dbPTM

MFRN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MFRN1_HUMAN
UniProt AC	Q9NYZ2
Protein Name	Mitoferrin-1
Gene Name	SLC25A37
Organism	Homo sapiens (Human).
Sequence Length	338
Subcellular Localization	Mitochondrion inner membrane Multi-pass membrane protein.
Protein Description	Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity)..
Protein Sequence	MELRSGSVGSQAVARRMDGDSRDGGGGKDATGSEDYENLPTSASVSTHMTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVNVMIMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHRSAISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFLTKRQLENRAPY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	ARRMDGDSRDGGGGK HHHCCCCCCCCCCCC	37.49	-
75	Phosphorylation	SVKTRMQSLSPDPKA HHHHHHHHCCCCHHH	22.82	26074081
77	Phosphorylation	KTRMQSLSPDPKAQY HHHHHHCCCCHHHHH	32.29	26074081
84	Phosphorylation	SPDPKAQYTSIYGAL CCCHHHHHHHHHHHH	13.81	26074081
85	Phosphorylation	PDPKAQYTSIYGALK CCHHHHHHHHHHHHH	9.14	26074081
86	Phosphorylation	DPKAQYTSIYGALKK CHHHHHHHHHHHHHH	14.63	26074081
88	Phosphorylation	KAQYTSIYGALKKIM HHHHHHHHHHHHHHH	8.98	26074081
97	Phosphorylation	ALKKIMRTEGFWRPL HHHHHHHCCCCCCCC	24.07	26074081
121	Phosphorylation	AGPAHAMYFACYENM CCHHHHHHHHHHHHH	6.71	26552605
125	Phosphorylation	HAMYFACYENMKRTL HHHHHHHHHHHHHHH	13.60	26552605
151	Phosphorylation	LANGIAGSMATLLHD HHHCHHHHHHHHHHH	9.02	-
198	Phosphorylation	TEGLGAFYRSYTTQL CCCCCCHHHEEEEEE	9.71	-
325	Phosphorylation	SVYEFFKYFLTKRQL HHHHHHHHHHHHHHH	9.92	-
328	Phosphorylation	EFFKYFLTKRQLENR HHHHHHHHHHHHHHC	17.81	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MFRN1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MFRN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
21	Phosphorylation	15 (6)	I ⇒ V	rs2942194	Mean corpuscular volume	27863252

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MFRN1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MFRN1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-125, AND MASSSPECTROMETRY.	18187866 [Abstract]