METE2_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: METE2_ARATH
• UniProt AC: Q9SRV5
• Protein Name: 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 2
• Gene Name: MS2
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 765
• Subcellular Localization: Cytoplasm, cytosol .
• Protein Description: Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation..
• Protein Sequence: MASHIVGYPRMGPKRELKFALESFWDGKSSADDLQKVSADLRSDIWKQMSAAGIKYIPSNTFSHYDQVLDTTAMLGAVPSRYGFTSGEIGLDVYFSMARGNASVPAMEMTKWFDTNYHYIVPELGPEVKFSYASHKAVNEYKEAKALGVETVPVLVGPVSYLLLSKLAKGVDKSFDLLSLLPKILPVYKEVIAELKAAGASWIQLDEPLFVMDLEGHKLQAFSGAYAELESTLSGLNVLVETYFADIPAEAYKTLTSLKGVTAFGFDLVRGTKTIDLIKSGFPQGKYLFAGVVDGRNIWANDLAASLITLQSLEGVVGKDKLVVSTSCSLLHTAVDLINETKLDAEIKSWLAFAAQKVVEVDALAKALAGQTNESFFTANADALSSRRSSPRVTNESVQKAAAALKGSDHRRTTEVSARLDAQQKKLNLPILPTTTIGSFPQTVELRRVRREYKAKKISEEDYVKAIKEEIKKVVDIQEDLDIDVLVHGEPERNDMVEYFGEQLSGFAFTANGWVQSYGSRCVKPPVIYGDVSRPKPMTVFWSSTAQSMTKRPMKGMLTGPVTILNWSFVRNDQPRHETCYQIALAIKDEVEDLEKGGIGVIQIDEAALREGLPLRKAEHSFYLDWAVHSFRITNCGVQDSTQIHTHMCYSNFNDIIHSIIDMDADVITIENSRSDEKLLSVFREGVKYGAGIGPGVYDIHSPRIPSTDEIADRINKMLAVLEQNILWVNPDCGLKTRKYTEVKPALKAMVDAAKLIRSQLGSAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASHIVGYPR -----CCCCCCCCCC		25561503
11	Sulfoxidation	HIVGYPRMGPKRELK CCCCCCCCCCHHHHH		25693801
49	Sulfoxidation	RSDIWKQMSAAGIKY HHHHHHHHHHHCCCC		25693801
103	Phosphorylation	SMARGNASVPAMEMT EHHCCCCCCCHHHHE		23111157
349	Phosphorylation	KLDAEIKSWLAFAAQ CCCHHHHHHHHHHHH		19880383
408	Phosphorylation	AAAALKGSDHRRTTE HHHHHCCCCCCCHHH		29654922
681	Phosphorylation	RSDEKLLSVFREGVK CCCHHHHHHHHHHHC		29654922
698	Phosphorylation	AGIGPGVYDIHSPRI CCCCCCCCCCCCCCC		23776212
702	Phosphorylation	PGVYDIHSPRIPSTD CCCCCCCCCCCCCHH		30291188
750	Sulfoxidation	VKPALKAMVDAAKLI HHHHHHHHHHHHHHH		25693801

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of METE2_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of METE2_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of METE2_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of METE2_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.