MICA2_HUMAN - dbPTM
MICA2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MICA2_HUMAN
UniProt AC O94851
Protein Name [F-actin]-monooxygenase MICAL2
Gene Name MICAL2
Organism Homo sapiens (Human).
Sequence Length 1124
Subcellular Localization Nucleus .
Protein Description Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA..
Protein Sequence MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMANQLLAKFEESTRNPSLMKQERRVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQFPSVVVTGHVLRELKQVSAGSECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVLWRLQQVEEKILQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFPQNKLLSKGLSHTHPPSPPSRLPSPDPAASSSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEATWQEQEAPRRDTPTESSCAVAAIGTLEGSPPVHFSLPVLHPLLG
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
63MalonylationKVTTWKAKALWYKLD
HHCHHHHHHHHHHCC		40.0426320211
68MethylationKAKALWYKLDKRGSH
HHHHHHHHCCCCCCC		38.33115973009
158PhosphorylationAGSIDHISIRQLQLI
CCCCCCCCHHHHHHH		14.3224719451
228PhosphorylationGADGRRNTLEGFRRK
ECCCCCCCCHHHHHH		25.11-
458UbiquitinationTTPENINKNFEQYTL
CCCCHHHHCCCEEEC		60.2522817900
458 (in isoform 1)Ubiquitination-60.2521906983
458 (in isoform 2)Ubiquitination-60.2521906983
503PhosphorylationYPLERLGSVRRSVNL
CCHHHHCCHHHHCCC		19.6224719451
507PhosphorylationRLGSVRRSVNLSRKE
HHCCHHHHCCCCCCH		12.5622210691
511PhosphorylationVRRSVNLSRKESDIR
HHHHCCCCCCHHCCC		35.7822964224
515PhosphorylationVNLSRKESDIRPSKL
CCCCCCHHCCCHHHH		41.1830266825
520PhosphorylationKESDIRPSKLLTWCQ
CHHCCCHHHHHHHHH		26.5328176443
597AcetylationIPPVTTGKEMASAQE
CCCCCCCHHHHHCCC		42.0719829801
615PhosphorylationLSMVMYLSKFYELFR
HHHHHHHHHHHHHHC		11.8423879269
618PhosphorylationVMYLSKFYELFRGTP
HHHHHHHHHHHCCCC		18.5623879269
624PhosphorylationFYELFRGTPLRPVDS
HHHHHCCCCCCCCHH		18.2023403867
631PhosphorylationTPLRPVDSWRKNYGE
CCCCCCHHHHHHCCC		29.0816675569
634 (in isoform 2)Ubiquitination-48.5421906983
634UbiquitinationRPVDSWRKNYGENAD
CCCHHHHHHCCCCCC		48.5422817900
634 (in isoform 1)Ubiquitination-48.5421906983
643PhosphorylationYGENADLSLAKSSIS
CCCCCCHHHHHHHHH		27.1628555341
646 (in isoform 2)Ubiquitination-50.4521906983
646UbiquitinationNADLSLAKSSISNNY
CCCHHHHHHHHHCCC		50.4522817900
646 (in isoform 1)Ubiquitination-50.4521906983
648PhosphorylationDLSLAKSSISNNYLN
CHHHHHHHHHCCCCC		29.3623186163
653PhosphorylationKSSISNNYLNLTFPR
HHHHHCCCCCEECCC		10.9628796482
657PhosphorylationSNNYLNLTFPRKRTP
HCCCCCEECCCCCCC		30.4425159151
674 (in isoform 2)Phosphorylation-37.4226657352
676 (in isoform 2)Phosphorylation-37.2330266825
678 (in isoform 2)Phosphorylation-38.3430266825
679 (in isoform 2)Phosphorylation-46.3930266825
696PhosphorylationPSNFSSRSLGSNQEC
CCCCCCCCCCCCCCC		38.7423312004
699PhosphorylationFSSRSLGSNQECGSS
CCCCCCCCCCCCCCC		40.4027794612
717O-linked_GlycosylationGNQNKVKSMANQLLA
CCHHHHHHHHHHHHH		26.5630379171
813PhosphorylationPWRARAKSDLQLGGT
CHHHHCCCCCCCCCC		42.44-
820PhosphorylationSDLQLGGTENFATLP
CCCCCCCCCCCCCCC		26.42-
828PhosphorylationENFATLPSTRPRAQA
CCCCCCCCCCHHHHH		39.91-
829PhosphorylationNFATLPSTRPRAQAL
CCCCCCCCCHHHHHH		42.63-
845 (in isoform 6)Phosphorylation-49.5426657352
847 (in isoform 6)Phosphorylation-49.5930266825
849 (in isoform 6)Phosphorylation-34.9030266825
850 (in isoform 6)Phosphorylation-5.8030266825
865PhosphorylationLANREFHTKNIKEKA
HHHHHHHHHCHHHHH		30.9830622161
866 (in isoform 4)Phosphorylation-48.3726657352
868 (in isoform 4)Phosphorylation-6.9430266825
870 (in isoform 4)Phosphorylation-44.1030266825
871 (in isoform 4)Phosphorylation-45.9630266825
908PhosphorylationSPPSRLPSPDPAASS
CCCCCCCCCCCCCCC		46.67-
914PhosphorylationPSPDPAASSSPSTVD
CCCCCCCCCCCCCCC		33.1922468782
916PhosphorylationPDPAASSSPSTVDSA
CCCCCCCCCCCCCCC		22.00-
919PhosphorylationAASSSPSTVDSASPA
CCCCCCCCCCCCCCC		31.5522468782
932PhosphorylationPARKEKKSPSGFHFH
CCCCCCCCCCCCCCC		35.0529214152
956PhosphorylationQLTVGKVSSGIGAAA
CCCCCCCCCCHHHHH		26.7423286773
957PhosphorylationLTVGKVSSGIGAAAE
CCCCCCCCCHHHHHH		37.1023286773
970PhosphorylationAEVLVNLYMNDHRPK
HHHHHHHHCCCCCCC		6.6723286773
981PhosphorylationHRPKAQATSPDLESM
CCCCCCCCCCCHHHH		28.8123286773
982PhosphorylationRPKAQATSPDLESMR
CCCCCCCCCCHHHHH		21.3128348404
991PhosphorylationDLESMRKSFPLNLGG
CHHHHHHHCCCCCCC		23.0226657352
1035PhosphorylationRCSICATTLRLAAYT
HCHHHHHHHHHEEEE		7.4324961811
1092PhosphorylationQEAPRRDTPTESSCA
HHCCCCCCCCHHHHH		30.2324275569
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MICA2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MICA2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MICA2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MICA2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MICA2_HUMAN

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Related Literatures of Post-Translational Modification

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