MED12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MED12_MOUSE
• UniProt AC: A2AGH6
• Protein Name: Mediator of RNA polymerase II transcription subunit 12
• Gene Name: Med12
• Organism: Mus musculus (Mouse).
• Sequence Length: 2190
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway (By similarity)..
• Protein Sequence: MAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVIAAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPAKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKNEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMSTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQMLRQQQQQQQQQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Acetylation	SYEHRPLKRLRLGPP CCCCCCCCCCCCCCC	52.66	23806337
70	Phosphorylation	NFNPAKISSNFSSII CCCHHHHCCCHHHHH	20.65	25293948
71	Phosphorylation	FNPAKISSNFSSIIA CCHHHHCCCHHHHHH	45.42	25293948
74	Phosphorylation	AKISSNFSSIIAEKL HHHCCCHHHHHHHHH	25.52	25293948
75	Phosphorylation	KISSNFSSIIAEKLR HHCCCHHHHHHHHHC	17.55	25293948
80	Acetylation	FSSIIAEKLRCNTLS HHHHHHHHHCCCCCC	32.01	23806337
80	Ubiquitination	FSSIIAEKLRCNTLS HHHHHHHHHCCCCCC	32.01	22790023
94	Phosphorylation	SDTGRRKSLMNQKDN CCCCCCHHHHCCCCC	30.92	24719451
137	Phosphorylation	AKKVPIFSKKEEVFG HHHCCCCCCHHHHHH	43.46	-
166	Phosphorylation	LIKMTCAYYAAMSET HHHHHHHHHHHHCCC	8.86	-
188	Phosphorylation	ADPFTEWTQIITKYL CCCHHHHHHHHHHHH	12.03	22871156
636	Phosphorylation	APGPRPPSPFDDPTD CCCCCCCCCCCCCCC	40.66	26824392
642	Phosphorylation	PSPFDDPTDDPERKE CCCCCCCCCCHHHHH	61.09	22942356
666	Phosphorylation	EDPGLSESMDIDPSS CCCCCCCCCCCCCCC	20.55	-
689	Phosphorylation	KPDFSLFSPTMPCEG CCCCCCCCCCCCCCC	25.42	29550500
691	Phosphorylation	DFSLFSPTMPCEGKG CCCCCCCCCCCCCCC	32.33	29550500
699	Phosphorylation	MPCEGKGSPSPEKPD CCCCCCCCCCCCCCC	26.20	26824392
701	Phosphorylation	CEGKGSPSPEKPDVE CCCCCCCCCCCCCCH	47.60	23684622
815	Ubiquitination	LGGEDGQKRRRNRPE CCCCCCCCCCCCCCC	54.09	22790023
989	Ubiquitination	SCSHLKSKFGELFSD HHHHHHHHHHHHHHH	56.66	22790023
1000	Ubiquitination	LFSDFCSKVKNTIYC HHHHHHHHCCCEEEE	59.41	22790023
1195	Ubiquitination	PCQSDGNKPTVGIRS CCCCCCCCCCCCCHH	47.82	22790023
1239	Phosphorylation	GDAELKGSGFTVPGG CCCCCCCCCEECCCC	29.19	25777480
1242	Phosphorylation	ELKGSGFTVPGGTEE CCCCCCEECCCCCCC	29.35	25777480
1247	Phosphorylation	GFTVPGGTEELPEEE CEECCCCCCCCCCCC	32.00	25777480
1259	Phosphorylation	EEEGGGGSSGRRQGG CCCCCCCCCCCCCCC	32.66	25777480
1260	Phosphorylation	EEGGGGSSGRRQGGR CCCCCCCCCCCCCCC	39.32	25777480
1270	Phosphorylation	RQGGRNISVETASLD CCCCCCCEEEEEHHH	19.90	-
1420	Phosphorylation	KTKPVLSSLERSGVW CCCCCHHHHHHCCCE	30.04	24704852
1773	Acetylation	PEPPKTDKPGAAPPS CCCCCCCCCCCCCCC	51.05	23806337
1780	Phosphorylation	KPGAAPPSTEERKKK CCCCCCCCHHHHHHH	47.60	25338131
1800	Acetylation	KRSQPATKNEDYGMG CCCCCCCCCCCCCCC	61.52	23806337
1856	Dimethylation	PLPAGGPRVDPYRPV CCCCCCCCCCCCCCC	49.06	-
1856	Methylation	PLPAGGPRVDPYRPV CCCCCCCCCCCCCCC	49.06	54540757
1861	Dimethylation	GPRVDPYRPVRLPMQ CCCCCCCCCCCCCCC	28.73	-
1861	Methylation	GPRVDPYRPVRLPMQ CCCCCCCCCCCCCCC	28.73	54540761
1864	Methylation	VDPYRPVRLPMQKLP CCCCCCCCCCCCCCC	35.44	54540769
1864	Dimethylation	VDPYRPVRLPMQKLP CCCCCCCCCCCCCCC	35.44	-
1897	Phosphorylation	LEPSSYKTSVYRQQQ CCCCCCCCCCHHCCC	18.39	25777480
1898	Phosphorylation	EPSSYKTSVYRQQQP CCCCCCCCCHHCCCC	17.01	25777480
1900	Phosphorylation	SSYKTSVYRQQQPTV CCCCCCCHHCCCCCC	11.50	25777480
1901	Methylation	SYKTSVYRQQQPTVP CCCCCCHHCCCCCCC	26.19	24129315
1901	Asymmetric dimethylarginine	SYKTSVYRQQQPTVP CCCCCCHHCCCCCCC	26.19	-
1906	Phosphorylation	VYRQQQPTVPQGQRL CHHCCCCCCCHHHHH	40.24	25777480
1912	Methylation	PTVPQGQRLRQQLQA CCCCHHHHHHHHHHH	38.37	24129315
1912	Dimethylation	PTVPQGQRLRQQLQA CCCCHHHHHHHHHHH	38.37	-
1914	Methylation	VPQGQRLRQQLQAKI CCHHHHHHHHHHHHH	25.12	30762589
1914	Dimethylation	VPQGQRLRQQLQAKI CCHHHHHHHHHHHHH	25.12	-
1999	Methylation	PTRHLQQRPSGYVHQ CCCHHHCCCCCCCCC	17.87	-
1999	Asymmetric dimethylarginine	PTRHLQQRPSGYVHQ CCCHHHCCCCCCCCC	17.87	-
2020	Asymmetric dimethylarginine	HGLTSTQRFSHQTLQ CCCCCCCCCCCHHHC	34.81	-
2020	Methylation	HGLTSTQRFSHQTLQ CCCCCCCCCCCHHHC	34.81	-
2176	Phosphorylation	RQLQQQLSNTQPQPS HHHHHHHHCCCCCCC	33.23	25266776
2178	Phosphorylation	LQQQLSNTQPQPSTN HHHHHHCCCCCCCCC	37.95	22871156

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MED12_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MED12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MED12_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MED12_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.