MED26_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED26_MOUSE
• UniProt AC: Q7TN02
• Protein Name: Mediator of RNA polymerase II transcription subunit 26
• Gene Name: Med26
• Organism: Mus musculus (Mouse).
• Sequence Length: 588
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity)..
• Protein Sequence: MTAAPASPQQMRDRLLQAIDSQSNIRNMVAVLEVISSLERYPITKEALEETRLGKLINDVRKKTKNEELAKRAKRLLRSWQKLIEPVHQNEVALRALAGAAGSANGGAHNCRPEMGVAGAPKSIHDLKNRNDIQRLPGQRLDRLGSRKRRGDQRDLGHPGPPHKVSKGSPDPLVPNASPLPTNGISGSPESLPSPLDGSGHLGPDGSRLEPSDNEKHSTKIPVNAVRPRPSSPGLGKPPVPCLQTKAAQLQQLDRADESPGPPYPRGSSRCSFSPRNSRHEGSFSRHRSSYIPKGQVSSPSPWPQPPDNTQVPSPLPLAQPPTPPVRRQELLPNAESPVHWPEQSEGHPRLTGPACRAGFSPDSSKADSDATSSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIRPLTQKEPVRADSPVPTEQLPRTELEQQEVKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMAEYLKQEESSRQGARQPHVLLPLPTPTDLPGLTREVTQDDLDRIQAQQWPGVNGCEDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTAAPASPQ ------CCCCCCCHH	31.37	30635358
7	Phosphorylation	-MTAAPASPQQMRDR -CCCCCCCHHHHHHH	23.37	25266776
37	Phosphorylation	AVLEVISSLERYPIT HHHHHHHHHHCCCCC	24.11	21183079
166	Phosphorylation	PGPPHKVSKGSPDPL CCCCCCCCCCCCCCC	35.78	25293948
169	Phosphorylation	PHKVSKGSPDPLVPN CCCCCCCCCCCCCCC	29.84	25293948
178	Phosphorylation	DPLVPNASPLPTNGI CCCCCCCCCCCCCCC	33.34	25293948
194	Phosphorylation	GSPESLPSPLDGSGH CCCCCCCCCCCCCCC	43.31	25338131
231	Phosphorylation	NAVRPRPSSPGLGKP CCCCCCCCCCCCCCC	50.90	26643407
232	Phosphorylation	AVRPRPSSPGLGKPP CCCCCCCCCCCCCCC	26.18	26824392
245	Phosphorylation	PPVPCLQTKAAQLQQ CCCCCHHHHHHHHHH	15.09	25168779
259	Phosphorylation	QLDRADESPGPPYPR HHHHCCCCCCCCCCC	35.39	28066266
274	Phosphorylation	GSSRCSFSPRNSRHE CCCCCCCCCCCCCCC	13.47	23527152
298	Phosphorylation	YIPKGQVSSPSPWPQ CCCCCCCCCCCCCCC	28.75	25777480
299	Phosphorylation	IPKGQVSSPSPWPQP CCCCCCCCCCCCCCC	30.46	25777480
301	Phosphorylation	KGQVSSPSPWPQPPD CCCCCCCCCCCCCCC	41.36	25777480
310	Phosphorylation	WPQPPDNTQVPSPLP CCCCCCCCCCCCCCC	38.02	25777480
314	Phosphorylation	PDNTQVPSPLPLAQP CCCCCCCCCCCCCCC	39.97	25777480
323	Phosphorylation	LPLAQPPTPPVRRQE CCCCCCCCCCCCHHH	47.08	25777480
337	Phosphorylation	ELLPNAESPVHWPEQ HHCCCCCCCCCCCCC	29.79	26824392
345	Phosphorylation	PVHWPEQSEGHPRLT CCCCCCCCCCCCCCC	43.83	28066266
352	Phosphorylation	SEGHPRLTGPACRAG CCCCCCCCCCCCCCC	42.26	21454597
361	Phosphorylation	PACRAGFSPDSSKAD CCCCCCCCCCCHHCC	27.21	26824392
364	Phosphorylation	RAGFSPDSSKADSDA CCCCCCCCHHCCCCC	36.80	28833060
365	Phosphorylation	AGFSPDSSKADSDAT CCCCCCCHHCCCCCC	38.96	23984901
369	Phosphorylation	PDSSKADSDATSSGG CCCHHCCCCCCCCCC	33.72	25777480
372	Phosphorylation	SKADSDATSSGGSDS HHCCCCCCCCCCCCC	28.54	25777480
390	Phosphorylation	KRYRPRDYTVNLDGQ CCCCCCCEEECCCHH	17.54	21454597
414	Phosphorylation	RLKERKLTFDPMTRQ ECCCCCCCCCCCCCC	29.09	27600695
435	Phosphorylation	KEPVRADSPVPTEQL CCCCCCCCCCCHHHC	27.15	27087446
439	Phosphorylation	RADSPVPTEQLPRTE CCCCCCCHHHCCCHH	36.28	28833060
455	Phosphorylation	EQQEVKASLQSPFEQ HHHHHHHHHCCHHHH	22.63	29233185
458	Phosphorylation	EVKASLQSPFEQTNW HHHHHHCCHHHHCCH	36.53	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED26_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED26_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED26_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MED26_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.