MDHC_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MDHC_RAT
• UniProt AC: O88989
• Protein Name: Malate dehydrogenase, cytoplasmic
• Gene Name: Mdh1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 334
• Subcellular Localization: Cytoplasm.
• Protein Sequence: MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLQDVIATDKEEVAFKDLDVAVLVGSMPRREGMERKDLLKANVKIFKSQGAALEKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKSQIALKLGVTADDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFITTVQQRGAAVIKARKLSSAMSAAKAISDHIRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKETAFEFLSSA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSEPIRVLV ------CCCCEEEEE	52.67	-
89	Phosphorylation	DVAVLVGSMPRREGM CEEEHCCCCCCCCCC	20.38	30181290
103	Acetylation	MERKDLLKANVKIFK CCHHHHHHHHHHHHH	45.25	22902405
107	Acetylation	DLLKANVKIFKSQGA HHHHHHHHHHHHCCH	42.08	22902405
110	Acetylation	KANVKIFKSQGAALE HHHHHHHHHCCHHHH	45.39	22902405
110	Succinylation	KANVKIFKSQGAALE HHHHHHHHHCCHHHH	45.39	-
110	Succinylation	KANVKIFKSQGAALE HHHHHHHHHCCHHHH	45.39	-
111	Phosphorylation	ANVKIFKSQGAALEK HHHHHHHHCCHHHHH	24.09	25575281
118	Ubiquitination	SQGAALEKYAKKSVK HCCHHHHHHHCCCCE	51.89	-
118	Acetylation	SQGAALEKYAKKSVK HCCHHHHHHHCCCCE	51.89	22902405
119	Phosphorylation	QGAALEKYAKKSVKV CCHHHHHHHCCCCEE	17.80	22609512
121	Acetylation	AALEKYAKKSVKVIV HHHHHHHCCCCEEEE	42.35	-
135	Phosphorylation	VVGNPANTNCLTASK EECCCCCCCCCCCCC	29.43	25575281
137	S-nitrosylation	GNPANTNCLTASKSA CCCCCCCCCCCCCCC	3.17	22178444
137	S-nitrosocysteine	GNPANTNCLTASKSA CCCCCCCCCCCCCCC	3.17	-
139	Phosphorylation	PANTNCLTASKSAPS CCCCCCCCCCCCCCC	30.96	25575281
141	Phosphorylation	NTNCLTASKSAPSIP CCCCCCCCCCCCCCC	23.16	28689409
142	Ubiquitination	TNCLTASKSAPSIPK CCCCCCCCCCCCCCC	48.44	-
154	S-nitrosylation	IPKENFSCLTRLDHN CCCCCCCHHHHCCCC	3.83	22178444
154	S-nitrosocysteine	IPKENFSCLTRLDHN CCCCCCCHHHHCCCC	3.83	-
164	Ubiquitination	RLDHNRAKSQIALKL HCCCCHHHCHHHHHH	39.39	-
164	Acetylation	RLDHNRAKSQIALKL HCCCCHHHCHHHHHH	39.39	22902405
179	Acetylation	GVTADDVKNVIIWGN CCCHHHCCEEEEECC	53.11	22902405
188	Phosphorylation	VIIWGNHSSTQYPDV EEEECCCCCCCCCCC	38.80	21738781
189	Phosphorylation	IIWGNHSSTQYPDVN EEECCCCCCCCCCCC	16.39	21738781
190	Phosphorylation	IWGNHSSTQYPDVNH EECCCCCCCCCCCCC	34.83	21738781
192	Phosphorylation	GNHSSTQYPDVNHAK CCCCCCCCCCCCCCE	11.07	30181290
199	Acetylation	YPDVNHAKVKLQGKE CCCCCCCEEEECCEE	32.14	22902405
205	Ubiquitination	AKVKLQGKEVGVYEA CEEEECCEEEEEEEE	35.94	-
205	Acetylation	AKVKLQGKEVGVYEA CEEEECCEEEEEEEE	35.94	22902405
210	Phosphorylation	QGKEVGVYEALKDDS CCEEEEEEEECCCCC	6.91	30181290
214	Succinylation	VGVYEALKDDSWLKG EEEEEECCCCCCCCC	67.54	26843850
214	Succinylation	VGVYEALKDDSWLKG EEEEEECCCCCCCCC	67.54	-
214	Acetylation	VGVYEALKDDSWLKG EEEEEECCCCCCCCC	67.54	22902405
217	Phosphorylation	YEALKDDSWLKGEFI EEECCCCCCCCCCCE	44.43	24945867
220	Acetylation	LKDDSWLKGEFITTV CCCCCCCCCCCEECH	50.57	22902405
230	Methylation	FITTVQQRGAAVIKA CEECHHHHCHHHHHH	21.45	-
236	Acetylation	QRGAAVIKARKLSSA HHCHHHHHHHHHHHH	35.22	22902405
241	Phosphorylation	VIKARKLSSAMSAAK HHHHHHHHHHHHHHH	21.06	23991683
242	Phosphorylation	IKARKLSSAMSAAKA HHHHHHHHHHHHHHH	38.13	23991683
245	Phosphorylation	RKLSSAMSAAKAISD HHHHHHHHHHHHHHH	25.45	23298284
295	Acetylation	FPVVIKNKTWKFVEG CCEEEECCCEEEECC	51.24	22902405
298	Succinylation	VIKNKTWKFVEGLPI EEECCCEEEECCCCC	44.77	-
298	Succinylation	VIKNKTWKFVEGLPI EEECCCEEEECCCCC	44.77	-
298	Acetylation	VIKNKTWKFVEGLPI EEECCCEEEECCCCC	44.77	22902405
309	Phosphorylation	GLPINDFSREKMDLT CCCCCCCCHHHHCCC	42.25	-
312	Acetylation	INDFSREKMDLTAKE CCCCCHHHHCCCHHH	36.28	22902405
318	Acetylation	EKMDLTAKELTEEKE HHHCCCHHHHHHHHH	48.28	22902405
318	Succinylation	EKMDLTAKELTEEKE HHHCCCHHHHHHHHH	48.28	-
318	Succinylation	EKMDLTAKELTEEKE HHHCCCHHHHHHHHH	48.28	-
332	Phosphorylation	ETAFEFLSSA----- HHHHHHHHCC-----	29.55	27097102
333	Phosphorylation	TAFEFLSSA------ HHHHHHHCC------	39.90	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
241	S	Phosphorylation	Kinase	PRKG1	P00516	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
118	K	Acetylation	Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MDHC_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MDHC_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.