MED17_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED17_MOUSE
• UniProt AC: Q8VCD5
• Protein Name: Mediator of RNA polymerase II transcription subunit 17
• Gene Name: Med17
• Organism: Mus musculus (Mouse).
• Sequence Length: 649
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)..
• Protein Sequence: MSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGPDGDAPDWGGAGADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQSPQTLQLISKKKSLAGAAQILLKGAERLTKSVAENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPSLQLSISLCHSSDDKKSQKCAAEKPGQEDHLYVLEHNLHLLIREFHKQTLSSIVMPHPASAPFGHKRMRLSGPQAFDKNEINSIQSTEGLLEKIIKQAKHIFLRSRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQVRVVHRDGRVIMLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDSKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	GVRAVRISIESACEK CCCEEEEEHHHHHHH	15.11	25266776
13	Phosphorylation	AVRISIESACEKQVQ EEEEEHHHHHHHHHH	36.23	28066266
50	Phosphorylation	LAQRIDFSQGSGSEE HHHHCCCCCCCCCHH	29.86	19060867
53	Phosphorylation	RIDFSQGSGSEEEEA HCCCCCCCCCHHHHH	31.35	21659605
55	Phosphorylation	DFSQGSGSEEEEAAG CCCCCCCCHHHHHCC	43.46	21659605
129	Phosphorylation	FMTLDPVSQDALPPK CCCCCCCCCCCCCCC	27.94	22871156
387	Phosphorylation	FHKQTLSSIVMPHPA HHHHHHHHHCCCCCC	23.47	-
395	Phosphorylation	IVMPHPASAPFGHKR HCCCCCCCCCCCCCC	40.71	-
568	Phosphorylation	IGNASAITVASPSGD CCCEEEEEEECCCCC	15.10	-
645	Phosphorylation	ELLMSALSPCLL--- HHHHHHHHCCCC---	17.18	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
53	S	Phosphorylation	Kinase	CK2A1	P68400	PSP
568	T	Phosphorylation	Kinase	P38A	Q16539	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED17_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED17_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MED17_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.