MERTK_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MERTK_RAT
• UniProt AC: P57097
• Protein Name: Tyrosine-protein kinase Mer
• Gene Name: Mertk
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 994
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3 (By similarity)..
• Protein Sequence: MVLAPLLLGLLLLSALWNGGTAEKEEEIKPDQPFSGPLPGSLPADHRPFFAPHSSGDQLSPSQTGRSHPAHTATPQMTSAASNLLPPVAFKNTIGRIVLSEHKSVKFNCSINIPNVYQETAGISWWKDGKELLGAHHSITQFYPDEEGVSIIALFSITSVQRSDNGSYICKMKVNDREVVSDPIYVEVQGLPYFTKQPESVNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNENPERSPSVLTVAGLTETAVFSCEAHNDKGLTVSKGVQINIKVIPSPPTEVHILNSTAHSILVSWVPGFDGYSPLQNCSIQVKEADQLSNGSVMVFNTSASPHLYEVQQLQALANYSVTVSCRNEIGWSAVSPWILASTTEGAPAVAPLNITVFLNESSNNLEIRWTKPPIKRQDGELVGYRISHVWESAGTSKELSEEVSQNGSWAQVPVQMHNATCTVRIAVITKGGIGPFSEPVDVAIPEHSRVDYAPSSTPAPGNTESMLIILGCFCGFVLMGLILYLSLAIKRRVQETKFGGAFSEEDSQLVVNYRAKKSFCRRAIELTLQSLGVSEELQNKLEDVVVDRNLLILGKVLGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSLREIEEFLSEAACMKDFNHPNVIRLLGVCIELSSQGIPKPMVILPFMKYGDLHTFLLYSRIESVPKSIPLQTLLKFMVDIAQGMEYLSSRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDDLYEIMYSCWSADPLDRPTFSVLRLQLEKLSESLPDAQDKESIIYINTQLLESCEGLANRSSLAGLDMNIDPDSIIASCTAGAAVSVVMAEVHENNLHEERYILNGGNEEWEDVASTPFATVTAGKDGVLPEDRLTKNGISWSHHSTLPLGSPSPDELLFADDSSGDSEVLM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
108	N-linked_Glycosylation	EHKSVKFNCSINIPN CCCCEEEEEEEECCC	16.95	-
165	N-linked_Glycosylation	TSVQRSDNGSYICKM EEEEECCCCCEEEEE	42.42	-
202	N-linked_Glycosylation	TKQPESVNVTRNTAF CCCCCCEECCCCCEE	38.43	-
210	N-linked_Glycosylation	VTRNTAFNLTCQAVG CCCCCEEEEEEEECC	31.79	-
229	N-linked_Glycosylation	VNIFWVQNSSRVNEN EEEEEEECCCCCCCC	32.12	-
289	N-linked_Glycosylation	PTEVHILNSTAHSIL CCEEEEEECCCCHHH	36.39	-
311	N-linked_Glycosylation	DGYSPLQNCSIQVKE CCCCCCCCCEEEEEE	29.23	-
324	N-linked_Glycosylation	KEADQLSNGSVMVFN EEHHHCCCCCEEEEE	56.18	-
331	N-linked_Glycosylation	NGSVMVFNTSASPHL CCCEEEEECCCCCCE	23.01	-
349	N-linked_Glycosylation	QQLQALANYSVTVSC HHHHHHHCCEEEEEE	30.38	-
384	N-linked_Glycosylation	APAVAPLNITVFLNE CCCCCCEEEEEEEEC	27.16	-
390	N-linked_Glycosylation	LNITVFLNESSNNLE EEEEEEEECCCCCEE	35.32	-
437	N-linked_Glycosylation	LSEEVSQNGSWAQVP HCHHHHHCCCEECCC	38.67	-
449	N-linked_Glycosylation	QVPVQMHNATCTVRI CCCEEECCCEEEEEE	31.44	-
534	Phosphorylation	TKFGGAFSEEDSQLV CCCCCCCCHHHHEEE	39.27	23984901
538	Phosphorylation	GAFSEEDSQLVVNYR CCCCHHHHEEEEEHH	28.79	23984901
740	Phosphorylation	CVADFGLSKKIYSGD EEEEECCCCCCCCCC	32.08	23984901
744	Phosphorylation	FGLSKKIYSGDYYRQ ECCCCCCCCCCCCCC	18.58	-
748	Phosphorylation	KKIYSGDYYRQGRIA CCCCCCCCCCCCCCC	12.22	-
749	Phosphorylation	KIYSGDYYRQGRIAK CCCCCCCCCCCCCCC	10.95	-
851	Ubiquitination	VLRLQLEKLSESLPD HHHHHHHHHHHCCCC	66.94	-
867	Phosphorylation	QDKESIIYINTQLLE CCCCEEEEEEHHHHH	6.10	22276854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MERTK_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MERTK_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MERTK_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MERTK_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.