MEG11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEG11_HUMAN
• UniProt AC: A6BM72
• Protein Name: Multiple epidermal growth factor-like domains protein 11
• Gene Name: MEGF11
• Organism: Homo sapiens (Human).
• Sequence Length: 1044
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Basolateral cell membrane ; Single-pass type I membrane protein . Forms an irregular, mosaic-like adhesion pattern in region of the cell that becomes firmely fixed to the substrate. Localized to p
• Protein Description: May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity)..
• Protein Sequence: MVLSLTGLIAFSFLQATLALNPEDPNVCSHWESYAVTVQESYAHPFDQIYYTRCTDILNWFKCTRHRISYKTAYRRGLRTMYRRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHCSNRCQCQNGALCNPITGACVCAAGFRGWRCEELCAPGTHGKGCQLPCQCRHGASCDPRAGECLCAPGYTGVYCEELCPPGSHGAHCELRCPCQNGGTCHHITGECACPPGWTGAVCAQPCPPGTFGQNCSQDCPCHHGGQCDHVTGQCHCTAGYMGDRCQEECPFGSFGFQCSQHCDCHNGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADCHSITGGCTCAPGFMGEVCAVSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDGTFGLNCSEHCDCSHADGCDPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPGFYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQLCSCANNGTCSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRVCQCQNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQQLCECMNNSTCDHVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISPALGAERHSVGAVTGIMLLLFLIVVLLGLFAWHRRRQKEKGRDLAPRVSYTPAMRMTSTDYSLSGACGMDRRQNTYIMDKGFKDYMKESVCSSSTCSLNSSENPYATIKDPPILTCKLPESSYVEMKSPVHMGSPYTDVPSLSTSNKNIYEVEPTVSVVQEGCGHNSSYIQNAYDLPRNSHIPGHYDLLPVRQSPANGPSQDKQS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
74 (in isoform 4)	Phosphorylation	-	13.18	22210691
270	N-linked_Glycosylation	PPGTFGQNCSQDCPC CCCCCCCCCCCCCCC	27.99	UniProtKB CARBOHYD
531	N-linked_Glycosylation	PDGTFGLNCSEHCDC CCCCCCCCCCCCCCC	27.87	UniProtKB CARBOHYD
825 (in isoform 3)	Phosphorylation	-	6.85	30206219
829 (in isoform 3)	Phosphorylation	-	3.63	22210691
831 (in isoform 3)	Phosphorylation	-	35.63	30206219
855 (in isoform 3)	Phosphorylation	-	0.97	22210691
888	Phosphorylation	RDLAPRVSYTPAMRM CCCCCCCCCCCCCCC	25.27	22210691
889	Phosphorylation	DLAPRVSYTPAMRMT CCCCCCCCCCCCCCC	17.56	22210691
890	Phosphorylation	LAPRVSYTPAMRMTS CCCCCCCCCCCCCCC	9.32	22210691
896	Phosphorylation	YTPAMRMTSTDYSLS CCCCCCCCCCCCCCC	20.36	22210691
897	Phosphorylation	TPAMRMTSTDYSLSG CCCCCCCCCCCCCCC	15.22	22210691
898	Phosphorylation	PAMRMTSTDYSLSGA CCCCCCCCCCCCCCC	29.77	22210691
914	Phosphorylation	GMDRRQNTYIMDKGF CCCCCCCEEEECCCH	13.19	-
915	Phosphorylation	MDRRQNTYIMDKGFK CCCCCCEEEECCCHH	11.20	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEG11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEG11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEG11_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MEG11_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.