| UniProt ID | MICB_HUMAN | |
|---|---|---|
| UniProt AC | Q29980 | |
| Protein Name | MHC class I polypeptide-related sequence B | |
| Gene Name | MICB {ECO:0000312|EMBL:CAA62823.1} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 383 | |
| Subcellular Localization |
Cell membrane Single-pass type I membrane protein . Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum. |
|
| Protein Description | Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.. | |
| Protein Sequence | MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDESVQSGFLAEGHLDGQPFLRYDRQKRRAKPQGQWAEDVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCEIHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKVLVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHRDAAQLGFQPLMSATGSTGSTEGA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 67 | Ubiquitination | DRQKRRAKPQGQWAE HHHHHCCCCCCCCHH | 35.74 | - | |
| 67 | Ubiquitination | DRQKRRAKPQGQWAE HHHHHCCCCCCCCHH | 35.74 | 21906983 | |
| 67 | Ubiquitination | DRQKRRAKPQGQWAE HHHHHCCCCCCCCHH | 35.74 | 21906983 | |
| 67 | Ubiquitination | DRQKRRAKPQGQWAE HHHHHCCCCCCCCHH | 35.74 | - | |
| 81 | Phosphorylation | EDVLGAKTWDTETED HHHHCCCCCCCCCHH | 28.21 | - | |
| 84 | Phosphorylation | LGAKTWDTETEDLTE HCCCCCCCCCHHHHH | 36.05 | - | |
| 86 | Phosphorylation | AKTWDTETEDLTENG CCCCCCCCHHHHHCC | 36.57 | - | |
| 99 | Phosphorylation | NGQDLRRTLTHIKDQ CCHHHHHHHHHHHCC | 29.58 | - | |
| 101 | Phosphorylation | QDLRRTLTHIKDQKG HHHHHHHHHHHCCCC | 22.42 | - | |
| 104 | Ubiquitination | RRTLTHIKDQKGGLH HHHHHHHHCCCCCCC | 46.64 | - | |
| 104 | Ubiquitination | RRTLTHIKDQKGGLH HHHHHHHHCCCCCCC | 46.64 | - | |
| 107 | Ubiquitination | LTHIKDQKGGLHSLQ HHHHHCCCCCCCCCC | 66.15 | - | |
| 112 | Phosphorylation | DQKGGLHSLQEIRVC CCCCCCCCCCEEEEE | 36.47 | - | |
| 127 | Ubiquitination | EIHEDSSTRGSRHFY EEECCCCCCCCEEEE | 42.89 | - | |
| 147 | Ubiquitination | FLSQNLETQESTVPQ EEECCCCCCCCCCCC | 40.58 | - | |
| 153 | Ubiquitination | ETQESTVPQSSRAQT CCCCCCCCCCHHHHH | 28.55 | 21906983 | |
| 153 | Ubiquitination | ETQESTVPQSSRAQT CCCCCCCCCCHHHHH | 28.55 | 21906983 | |
| 164 | N-linked_Glycosylation | RAQTLAMNVTNFWKE HHHHHHHHHHHHHHH | 31.67 | UniProtKB CARBOHYD | |
| 170 | Ubiquitination | MNVTNFWKEDAMKTK HHHHHHHHHHHHHHH | 41.39 | - | |
| 190 | Ubiquitination | MQADCLQKLQRYLKS HHHHHHHHHHHHHHH | 33.37 | - | |
| 196 | Ubiquitination | QKLQRYLKSGVAIRR HHHHHHHHHCCCCCC | 35.91 | 2190698 | |
| 196 (in isoform 1) | Ubiquitination | - | 35.91 | 21906983 | |
| 196 | Ubiquitination | QKLQRYLKSGVAIRR HHHHHHHHHCCCCCC | 35.91 | 21906983 | |
| 210 | N-linked_Glycosylation | RTVPPMVNVTCSEVS CCCCCEEEEEECEEC | 19.68 | UniProtKB CARBOHYD | |
| 220 | N-linked_Glycosylation | CSEVSEGNITVTCRA ECEECCCEEEEEEEC | 23.78 | UniProtKB CARBOHYD | |
| 256 | Ubiquitination | NTQQWGDVLPDGNGT CCEECCCCCCCCCCE | 8.03 | - | |
| 261 | N-linked_Glycosylation | GDVLPDGNGTYQTWV CCCCCCCCCEEEEEE | 47.19 | UniProtKB CARBOHYD | |
| 297 | O-linked_Glycosylation | HGTHPVPSGKVLVLQ CCCCCCCCCCEEEEE | 52.02 | OGP | |
| 297 | Phosphorylation | HGTHPVPSGKVLVLQ CCCCCCCCCCEEEEE | 52.02 | 22210691 | |
| 305 | Phosphorylation | GKVLVLQSQRTDFPY CCEEEEECCCCCCCH | 19.91 | 22210691 | |
| 334 | Ubiquitination | CVPCCKKKTSAAEGP HHHHHCCCCCCCCCC | 32.96 | - | |
| 345 | Phosphorylation | AEGPELVSLQVLDQH CCCCCEEEEEEECCC | 26.21 | 23312004 | |
| 372 | Phosphorylation | LGFQPLMSATGSTGS HCCCCCCCCCCCCCC | 30.29 | 29485707 | |
| 374 | Phosphorylation | FQPLMSATGSTGSTE CCCCCCCCCCCCCCC | 25.10 | 29485707 | |
| 376 | Phosphorylation | PLMSATGSTGSTEGA CCCCCCCCCCCCCCC | 25.82 | 23186163 | |
| 377 | Phosphorylation | LMSATGSTGSTEGA- CCCCCCCCCCCCCC- | 36.17 | 20363803 | |
| 377 | Phosphorylation | LMSATGSTGSTEGA- CCCCCCCCCCCCCC- | 36.17 | 20363803 | |
| 379 | Phosphorylation | SATGSTGSTEGA--- CCCCCCCCCCCC--- | 24.31 | 26503892 | |
| 379 | Phosphorylation | SATGSTGSTEGA--- CCCCCCCCCCCC--- | 24.31 | 20363803 | |
| 380 | Phosphorylation | ATGSTGSTEGA---- CCCCCCCCCCC---- | 39.52 | 26503892 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MICB_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MICB_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MICB_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| ZCHC8_HUMAN | ZCCHC8 | physical | 22939629 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 180300 | Rheumatoid arthritis (RA) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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