MILK1_MOUSE - dbPTM
MILK1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MILK1_MOUSE
UniProt AC Q8BGT6
Protein Name MICAL-like protein 1
Gene Name Micall1
Organism Mus musculus (Mouse).
Sequence Length 870
Subcellular Localization Recycling endosome membrane
Peripheral membrane protein. Late endosome membrane. Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6 (By similarity)..
Protein Description Probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, may act as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. May be involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. May indirectly play a role in neurite outgrowth..
Protein Sequence MAGPRGALLAWCRRQCEGYRGVDIRDLSSSFRDGLAFCAILHRHRPDLLDFQSLSKENVFENNRLAFEVAEKELGIPALLDPNDMVSMSVPDCLSIMTYVSQYYNHFTSSGQAAASPPKPGKDPAPPSPTSTSPAVQPGEEAQGDDLSPDSLSEQGKQQPPSSACAACGQRVHLVQRYLAEGRLYHRHCFRCRQCSSTLVPGSYSSGPEEGTFVCAERCTRLGPGSRSGTRLLSQQRQQPAAAEAKDAEDNDPSLSVAAVAEADRLQASSEVQFHTPTKPPLPSKPQELASPPGGRPTPAPRKASESSALTPPTPRPRSSLQQDGTVEQSVSSGLVNGRLQEPPVPKPRGTPKLSERMAAPRKDPPWITLVQTEPKKKPAPQPPSSGPGPLSQAYRQVEDGGLEEQTQKSSGTEPEPKPYNPFEEEEEEEGEPAPPVPSPSLAPPVPSPSPAPPVPSPAPAPSEATPKSLHPWYGITPTSSPKTKKRPAPRAPSASPLAIHASRLSHSEPPSATPSPALSVESLSSESSSHTANAEPLEPPAVPKSSSDPAVHVPGTPGTSGNSVTPSANSSLSSSGELGQPSGEQMLQARTKGSAGTHSTKPFSGATPTPFLLAGDRNPAPPVGSASPQLQIKSSCKENPFNRKPSPSASPTVRKATKGAKPVRPPAPGHGFPLIKRKVQADQYIPEEDIYGEMDNIERQLDALEHSGVLLEEKLRGGANEGSEDDMLVDWFKLIHEKHLLVRRESELIYVFKQQNLEQRQADVEFELRCLLNKPEKDWTDEDRAREKVLMQELMTLIEQRDAIVNCLDEDRQREEEEDKMLETMIKKKDFQREAESDSKKKGKFKTIKVLKFLGNKREAKSKAPGDKS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
87PhosphorylationLDPNDMVSMSVPDCL
CCCCCCCCCCHHHHH		9.94-
89PhosphorylationPNDMVSMSVPDCLSI
CCCCCCCCHHHHHHH		24.00-
128PhosphorylationGKDPAPPSPTSTSPA
CCCCCCCCCCCCCCC		39.4925521595
130PhosphorylationDPAPPSPTSTSPAVQ
CCCCCCCCCCCCCCC		49.3129472430
131PhosphorylationPAPPSPTSTSPAVQP
CCCCCCCCCCCCCCC		30.2125293948
132PhosphorylationAPPSPTSTSPAVQPG
CCCCCCCCCCCCCCC		41.0025521595
133PhosphorylationPPSPTSTSPAVQPGE
CCCCCCCCCCCCCCC		15.6125521595
148PhosphorylationEAQGDDLSPDSLSEQ
CCCCCCCCHHHHHHH		33.3925521595
256PhosphorylationEDNDPSLSVAAVAEA
CCCCCCHHHHHHHHH		17.6625338131
269PhosphorylationEADRLQASSEVQFHT
HHHHCCCCCCEEECC		17.6725338131
270PhosphorylationADRLQASSEVQFHTP
HHHCCCCCCEEECCC		44.8125338131
291PhosphorylationSKPQELASPPGGRPT
CCCHHHCCCCCCCCC		44.23-
305PhosphorylationTPAPRKASESSALTP
CCCCCCCCCCCCCCC		40.8326824392
307PhosphorylationAPRKASESSALTPPT
CCCCCCCCCCCCCCC		20.5825266776
308PhosphorylationPRKASESSALTPPTP
CCCCCCCCCCCCCCC		24.2027742792
311PhosphorylationASESSALTPPTPRPR
CCCCCCCCCCCCCCC		27.2626824392
314PhosphorylationSSALTPPTPRPRSSL
CCCCCCCCCCCCCCC		32.8827742792
319PhosphorylationPPTPRPRSSLQQDGT
CCCCCCCCCCCCCCC		37.7825619855
320PhosphorylationPTPRPRSSLQQDGTV
