MGST1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MGST1_MOUSE
• UniProt AC: Q91VS7
• Protein Name: Microsomal glutathione S-transferase 1
• Gene Name: Mgst1
• Organism: Mus musculus (Mouse).
• Sequence Length: 155
• Subcellular Localization: Microsome. Mitochondrion outer membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
• Protein Description: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles..
• Protein Sequence: MADLRQLMDNEVLMAFTSYATIILTKMMFMSSATAFQRITNKVFANPEDCAGFGKGENAKKFVRTDEKVERVRRAHLNDLENIVPFLGIGLLYSLSGPDLSTALMHFRIFVGARIYHTIAYLTPLPQPNRGLAFFVGYGVTLSMAYRLLRSRLYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	NEVLMAFTSYATIIL HHHHHHHHHHHHHHH	15.99	24759943
25	Phosphorylation	SYATIILTKMMFMSS HHHHHHHHHHHHHCC	13.39	24759943
31	Phosphorylation	LTKMMFMSSATAFQR HHHHHHHCCHHHHHH	12.93	24759943
32	Phosphorylation	TKMMFMSSATAFQRI HHHHHHCCHHHHHHH	20.18	-
34	Phosphorylation	MMFMSSATAFQRITN HHHHCCHHHHHHHHH	29.92	-
42	Acetylation	AFQRITNKVFANPED HHHHHHHHHCCCHHH	30.04	23576753
42	Ubiquitination	AFQRITNKVFANPED HHHHHHHHHCCCHHH	30.04	-
42	Succinylation	AFQRITNKVFANPED HHHHHHHHHCCCHHH	30.04	24315375
42	Malonylation	AFQRITNKVFANPED HHHHHHHHHCCCHHH	30.04	26320211
50	S-palmitoylation	VFANPEDCAGFGKGE HCCCHHHHCCCCCCC	3.68	28526873
50	S-nitrosylation	VFANPEDCAGFGKGE HCCCHHHHCCCCCCC	3.68	21278135
50	Glutathionylation	VFANPEDCAGFGKGE HCCCHHHHCCCCCCC	3.68	24333276
50	S-nitrosocysteine	VFANPEDCAGFGKGE HCCCHHHHCCCCCCC	3.68	-
55	Malonylation	EDCAGFGKGENAKKF HHHCCCCCCCHHHHH	61.87	26320211
55	Ubiquitination	EDCAGFGKGENAKKF HHHCCCCCCCHHHHH	61.87	-
55	Acetylation	EDCAGFGKGENAKKF HHHCCCCCCCHHHHH	61.87	23576753
60	Ubiquitination	FGKGENAKKFVRTDE CCCCCHHHHHCCCHH	59.32	-
60	Acetylation	FGKGENAKKFVRTDE CCCCCHHHHHCCCHH	59.32	23576753
60	Malonylation	FGKGENAKKFVRTDE CCCCCHHHHHCCCHH	59.32	26320211
61	Ubiquitination	GKGENAKKFVRTDEK CCCCHHHHHCCCHHH	46.83	-
68	Acetylation	KFVRTDEKVERVRRA HHCCCHHHHHHHHHH	52.81	22733758
118	Phosphorylation	VGARIYHTIAYLTPL HCCHHHHHHHHHCCC	7.13	23140645
121	Phosphorylation	RIYHTIAYLTPLPQP HHHHHHHHHCCCCCC	13.78	23140645
123	Phosphorylation	YHTIAYLTPLPQPNR HHHHHHHCCCCCCCC	15.31	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MGST1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
42	K	Acetylation	Acetylation of Lys-42 and Lys-55 is observed in liver mitochondria from fasted mice but not from fed mice.	23576753
55	K	Acetylation	Acetylation of Lys-42 and Lys-55 is observed in liver mitochondria from fasted mice but not from fed mice.	23576753

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MGST1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MGST1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Substrate and functional diversity of lysine acetylation revealed bya proteomics survey.";
Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.;
Mol. Cell 23:607-618(2006).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-42 AND LYS-55, AND MASSSPECTROMETRY.
PubMed: 16916647