METL1_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: METL1_ARATH
• UniProt AC: Q94AI4
• Protein Name: Methyltransferase-like protein 1
• Gene Name: EMB1691
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 775
• Protein Description: Probable methyltransferase..
• Protein Sequence: MKKKQEESSLEKLSTWYQDGEQDGGDRSEKRRMSLKASDFESSSRSGGSKSKEDNKSVVDVEHQDRDSKRERDGRERTHGSSSDSSKRKRWDEAGGLVNDGDHKSSKLSDSRHDSGGERVSVSNEHGESRRDLKSDRSLKTSSRDEKSKSRGVKDDDRGSPLKKTSGKDGSEVVREVGRSNRSKTPDADYEKEKYSRKDERSRGRDDGWSDRDRDQEGLKDNWKRRHSSSGDKDQKDGDLLYDRGREREFPRQGRERSEGERSHGRLGGRKDGNRGEAVKALSSGGVSNENYDVIEIQTKPHDYVRGESGPNFARMTESGQQPPKKPSNNEEEWAHNQEGRQRSETFGFGSYGEDSRDEAGEASSDYSGAKARNQRGSTPGRTNFVQTPNRGYQTPQGTRGNRPLRGGKGRPAGGRENQQGAIPMPIMGSPFANLGMPPPSPIHSLTPGMSPIPGTSVTPVFMPPFAPTLIWPGARGVDGNMLPVPPVLSPLPPGPSGPRFPSIGTPPNPNMFFTPPGSDRGGPPNFPGSNISGQMGRGMPSDKTSGGWVPPRGGGPPGKAPSRGEQNDYSQNFVDTGMRPQNFIRELELTNVEDYPKLRELIQKKDEIVSNSASAPMYLKGDLHEVELSPELFGTKFDVILVDPPWEEYVHRAPGVSDSMEYWTFEDIINLKIEAIADTPSFLFLWVGDGVGLEQGRQCLKKWGFRRCEDICWVKTNKSNAAPTLRHDSRTVFQRSKEHCLMGIKGTVRRSTDGHIIHANIDTDVIIAEEPPYG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MKKKQEESSLEKLST CCHHHHHHHHHHHHH	39.20	25561503
9	Phosphorylation	KKKQEESSLEKLSTW CHHHHHHHHHHHHHH	43.77	25561503
121	Phosphorylation	DSGGERVSVSNEHGE CCCCCEEEECCCCCC	26.50	25561503
123	Phosphorylation	GGERVSVSNEHGESR CCCEEEECCCCCCCH	29.06	25561503
129	Phosphorylation	VSNEHGESRRDLKSD ECCCCCCCHHHHHCC	36.89	25561503
160	Phosphorylation	VKDDDRGSPLKKTSG CCCCCCCCCCCCCCC	28.14	30407730
183	Phosphorylation	EVGRSNRSKTPDADY HHHCCCCCCCCCHHH	45.17	23776212
185	Phosphorylation	GRSNRSKTPDADYEK HCCCCCCCCCHHHHH	27.87	23776212
190	Phosphorylation	SKTPDADYEKEKYSR CCCCCHHHHHHHHCC	30.53	23776212
283	Phosphorylation	GEAVKALSSGGVSNE HHHHHHHHCCCCCCC	31.62	27545962
388	Phosphorylation	GRTNFVQTPNRGYQT CCCCCCCCCCCCCCC	19.75	27288362
857	Phosphorylation	----------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------		27545962
858	Phosphorylation	------------------------------------------------------------------------------------------ ------------------------------------------------------------------------------------------		27545962
863	Phosphorylation	----------------------------------------------------------------------------------------------- -----------------------------------------------------------------------------------------------		27545962
868	Phosphorylation	---------------------------------------------------------------------------------------------------- ----------------------------------------------------------------------------------------------------		23111157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of METL1_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of METL1_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of METL1_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of METL1_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-185, AND MASSSPECTROMETRY.
PubMed: 19376835