MED13_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED13_MOUSE
• UniProt AC: Q5SWW4
• Protein Name: Mediator of RNA polymerase II transcription subunit 13
• Gene Name: Med13
• Organism: Mus musculus (Mouse).
• Sequence Length: 2171
• Subcellular Localization: Nucleus.
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)..
• Protein Sequence: MSSSFVSNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGKDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHVTLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCGLKEMSEEKQDDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPAPSSVGASHCSASCLGIHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFSTDSTSHHGGKIPRKLANHVVDRVWQECNMNRLQNKRKYSATSSGLCEEETADKIGCWDFVEATQRTSCSCLRHKSLKTRNTGQQGQAPSLGQQQQVLPKHKTNEKQDKSEKPQKRPLTPFHHRVSVSDEIGMDTDSASQRLVISAADSQVRFSNIRTNDVAKTPQMHGTELANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPTKPMEDRIDSLSQSFPPPFQEAVEPTVYVGTAVSLEEDEANVAWKYYKVPKKKDVEFLPPQLPNDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDEIVQQYQIKNQYLSAIASDTEQEPKIDPYAFVEGDEEFIFTDKKDRQNSEREAGKKHKVEDGTSAVTVLSHEEDAMSLFSPSKQDAPRPTNHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSASGSDDKASSKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSVDTAPGGTVLEGNSSSVGTQFRIEVEEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSHCLPPIKLPEECVYRQSWTVGKLDLLPSGPSMPFIKEGDGSNLDQDYGPAYTPQTHASFGMPPSSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRASSVENVNGGLKESEKVPDELILLLQDQCTNLFSPFGAADQDPFPKVGISSNWVRVEERDCCSDCCLALEHGRQFMDNMSGGKVDEALVRSSCLHPWAKQNDASVQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWEKLMLEPYGSQRDIAYVVLCPENEALLNGARSFFRDLTAIYESCRLGQHRPISRLLTDGIMKVGATASKKLSEKFVTEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPPNQSLVTAPQMTNTGNANAPSATLASAASSTMTMTSGVPISTSVATANSTLTTTSSSSSSSLSSGVSSNKLPSFPPFGSMNTSGTGSMSAQASTVQSGQLGGQQSSSLQAAGISGESASLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIVPCQYLLQPVKHDDRQIYSQHLKSLAFSVFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTPQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTASPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAVQDRRSCLPVHFVVLNQLYNFIMNML

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
152	Sumoylation	KPYEKDEKPINKSEH CCCCCCCCCCCHHCC	62.42	28289178
321	Phosphorylation	STRDPAMSSVTLTPP CCCCCCCCEEEECCC	24.62	29472430
322	Phosphorylation	TRDPAMSSVTLTPPT CCCCCCCEEEECCCC	13.16	29472430
324	Phosphorylation	DPAMSSVTLTPPTSP CCCCCEEEECCCCCH	27.19	29472430
326	Phosphorylation	AMSSVTLTPPTSPEE CCCEEEECCCCCHHH	20.18	27087446
329	Phosphorylation	SVTLTPPTSPEEVQT EEEECCCCCHHHHCC	59.11	27087446
330	Phosphorylation	VTLTPPTSPEEVQTV EEECCCCCHHHHCCC	35.77	19060867
336	Phosphorylation	TSPEEVQTVDPQSAQ CCHHHHCCCCHHHHH	31.86	29472430
394	Phosphorylation	RLQNKRKYSATSSGL HHHCCCCCCCCCCCC	13.94	25619855
395	Phosphorylation	LQNKRKYSATSSGLC HHCCCCCCCCCCCCC	28.27	25619855
397	Phosphorylation	NKRKYSATSSGLCEE CCCCCCCCCCCCCCH	19.93	25619855
398	Phosphorylation	KRKYSATSSGLCEEE CCCCCCCCCCCCCHH	23.33	25619855
399	Phosphorylation	RKYSATSSGLCEEET CCCCCCCCCCCCHHH	31.28	25619855
