| UniProt ID | MED25_MOUSE | |
|---|---|---|
| UniProt AC | Q8VCB2 | |
| Protein Name | Mediator of RNA polymerase II transcription subunit 25 | |
| Gene Name | Med25 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 745 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription (By similarity).. | |
| Protein Sequence | MVPGSEGPARAGGLVADVVFVIEGTANLGPYFEELRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPALLEPLQQPADVSQDPRHMVLVRGLVLPVGGSSTSGSLQTKQAVPLPPAPASAATLSAAPPQALPPVPPQYQVPGNLSAAQVAAQNAVEAAKSQKAGLGPRFSPINPLQQAAPGVGPPFSQAPAPPLAPVPPGAPKPPPASQPSLVSTVAPGPVLAAPAQPGAPSLAGTVTPGGVNGPSAAQLGGPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPVLGPILEEQARPPQNLLQLRAPQPQPQGAVGASAATGQPQPQGATQAPTGAPQGPPGAAPGPPPSGPILRPQNPGANPQLRSLLLNPAPPQTGVPPPQASLHHLQPPGAPTLLPPHQSMGQPQLGPQLLHPPPAQSWPTQLPQRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 197 | Ubiquitination | ALRLLFEKAAPPALL HHHHHHHHCCCHHHH | 42.38 | 22790023 | |
| 197 (in isoform 3) | Ubiquitination | - | 42.38 | 22790023 | |
| 274 (in isoform 3) | Ubiquitination | - | 5.81 | - | |
| 484 | Ubiquitination | NKDLESLKGLYRIMG CCCHHHHHHHHHHHC | 57.03 | 22790023 | |
| 484 (in isoform 3) | Ubiquitination | - | 57.03 | 22790023 | |
| 515 | Phosphorylation | VRVLMLLYSSKKKIF HHHHHHHHHCCCEEE | 13.62 | 29472430 | |
| 516 | Phosphorylation | RVLMLLYSSKKKIFM HHHHHHHHCCCEEEE | 35.33 | 29472430 | |
| 517 | Phosphorylation | VLMLLYSSKKKIFMG HHHHHHHCCCEEEEE | 34.63 | 29472430 | |
| 561 (in isoform 3) | Ubiquitination | - | 33.95 | - | |
| 585 | Methylation | PQNLLQLRAPQPQPQ CCCEEEECCCCCCCC | 31.12 | 30988077 | |
| 723 | Asymmetric dimethylarginine | MLLSGGPRGPVPQPG EEECCCCCCCCCCCC | 66.38 | - | |
| 723 | Methylation | MLLSGGPRGPVPQPG EEECCCCCCCCCCCC | 66.38 | 24129315 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MED25_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MED25_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MED25_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MED25_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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