MDGA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MDGA2_HUMAN
• UniProt AC: Q7Z553
• Protein Name: MAM domain-containing glycosylphosphatidylinositol anchor protein 2
• Gene Name: MDGA2
• Organism: Homo sapiens (Human).
• Sequence Length: 956
• Subcellular Localization: Cell membrane ; Lipid-anchor, GPI-anchor .
• Protein Description: May be involved in cell-cell interactions..
• Protein Sequence: MDLLYGLVWLLTVLLEGISGQGVYAPPTVRIVHSGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVFNETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQFYYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLRPQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCVTTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKSTNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLRSSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSSTVPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYDGTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDRSVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSIINEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAYRLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDSTIRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPNADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYGQHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGIEGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLISILSPRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
51	Phosphorylation	RYSERVYTIREGETL EECCCEEEEECCCEE	15.65	24719451
92	N-linked_Glycosylation	FQDSSVFNETLRITN HCCCHHHCCEEEEEE	38.91	UniProtKB CARBOHYD
118	Phosphorylation	KAENGLGSPAIKSIR ECCCCCCCCCCCEEE	19.05	-
123	Phosphorylation	LGSPAIKSIRVDVYY CCCCCCCEEEEEEEE	14.98	-
182	Phosphorylation	QEVLLQGSDKGVEIY CEEEECCCCCCCEEE	24.16	28450419
213	N-linked_Glycosylation	LRPQDYANYSCIASV CCHHHCCCCHHHEEH	24.03	UniProtKB CARBOHYD
232	Phosphorylation	NIPDKMVSFRLSNKT CCCCCEEEEECCCCC	10.93	27762562
237	N-linked_Glycosylation	MVSFRLSNKTASPSI EEEEECCCCCCCCCE	50.73	UniProtKB CARBOHYD
241	Phosphorylation	RLSNKTASPSIKLLV ECCCCCCCCCEEEEE	25.14	24719451
282	Ubiquitination	LTWVRSFGTLPEKTV EEEEEEECCCCCCEE	27.82	23000965
337	Ubiquitination	ALKKGRFWITPDPYH HHHCCCEEECCCCCC	7.68	23000965
339	Phosphorylation	KKGRFWITPDPYHKD HCCCEEECCCCCCCC	16.54	22210691
366	Phosphorylation	CQVEAVPSEELTFSW EEEEECCCCCEEEEE	36.78	-
434	N-linked_Glycosylation	SDISIDVNISSSTVP EEEEEEEECCCCCCC	25.36	UniProtKB CARBOHYD
439	Phosphorylation	DVNISSSTVPPNLTV EEECCCCCCCCCCCC	38.69	25332170
443	N-linked_Glycosylation	SSSTVPPNLTVPQEK CCCCCCCCCCCCCCC	42.12	UniProtKB CARBOHYD
493	Ubiquitination	MPDGSMQMESYDGTL CCCCCEEEEEECCCE	2.50	23000965
504	N-linked_Glycosylation	DGTLRIVNVSREMSG CCCEEEEEECHHHCC	24.55	UniProtKB CARBOHYD
506	Phosphorylation	TLRIVNVSREMSGMY CEEEEEECHHHCCCE	19.81	24719451
510	Phosphorylation	VNVSREMSGMYRCQT EEECHHHCCCEEEEC	18.69	25072903
513	Phosphorylation	SREMSGMYRCQTSQY CHHHCCCEEEECCCC	16.26	25072903
567	Phosphorylation	SCRVLRAYPIRVLTY EEEEEECCCEEEEEE	7.86	-
573	Phosphorylation	AYPIRVLTYEWRLGN CCCEEEEEEEEECCC	19.28	24719451
585	Phosphorylation	LGNKLLRTGQFDSQE CCCEEECCCCCCCHH	34.99	-
610	N-linked_Glycosylation	NENYGVYNCSIINEA CCCCEEEEEEEEECC	15.62	UniProtKB CARBOHYD
642	Phosphorylation	FYYDTYNPVWQNRHR EEEECCCHHHCCCCC	20.50	24719451
703	N-linked_Glycosylation	KGELITYNLTELIKP CCCEEEEECCCCCCC	31.66	UniProtKB CARBOHYD
722	Ubiquitination	VRLTPLTKFGEGDST EEEEECCCCCCCCCE	60.08	23000965
746	Ubiquitination	VNPHLREFHCGFEDG CCHHHCEEECCCCCC	4.70	23000965
784	Phosphorylation	NTKYTPNTGPNADRS CCCCCCCCCCCCCCC	56.04	-
798	Phosphorylation	SGSKEGFYMYIETSR CCCCCEEEEEEECCC	10.40	-
800	Phosphorylation	SKEGFYMYIETSRPR CCCEEEEEEECCCCC	5.57	24719451
931	GPI-anchor	LATKNSVDGAVGILV HHHCCCCCHHHHHHH	38.87	-
953	Phosphorylation	IVLISILSPRR---- HHHHHHHCCCC----	18.07	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MDGA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MDGA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MDGA2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MDGA2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.