474	Phosphorylation	KPQKRPLTPFHHRVS CCCCCCCCCCCCCCC	26.96	24899341
481	Phosphorylation	TPFHHRVSVSDEIGM CCCCCCCCCCCCCCC	18.83	25338131
483	Phosphorylation	FHHRVSVSDEIGMDT CCCCCCCCCCCCCCC	23.24	25338131
500	Phosphorylation	ASQRLVISAADSQVR HHHHHHHEHHCCCEE	15.21	28066266
504	Phosphorylation	LVISAADSQVRFSNI HHHEHHCCCEEECCC	26.33	28066266
519	Phosphorylation	RTNDVAKTPQMHGTE CCCCCCCCCCCCCCC	14.71	21659605
525	Phosphorylation	KTPQMHGTELANSPQ CCCCCCCCCCCCCCC	17.10	26745281
530	Phosphorylation	HGTELANSPQPPPLS CCCCCCCCCCCCCCC	21.21	27087446
537	Phosphorylation	SPQPPPLSPHPCDVV CCCCCCCCCCCCCCC	27.26	27087446
549	Phosphorylation	DVVDEGVTKTPSTPQ CCCCCCCCCCCCCCC	39.80	23984901
551	Phosphorylation	VDEGVTKTPSTPQSQ CCCCCCCCCCCCCHH	17.07	26643407
553	Phosphorylation	EGVTKTPSTPQSQHF CCCCCCCCCCCHHCC	58.93	28609623
554	Phosphorylation	GVTKTPSTPQSQHFY CCCCCCCCCCHHCCC	26.93	28609623
557	Phosphorylation	KTPSTPQSQHFYQMP CCCCCCCHHCCCCCC	27.16	28609623
561	Phosphorylation	TPQSQHFYQMPTPDP CCCHHCCCCCCCCCC	11.19	28609623
565	Phosphorylation	QHFYQMPTPDPLVPT HCCCCCCCCCCCCCC	34.67	28609623
572	Phosphorylation	TPDPLVPTKPMEDRI CCCCCCCCCCHHHHH	40.06	28609623
683	Phosphorylation	QIKNQYLSAIASDTE HHHHHHHHHHHCCCC	16.82	30635358
687	Phosphorylation	QYLSAIASDTEQEPK HHHHHHHCCCCCCCC	38.66	30635358
689	Phosphorylation	LSAIASDTEQEPKID HHHHHCCCCCCCCCC	36.75	30635358
746	Phosphorylation	SHEEDAMSLFSPSKQ CCCHHHHHHCCCCCC	28.16	29472430
749	Phosphorylation	EDAMSLFSPSKQDAP HHHHHHCCCCCCCCC	33.29	25266776
751	Phosphorylation	AMSLFSPSKQDAPRP HHHHCCCCCCCCCCC	41.57	29472430
825	Phosphorylation	LDPLSCISTADLHKM CCCCCCEEHHHHHHH	23.13	-
838	Phosphorylation	KMYPTPPSLEQHIMG HHCCCCCCHHHHHCC	45.82	26643407
847	Phosphorylation	EQHIMGFSPMNMNNK HHHHCCCCCCCCCCC	19.94	26643407
889	Phosphorylation	EVEEGFCSPKPSEIK EEECCCCCCCCHHCC	33.43	25521595
893	Phosphorylation	GFCSPKPSEIKDFSY CCCCCCCHHCCCCEE	59.07	25159016
1010	Phosphorylation	PSTPRFPTPRTPRTP CCCCCCCCCCCCCCC	23.77	23684622
1013	Phosphorylation	PRFPTPRTPRTPRTP CCCCCCCCCCCCCCC	20.51	23684622
1016	Phosphorylation	PTPRTPRTPRTPRGA CCCCCCCCCCCCCCC	20.51	23684622
1019	Phosphorylation	RTPRTPRTPRGAGGP CCCCCCCCCCCCCCC	20.67	29899451
1028	Phosphorylation	RGAGGPASAQGSVKY CCCCCCCCCCCCEEE	25.02	27149854
1032	Phosphorylation	GPASAQGSVKYENSD CCCCCCCCEEECCCC	11.89	29550500
1169	Phosphorylation	FEALRASSVENVNGG HHHHHHHCCEECCCC	32.25	30482847
1447	Ubiquitination	GNNEAFSKLKLYAQV CCCHHHHHHHHHHHH	43.09	22790023
1733	Phosphorylation	STNVKTLTGFGPGLA CCCCEECCCCCCCHH	35.38	24759943
1743	Phosphorylation	GPGLAMETALKSPDR CCCHHHHHHHHCCCC	24.97	24759943
1758	Phosphorylation	PECIRLYTPPFILAP CHHHHHCCCCEEEEE	29.13	-
2045	Phosphorylation	QGTDRLLSTESHDEV CCCCCCCCCCCHHHH	34.42	24224561
2046	Phosphorylation	GTDRLLSTESHDEVT CCCCCCCCCCHHHHH	41.29	24224561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED13_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED13_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED13_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MED13_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.