MFM3_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MFM3_SCHPO
• UniProt AC: P40849
• Protein Name: M-factor
• Gene Name: mfm3
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 41
• Subcellular Localization: Cell membrane ; Lipid-anchor ; Cytoplasmic side .
• Protein Description: M-factor is a mating pheromone produced by M-type mating cells. All three mfm genes contribute to the production of M-factor..
• Protein Sequence: MDSMANTVSSSVVNTGNKPSETLNKTVKNYTPKVPYMCVIA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Farnesylation	TPKVPYMCVIA---- CCCCCEEEEEC----	1.33	1547790
38	Farnesylation	TPKVPYMCVIA---- CCCCCEEEEEC----	1.33	1547790
38	Methylation	TPKVPYMCVIA---- CCCCCEEEEEC----	1.33	1547790

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MFM3_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MFM3_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MFM3_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of MFM3_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Methylation

"Mating pheromones of the fission yeast Schizosaccharomyces pombe:purification and structural characterization of M-factor and isolationand analysis of two genes encoding the pheromone.";
Davey J.;
EMBO J. 11:951-960(1992).
Cited for: PROTEIN SEQUENCE OF 30-38, ISOPRENYLATION AT CYS-38, AND METHYLATIONAT CYS-38.
PubMed: 1547790

Prenylation

"Mating pheromones of the fission yeast Schizosaccharomyces pombe:purification and structural characterization of M-factor and isolationand analysis of two genes encoding the pheromone.";
Davey J.;
EMBO J. 11:951-960(1992).
Cited for: PROTEIN SEQUENCE OF 30-38, ISOPRENYLATION AT CYS-38, AND METHYLATIONAT CYS-38.
PubMed: 1547790

"Analysis of the structural genes encoding M-factor in the fissionyeast Schizosaccharomyces pombe: identification of a third gene,mfm3.";
Kjaerulff S., Davey J., Nielsen O.;
Mol. Cell. Biol. 14:3895-3905(1994).
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed: 8196631