METE_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: METE_SCHPO
• UniProt AC: Q9UT19
• Protein Name: Probable 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
• Gene Name: met26
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 764
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation..
• Protein Sequence: MVKSAVLGFPRIGKNRELKKATEAYWSGKTSAEELLATAKQLRLEHWKLQKAQGVDIIPSNDFSLYDQIMDHSFSFNVIPPRYRLSGLSSLDTYFAMGRGMQRAATADKAAVDVPAGEMVKWFDSNYHFLRPEVSEETDFKLSSTKALDEFLEAKEAGIITRPVLVGPVTYLFIAKAAKGSSIKPIELLPKLLPVYVELIKKLTEAGAEYIQIDEPILTLDLPQEILASYKEAYETLGKIGKLILTTYFGSLQSNADVLKGLPIAGVHVDVVRAPENLDRALAVLGENQIISVGVVSGRNIWKTDFQKATAIIEKAISAVGSERVQVASSSSILHIPHSLSGEDQINPEIKRWFAFAVEKCAELAILTKAANDGPASVRAELEANAADCKARAESPITNVEAVRERQSKVTPQMHERKSPFETRYAKQQASLKLPLFPTTTIGSFPQTKEIRVTRNRFAKGLISQEEYDAFIRKEISDVVKFQEEVGLDVLVHGEPERNDMVQYFGERMEGFVFTVNGWVQSYGSRCVRPPIIVGDVYRPAPMTVKESQYAQSITSKPMKGMLTAPITILRWSFPRDDVHDSVQAQQIALGLRDEVLDLEKAGIKVIQCDEPALREGLPLRRAEWDEYLKWAIDAFRLATAAVQDDTQIHSHFCYSDFNDIFDAIQRLDADVVSIENSKSDMKLLNVLSRYTSCIGPGLFDIHSPRVPPVSEFKERIDAIVKHVPKDHLWLNPDCGLKTRGWPETTADLKNMIAAAREAREQYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MVKSAVLGFPR ----CCCCHHHCCCC	16.52	24763107
30	Phosphorylation	EAYWSGKTSAEELLA HHHHCCCCCHHHHHH	36.37	25720772
31	Phosphorylation	AYWSGKTSAEELLAT HHHCCCCCHHHHHHH	36.85	25720772
83	Phosphorylation	FNVIPPRYRLSGLSS CCCCCCCCCCCCCCH	22.98	25720772
86	Phosphorylation	IPPRYRLSGLSSLDT CCCCCCCCCCCHHHH	28.79	25720772
89	Phosphorylation	RYRLSGLSSLDTYFA CCCCCCCCHHHHHHH	32.17	25720772
90	Phosphorylation	YRLSGLSSLDTYFAM CCCCCCCHHHHHHHH	34.99	25720772
181	Phosphorylation	IAKAAKGSSIKPIEL EHHHCCCCCCCCHHH	28.34	24763107
182	Phosphorylation	AKAAKGSSIKPIELL HHHCCCCCCCCHHHH	43.21	28889911
395	Phosphorylation	DCKARAESPITNVEA HHHHHCCCCCCCHHH	22.18	28889911
419	Phosphorylation	PQMHERKSPFETRYA CCHHCCCCHHHHHHH	40.83	24763107
423	Phosphorylation	ERKSPFETRYAKQQA CCCCHHHHHHHHHHH	29.38	21712547
439	Phosphorylation	LKLPLFPTTTIGSFP CCCCCCCCCCCCCCC	29.27	29996109
440	Phosphorylation	KLPLFPTTTIGSFPQ CCCCCCCCCCCCCCC	19.36	25720772
441	Phosphorylation	LPLFPTTTIGSFPQT CCCCCCCCCCCCCCC	26.31	28889911
444	Phosphorylation	FPTTTIGSFPQTKEI CCCCCCCCCCCCCEE	29.87	29996109
464	Phosphorylation	RFAKGLISQEEYDAF HHHHHCCCHHHHHHH	36.26	25720772
689	Phosphorylation	MKLLNVLSRYTSCIG HHHHHHHHHHHCCCC	20.96	25720772
693	Phosphorylation	NVLSRYTSCIGPGLF HHHHHHHCCCCCCCC	8.53	25720772
704	Phosphorylation	PGLFDIHSPRVPPVS CCCCCCCCCCCCCHH	18.09	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of METE_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of METE_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of METE_SCHPO !!

Protein-Protein Interaction

Oops, there are no PPI records of METE_SCHPO !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of fission yeast.";
Wilson-Grady J.T., Villen J., Gygi S.P.;
J. Proteome Res. 7:1088-1097(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND THR-441, ANDMASS SPECTROMETRY.
PubMed: 18257517