MICA1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MICA1_MOUSE
• UniProt AC: Q8VDP3
• Protein Name: [F-actin]-monooxygenase MICAL1 {ECO:0000305}
• Gene Name: Mical1
• Organism: Mus musculus (Mouse).
• Sequence Length: 1048
• Subcellular Localization: Cytoplasm . Cytoplasm, cytoskeleton .
• Protein Description: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels. May act as Rab effector protein and play a role in vesicle trafficking..
• Protein Sequence: MASPASTNPAHDHFETFVQAQLCQDVLSSFQGLCRALGVESGGGLSQYHKIKAQLNYWSAKSLWAKLDKRASQPVYQQGQACTNTKCLVVGAGPCGLRAAVELALLGARVVLVEKRIKFSRHNVLHLWPFTIHDLRALGAKKFYGRFCTGTLDHISIRQLQLLLLKVALLLGVEIHWGVKFTGLQPPPRKGSGWRAQLQPNPPAQLASYEFDVLISAAGGKFVPEGFTIREMRGKLAIGITANFVNGRTVEETQVPEISGVARIYNQKFFQSLLKATGIDLENIVYYKDETHYFVMTAKKQCLLRLGVLRQDLSETDQLLGKANVVPEALQRFARAAADFATHGKLGKLEFAQDARGRPDVAAFDFTSMMRAESSARVQEKHGARLLLGLVGDCLVEPFWPLGTGVARGFLAAFDAAWMVKRWAEGAGPLEVLAERESLYQLLSQTSPENMHRNVAQYGLDPATRYPNLNLRAVTPNQVQDLYDMMDKEHAQRKSDEPDSRKTTTGSAGTEELLHWCQEQTAGFPGVHVTDFSSSWADGLALCALVHHLQPGLLEPSELQGMGALEATTWALRVAEHELGITPVLSAQAVMAGSDPLGLIAYLSHFHSAFKNTSHSSGLVSQPSGTPSAILFLGKLQRSLQRTRAKVDEETPSTEEPPVSEPSMSPNTPELSEHQEAGAEELCELCGKHLYILERFCVDGHFFHRSCFCCHTCEATLWPGGYGQHPGDGHFYCLQHLPQEDQKEADNNGSLESQELPTPGDSNMQPDPSSPPVTRVSPVPSPSQPARRLIRLSSLERLRLSSLNIIPDSGAEPPPKPPRSCSDLARESLKSSFVGWGVPVQAPQVPEAIEKGDDEEEEEEEEEEEEEPLPPLEPELEQTLLTLAKNPGAMTKYPTWRRTLMRRAKEEEMKRFCKAQAIQRRLNEIEATMRELEAEGTKLELALRKESSSPEQQKKLWLDQLLRLIQKKNSLVTEEAELMITVQELDLEEKQRQLDHELRGYMNREETMKTEADLQSENQVLRKLLEVVNQRDALIQFQEERRLREMPA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
156	Phosphorylation	TGTLDHISIRQLQLL CCCCCCCCHHHHHHH	14.32	30387612
268	Acetylation	VARIYNQKFFQSLLK HHHHHCHHHHHHHHH	44.50	22826441
475	Phosphorylation	NLNLRAVTPNQVQDL CCCEEECCHHHHHHH	18.61	27180971
616	Phosphorylation	AFKNTSHSSGLVSQP HHCCCCCCCCCCCCC	26.35	-
750	Phosphorylation	KEADNNGSLESQELP HHHCCCCCCCCCCCC	30.96	20531401
753	Phosphorylation	DNNGSLESQELPTPG CCCCCCCCCCCCCCC	33.96	20531401
758	Phosphorylation	LESQELPTPGDSNMQ CCCCCCCCCCCCCCC	53.15	20531401
762	Phosphorylation	ELPTPGDSNMQPDPS CCCCCCCCCCCCCCC	39.87	20531401
769	Phosphorylation	SNMQPDPSSPPVTRV CCCCCCCCCCCCEEE	63.96	20531401
770	Phosphorylation	NMQPDPSSPPVTRVS CCCCCCCCCCCEEEC	38.31	25338131
774	Phosphorylation	DPSSPPVTRVSPVPS CCCCCCCEEECCCCC	31.00	20531401
777	Phosphorylation	SPPVTRVSPVPSPSQ CCCCEEECCCCCCCC	19.52	26824392
781	Phosphorylation	TRVSPVPSPSQPARR EEECCCCCCCCHHHH	37.10	23684622
783	Phosphorylation	VSPVPSPSQPARRLI ECCCCCCCCHHHHHH	53.81	21082442
793	Phosphorylation	ARRLIRLSSLERLRL HHHHHHHHHHHHHCH	24.03	23984901
794	Phosphorylation	RRLIRLSSLERLRLS HHHHHHHHHHHHCHH	38.55	26824392
820	Phosphorylation	PPPKPPRSCSDLARE CCCCCCCCHHHHHHH	24.60	30635358
822	Phosphorylation	PKPPRSCSDLARESL CCCCCCHHHHHHHHH	36.58	25266776
828	Phosphorylation	CSDLARESLKSSFVG HHHHHHHHHHHHCCC	35.23	29176673
895	Phosphorylation	GAMTKYPTWRRTLMR CCCCCCHHHHHHHHH	28.63	27600695
899	Phosphorylation	KYPTWRRTLMRRAKE CCHHHHHHHHHHHHH	19.14	22942356

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MICA1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MICA1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MICA1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MICA1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.