066266
383	Phosphorylation	RNTHLPGSQGQTASK CCCCCCCCCCCCCCC		25338131
412	Phosphorylation	TAVTPAWTSSASKTQ CCCCCCCCCCCHHHH		-
413	Phosphorylation	AVTPAWTSSASKTQQ CCCCCCCCCCHHHHH		-
414	Phosphorylation	VTPAWTSSASKTQQA CCCCCCCCCHHHHHH		-
416	Phosphorylation	PAWTSSASKTQQARE CCCCCCCHHHHHHHH		-
428	Phosphorylation	AREKFFQTPPSAPAP HHHHHHCCCCCCCCC		25777480
431	Phosphorylation	KFFQTPPSAPAPASA HHHCCCCCCCCCCCC		25777480
437	Phosphorylation	PSAPAPASAPAPAPT CCCCCCCCCCCCCCC		25777480
444	Phosphorylation	SAPAPAPTSKVPTVV CCCCCCCCCCCCEEE		25777480
445	Phosphorylation	APAPAPTSKVPTVVT CCCCCCCCCCCEEEE		25777480
456	O-linked_Glycosylation	TVVTVPTSKVPNVVT EEEEECCCCCCCEEE		21540332
511	Phosphorylation	TVVNSTNSRVTTVVN EEECCCCCCEEEEEE		20047950
514	Phosphorylation	NSTNSRVTTVVNAPT CCCCCCEEEEEECCC		-
522	O-linked_Glycosylation	TVVNAPTSKVPTVVS EEEECCCCCCCEEEE		55412687
552	Phosphorylation	RVPAVMNTSASKVSP CCCEEEECCCCCCCC		25338131
555	Phosphorylation	AVMNTSASKVSPVVD EEEECCCCCCCCCCC		25338131
558	Phosphorylation	NTSASKVSPVVDAPA ECCCCCCCCCCCCCC		26824392
575	Phosphorylation	SSREQALSVLRKALP CHHHHHHHHHHHHHH		29514104
637	Phosphorylation	FTIKLEPSAPVNVGN EEEEECCCCCCEECC		20531401
645	Phosphorylation	APVNVGNTAVFLQAG CCCEECCEEEEEECC		26824392
655	Phosphorylation	FLQAGKKSPSISPRV EEECCCCCCCCCCCC		26824392
657	Phosphorylation	QAGKKSPSISPRVGK ECCCCCCCCCCCCCC		26745281
659	Phosphorylation	GKKSPSISPRVGKTS CCCCCCCCCCCCCCC		25263469
665	Phosphorylation	ISPRVGKTSVGSRPQ CCCCCCCCCCCCCCC		25338131
666	Phosphorylation	SPRVGKTSVGSRPQA CCCCCCCCCCCCCCE		29514104
707	Phosphorylation	LKPVDKKTPAGRSLE CCCCCCCCCCCCCCC		22942356
712	Phosphorylation	KKTPAGRSLEQKEPV CCCCCCCCCCCCCCC		28973931
733	Phosphorylation	GDTSRKASSSSDSSV CCCCCCCCCCCCCCE		28973931
734	Phosphorylation	DTSRKASSSSDSSVH CCCCCCCCCCCCCEE		25168779
735	Phosphorylation	TSRKASSSSDSSVHI CCCCCCCCCCCCEEE		25168779
736	Phosphorylation	SRKASSSSDSSVHIT CCCCCCCCCCCEEEE		25168779
738	Phosphorylation	KASSSSDSSVHITLT CCCCCCCCCEEEEEE		25168779
739	Phosphorylation	ASSSSDSSVHITLTS CCCCCCCCEEEEEEE		25168779
743	Phosphorylation	SDSSVHITLTSIQHK CCCCEEEEEEEEECC		23567750
745	Phosphorylation	SSVHITLTSIQHKRK CCEEEEEEEEECCCC		23567750
758	Phosphorylation	RKPCPAGSGPSPAAL CCCCCCCCCCCCCCC		25777480
761	Phosphorylation	CPAGSGPSPAALSPS CCCCCCCCCCCCCCC		22817900
766	Phosphorylation	GPSPAALSPSPSHRK CCCCCCCCCCHHHHH		26824392
768	Phosphorylation	SPAALSPSPSHRKKL CCCCCCCCHHHHHCC		26824392
770	Phosphorylation	AALSPSPSHRKKLAV CCCCCCHHHHHCCCC		29472430
807	Phosphorylation	RSCKEEKSPTRWSRE CCCCCCCCCCHHHHH		29514104
816	Phosphorylation	TRWSRERSAVLDSGL CHHHHHHHHHHCCCC		24068923
821	Phosphorylation	ERSAVLDSGLAPPGE HHHHHHCCCCCCCCC		24068923
831	Phosphorylation	APPGEAVTSPVRLHP CCCCCCCCCCCCCCC		24068923
832	Phosphorylation	PPGEAVTSPVRLHPD CCCCCCCCCCCCCCC		27087446
840	Phosphorylation	PVRLHPDYIPQEELQ CCCCCCCCCCHHHHH		27717184
936	Phosphorylation	DKPEGLKSPQDRQRE HCCCCCCCHHHHHHH		26824392
950	Phosphorylation	EQELLSQYVNTVNDR HHHHHHHHHHHCCCH		29514104
994	Phosphorylation	LQRKKSKSFLSKIWS CCHHHCHHHHHHHHC		29176673

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MILK2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MILK2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MILK2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MILK2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.