CCCCCCCCCCCCCCE		31.3225619855
326PhosphorylationSSLQQDGTVEQSVSS
CCCCCCCCEEEHHHC		29.2025619855
347AcetylationLQEPPVPKPRGTPKL
CCCCCCCCCCCCCCH		47.8019851025
351PhosphorylationPVPKPRGTPKLSERM
CCCCCCCCCCHHHHH		20.6626824392
469PhosphorylationPSEATPKSLHPWYGI
CCCCCCCCCCCCCCC		32.8727087446
474PhosphorylationPKSLHPWYGITPTSS
CCCCCCCCCCCCCCC		11.7826239621
477PhosphorylationLHPWYGITPTSSPKT
CCCCCCCCCCCCCCC		19.0227087446
479PhosphorylationPWYGITPTSSPKTKK
CCCCCCCCCCCCCCC		32.9427742792
480PhosphorylationWYGITPTSSPKTKKR
CCCCCCCCCCCCCCC		45.9327087446
481PhosphorylationYGITPTSSPKTKKRP
CCCCCCCCCCCCCCC		32.6627087446
494PhosphorylationRPAPRAPSASPLAIH
CCCCCCCCCCCCEEE		40.1527087446
496PhosphorylationAPRAPSASPLAIHAS
CCCCCCCCCCEEEHH		25.4527087446
503PhosphorylationSPLAIHASRLSHSEP
CCCEEEHHHCCCCCC		21.4225619855
508PhosphorylationHASRLSHSEPPSATP
EHHHCCCCCCCCCCC		48.7125293948
512PhosphorylationLSHSEPPSATPSPAL
CCCCCCCCCCCCCCC		56.3325293948
514PhosphorylationHSEPPSATPSPALSV
CCCCCCCCCCCCCCH		28.7425293948
516PhosphorylationEPPSATPSPALSVES
CCCCCCCCCCCCHHH		20.6025293948
520PhosphorylationATPSPALSVESLSSE
CCCCCCCCHHHCCCC		26.4125293948
523PhosphorylationSPALSVESLSSESSS
CCCCCHHHCCCCCCC		31.2525293948
525PhosphorylationALSVESLSSESSSHT
CCCHHHCCCCCCCCC		41.1425293948
526PhosphorylationLSVESLSSESSSHTA
CCHHHCCCCCCCCCC		46.9525293948
528PhosphorylationVESLSSESSSHTANA
HHHCCCCCCCCCCCC		38.8025293948
529PhosphorylationESLSSESSSHTANAE
HHCCCCCCCCCCCCC		23.3025293948
530PhosphorylationSLSSESSSHTANAEP
HCCCCCCCCCCCCCC		33.8525293948
532PhosphorylationSSESSSHTANAEPLE
CCCCCCCCCCCCCCC		24.4525293948
610PhosphorylationPFSGATPTPFLLAGD
CCCCCCCCCEEECCC		23.4828059163
626PhosphorylationNPAPPVGSASPQLQI
CCCCCCCCCCCCEEE		26.3026824392
628PhosphorylationAPPVGSASPQLQIKS
CCCCCCCCCCEEEHH		18.1827087446
647PhosphorylationNPFNRKPSPSASPTV
CCCCCCCCCCCCHHH		34.2225521595
649PhosphorylationFNRKPSPSASPTVRK
CCCCCCCCCCHHHHH		45.7926824392
651PhosphorylationRKPSPSASPTVRKAT
CCCCCCCCHHHHHHC		25.9925521595
653PhosphorylationPSPSASPTVRKATKG
CCCCCCHHHHHHCCC		30.3727742792
658PhosphorylationSPTVRKATKGAKPVR
CHHHHHHCCCCCCCC		32.8030387612
747PhosphorylationHLLVRRESELIYVFK
HHHHCCHHHHEEEEE		35.5716141072
751PhosphorylationRRESELIYVFKQQNL
CCHHHHEEEEEHHCH		16.6829514104
853MalonylationFKTIKVLKFLGNKRE
CCHHHHHHHHCCHHH		41.3426320211
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MILK1_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MILK1_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MILK1_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MILK1_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MILK1_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-494 AND SER-496, ANDMASS SPECTROMETRY.

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