MGT4A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MGT4A_HUMAN
• UniProt AC: Q9UM21
• Protein Name: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
• Gene Name: MGAT4A
• Organism: Homo sapiens (Human).
• Sequence Length: 535
• Subcellular Localization: Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A: Golgi apparatus membrane; Single-pass type II membrane protein.; Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A soluble form: Secreted.
• Protein Description: Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells..
• Protein Sequence: MRLRNGTVATALAFITSFLTLSWYTTWQNGKEKLIAYQREFLALKERLRIAEHRISQRSSELNTIVQQFKRVGAETNGSKDALNKFSDNTLKLLKELTSKKSLQVPSIYYHLPHLLKNEGSLQPAVQIGNGRTGVSIVMGIPTVKREVKSYLIETLHSLIDNLYPEEKLDCVIVVFIGETDIDYVHGVVANLEKEFSKEISSGLVEVISPPESYYPDLTNLKETFGDSKERVRWRTKQNLDYCFLMMYAQEKGIYYIQLEDDIIVKQNYFNTIKNFALQLSSEEWMILEFSQLGFIGKMFQAPDLTLIVEFIFMFYKEKPIDWLLDHILWVKVCNPEKDAKHCDRQKANLRIRFRPSLFQHVGLHSSLSGKIQKLTDKDYMKPLLLKIHVNPPAEVSTSLKVYQGHTLEKTYMGEDFFWAITPIAGDYILFKFDKPVNVESYLFHSGNQEHPGDILLNTTVEVLPFKSEGLEISKETKDKRLEDGYFRIGKFENGVAEGMVDPSLNPISAFRLSVIQNSAVWAILNEIHIKKATN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8 (in isoform 2)	Phosphorylation	-	4.77	-
17	Phosphorylation	TALAFITSFLTLSWY HHHHHHHHHHHHHHH	17.28	-
22	Phosphorylation	ITSFLTLSWYTTWQN HHHHHHHHHHHHCCC	16.89	-
59	O-linked_Glycosylation	EHRISQRSSELNTIV HHHHHHHHHHHHHHH	22.11	55828711
60	O-linked_Glycosylation	HRISQRSSELNTIVQ HHHHHHHHHHHHHHH	48.57	55828717
64	O-linked_Glycosylation	QRSSELNTIVQQFKR HHHHHHHHHHHHHHH	34.84	55828723
77	N-linked_Glycosylation	KRVGAETNGSKDALN HHHCCCCCCCHHHHH	44.22	UniProtKB CARBOHYD
94	Ubiquitination	SDNTLKLLKELTSKK CHHHHHHHHHHHCCC	3.76	29967540
102	Phosphorylation	KELTSKKSLQVPSIY HHHHCCCCCCCCHHH	27.98	22210691
107	Phosphorylation	KKSLQVPSIYYHLPH CCCCCCCHHHHCHHH	25.11	22210691
136	Phosphorylation	GNGRTGVSIVMGIPT CCCCCCEEEEECCCH	15.71	-
143	Phosphorylation	SIVMGIPTVKREVKS EEEECCCHHHHHHHH	36.42	-
197	Phosphorylation	ANLEKEFSKEISSGL HHHHHHHHHHHHCCC	30.39	22817900
219	Phosphorylation	ESYYPDLTNLKETFG HHHCCCCCCHHHHHC	45.98	22817900
222	Ubiquitination	YPDLTNLKETFGDSK CCCCCCHHHHHCCCH	57.70	29967540
254	Ubiquitination	MYAQEKGIYYIQLED EEHHHCCEEEEEECC	3.32	29967540
255	Phosphorylation	YAQEKGIYYIQLEDD EHHHCCEEEEEECCC	11.81	-
256	Phosphorylation	AQEKGIYYIQLEDDI HHHCCEEEEEECCCE	4.73	-
374	Acetylation	SLSGKIQKLTDKDYM HHCCHHHHCCCCCCC	57.75	19813645
376	O-linked_Glycosylation	SGKIQKLTDKDYMKP CCHHHHCCCCCCCCC	48.30	55828877
378	Acetylation	KIQKLTDKDYMKPLL HHHHCCCCCCCCCEE	45.59	19813653
382	Ubiquitination	LTDKDYMKPLLLKIH CCCCCCCCCEEEEEE	26.70	29967540
410 (in isoform 2)	Phosphorylation	-	48.33	24719451
458	N-linked_Glycosylation	HPGDILLNTTVEVLP CCCCEEEECEEEEEC	30.20	UniProtKB CARBOHYD
474	Phosphorylation	KSEGLEISKETKDKR CCCCCCCCHHHCCCC	18.31	28355574
477	Phosphorylation	GLEISKETKDKRLED CCCCCHHHCCCCCCC	48.56	28857561
509	Phosphorylation	DPSLNPISAFRLSVI CCCCCCCCHHHHHHH	23.70	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
474	S	Phosphorylation	Kinase	FAM20C	Q8IXL6	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MGT4A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MGT4A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MGT4A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.