MIC26_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MIC26_MOUSE
• UniProt AC: Q9DCZ4
• Protein Name: MICOS complex subunit Mic26
• Gene Name: Apoo
• Organism: Mus musculus (Mouse).
• Sequence Length: 198
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein . Mitochondrion . Endoplasmic reticulum membrane . Golgi apparatus membrane . Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylat
• Protein Description: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (By similarity). Can induce cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts. [PubMed: 24743151 Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (By similarity]
• Protein Sequence: MFKVIQRSVGPASLSLLTFRVYAAPKKDSPHKSYMKIDELSLYSVPEGQSKYVEEPRTQLEENISQLRHHCEPYTSFCQEIYSHTKPKVDHFVQWGVDNYNYLQNAPPGFFPRLGVIGFAGFVGLLFARGSKIKKLVYPPFFMGLGASVYYPQQAITIAQITGEKLYDWGLRGYIVIEDLWKQNFQKPGNVKNSPGNK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
41	Phosphorylation	YMKIDELSLYSVPEG EECEEEEEEEECCCC		27742792
43	Phosphorylation	KIDELSLYSVPEGQS CEEEEEEEECCCCCC		27742792
44	Phosphorylation	IDELSLYSVPEGQSK EEEEEEEECCCCCCC		23737553
50	Phosphorylation	YSVPEGQSKYVEEPR EECCCCCCCCCCCHH		23737553
51	Ubiquitination	SVPEGQSKYVEEPRT ECCCCCCCCCCCHHH		-
51	Ubiquitination	SVPEGQSKYVEEPRT ECCCCCCCCCCCHHH		-
63	N-linked_Glycosylation	PRTQLEENISQLRHH HHHHHHHHHHHHHHH		-
65	Phosphorylation	TQLEENISQLRHHCE HHHHHHHHHHHHHCC		28464351
65	Ubiquitination	TQLEENISQLRHHCE HHHHHHHHHHHHHCC		22790023
194	Phosphorylation	KPGNVKNSPGNK--- CCCCCCCCCCCC---		25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MIC26_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MIC26_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MIC26_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MIC26_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.