MED24_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED24_MOUSE
• UniProt AC: Q99K74
• Protein Name: Mediator of RNA polymerase II transcription subunit 24
• Gene Name: Med24
• Organism: Mus musculus (Mouse).
• Sequence Length: 987
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). Required for basal and activator-dependent transcription..
• Protein Sequence: MKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSCSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLSCHGKAEECIGLCRALLSALHWLLRCTAASAERLQEGLEAGTPAPGEKQLALCLQCLEKTLSSTKNRALLHIAKLEEASSWTAIEHSLLKLGEILANLSNPQLRSQAERCGTLIRSIPSMLSVHSEQLHKTGFPTIHALILLEGTMNLTGEMQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTQELKWTAFTYLKIPQVLVKLKKYFHGEKDFTEDVNCAFEFLLKLTPLLDKADQRCNCDCTNFLLQECNKQGLLSEVNFASLVGKRTADRDPQLKSSENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHGSGESTKTASVRALLFDISFLMLCHVAQTYGSEVILSESSSGEEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVESLVALLNNSSEMKLVQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMNSILEHMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTDIFAKVLEKGWVDSRSIHILDTLLHMGGVYWFCNNLIKELLKETRKEHTLRAVQLLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSSYSSHKGQASSRQKKRHREDIEDYVSLFPVEDMQPSKLMRLLSSSDDDANILSSPTDRSMNSSLSASQLHTVNMRDPLNRVLANLFLLISSILGSRTAGPHTQFVQWFMEECVGCLEQDSRGSILQFMPFTTVSELVKVSAMSSPKVVLAITDLSLPLGRQVAAKAIAAL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
420	Ubiquitination	PTVTNILKTMDADHS CCHHHHHHHCCCCCC	37.70	-
860	Phosphorylation	SKLMRLLSSSDDDAN HHHHHHHCCCCCCCC	32.18	27087446
861	Phosphorylation	KLMRLLSSSDDDANI HHHHHHCCCCCCCCC	37.44	27087446
862	Phosphorylation	LMRLLSSSDDDANIL HHHHHCCCCCCCCCC	41.50	27742792
870	Phosphorylation	DDDANILSSPTDRSM CCCCCCCCCCCCCHH	30.40	22942356
871	Phosphorylation	DDANILSSPTDRSMN CCCCCCCCCCCCHHC	28.51	27087446
873	Phosphorylation	ANILSSPTDRSMNSS CCCCCCCCCCHHCCC	46.09	22942356
940	Phosphorylation	LEQDSRGSILQFMPF HHCCCCCCEECCCCC	21.00	25293948
948	Phosphorylation	ILQFMPFTTVSELVK EECCCCCCCHHHHHH	22.03	25293948
949	Phosphorylation	LQFMPFTTVSELVKV ECCCCCCCHHHHHHH	23.55	25293948
951	Phosphorylation	FMPFTTVSELVKVSA CCCCCCHHHHHHHHH	24.11	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED24_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED24_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED24_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MED24_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.