| UniProt ID | MDHM1_ARATH | |
|---|---|---|
| UniProt AC | Q9ZP06 | |
| Protein Name | Malate dehydrogenase 1, mitochondrial {ECO:0000305} | |
| Gene Name | At1g53240 | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 341 | |
| Subcellular Localization | Mitochondrion matrix . | |
| Protein Description | Catalyzes a reversible NAD-dependent dehydrogenase reaction involved in central metabolism and redox homeostasis between organelle compartments (Probable). Required for carbon dioxide and energy partitioning in leaves. May limit photorespiration during the dark phase. [PubMed: 20876337] | |
| Protein Sequence | MFRSMLVRSSASAKQAVIRRSFSSGSVPERKVAILGAAGGIGQPLALLMKLNPLVSSLSLYDIANTPGVAADVGHINTRSEVVGYMGDDNLAKALEGADLVIIPAGVPRKPGMTRDDLFNINAGIVKNLCTAIAKYCPHALINMISNPVNSTVPIAAEIFKKAGMYDEKKLFGVTTLDVVRARTFYAGKANVPVAEVNVPVIGGHAGVTILPLFSQATPQANLSSDILTALTKRTQDGGTEVVEAKAGKGSATLSMAYAGALFADACLKGLNGVPDVIECSYVQSTITELPFFASKVRLGKNGVEEVLDLGPLSDFEKEGLEALKPELKSSIEKGVKFANQ | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 21 | Phosphorylation | KQAVIRRSFSSGSVP HHHHHHHHCCCCCCC | 21.45 | 19376835 | |
| 23 | Phosphorylation | AVIRRSFSSGSVPER HHHHHHCCCCCCCHH | 34.73 | 23111157 | |
| 24 | Phosphorylation | VIRRSFSSGSVPERK HHHHHCCCCCCCHHH | 32.83 | 19376835 | |
| 26 | Phosphorylation | RRSFSSGSVPERKVA HHHCCCCCCCHHHEE | 36.12 | 19376835 | |
| 86 | Sulfoxidation | RSEVVGYMGDDNLAK HHHHEEEECCHHHHH | 3.79 | 23289948 | |
| 131 | Phosphorylation | GIVKNLCTAIAKYCP HHHHHHHHHHHHHCC | 25.02 | 19880383 | |
| 165 | Sulfoxidation | EIFKKAGMYDEKKLF HHHHHCCCCCCCCCC | 4.56 | 25693801 | |
| 235 | Phosphorylation | LTALTKRTQDGGTEV HHHHHHHCCCCCCEE | 32.35 | 22092075 | |
| 314 | Phosphorylation | VLDLGPLSDFEKEGL HHHCCCCHHHHHHHH | 43.30 | 19880383 | |
| 325 | Acetylation | KEGLEALKPELKSSI HHHHHHHCHHHHHHH | 43.42 | 24727099 | |
| 329 | Acetylation | EALKPELKSSIEKGV HHHCHHHHHHHHHHC | 40.26 | 24727099 | |
| 334 | Acetylation | ELKSSIEKGVKFANQ HHHHHHHHHCCCCCC | 68.30 | 24727099 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MDHM1_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MDHM1_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MDHM1_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MDHM1_ARATH !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23, AND MASSSPECTROMETRY. | |
