MED8_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED8_ARATH
• UniProt AC: Q4V3C1
• Protein Name: Mediator of RNA polymerase II transcription subunit 8
• Gene Name: MED8
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 524
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Regulator of both plant defense and flowering time. Involved in pollen tube growth..
• Protein Sequence: METQPQQPPPPPVAEKLNPKLEKELNLESLKTRAVSLAKAIARILEDFDAYGRTNTTPKWQDILGQYSMVNLELFNIVEEVKRVSNAFVVLPKNVNAMNAAILPVMLSSKLLPEMETDDNAKREQLLQGVQSLPIPMQIERLKARMDMIAAACENAERVLADTRKAYGFGTRQGPSMLPTMDKGQAAKIQEQEKMLRDAVNDGKGTQLPPDQRQITTALPPHLADVLIINDAGKIALPGQSNNINNQGMMQVSGTQFVGRSAASPSGPNFDNTTSPLPYSNSPRATGMVNVPSPQHQIQQQQFQQQQQRSKLMQLPQHQQQQLLAQQQQQLRQSSMQGLGQSQIPALHDMHGQAQQKFQTSHGQHQMPYSQPMGAHQQFQARQLSGGHIQHSMSQGQLNPAMNRHLNQFSGGANSALFTSAQGSPSSQMIPNMSSMQSQTLVPRMQQFGVSGTNPQRSHSSQMLGDQMFNTSGMMQTQQTQIQQSQQQQQQQQQGGYGNMQTNQQSLQPNNMMQNAQQRHQNPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------METQPQQP -------CCCCCCCC	13.03	22223895
273	Phosphorylation	SGPNFDNTTSPLPYS CCCCCCCCCCCCCCC	30.41	30407730
274	Phosphorylation	GPNFDNTTSPLPYSN CCCCCCCCCCCCCCC	34.30	30407730
275	Phosphorylation	PNFDNTTSPLPYSNS CCCCCCCCCCCCCCC	23.54	30407730
280	Phosphorylation	TTSPLPYSNSPRATG CCCCCCCCCCCCCCC	28.97	30407730
282	Phosphorylation	SPLPYSNSPRATGMV CCCCCCCCCCCCCCC	15.15	30407730
293	Phosphorylation	TGMVNVPSPQHQIQQ CCCCCCCCHHHHHHH	32.67	27531888
392	Phosphorylation	SGGHIQHSMSQGQLN CCCCCCCCCCCCCCC	12.07	25561503
394	Phosphorylation	GHIQHSMSQGQLNPA CCCCCCCCCCCCCHH	33.89	25561503

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED8_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED8_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED8_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of MED8_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.