MCR_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MCR_RAT
• UniProt AC: P22199
• Protein Name: Mineralocorticoid receptor
• Gene Name: Nr3c2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 981
• Subcellular Localization: Cytoplasm. Nucleus . Endoplasmic reticulum membrane; Peripheral membrane protein. Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane (B
• Protein Description: Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels..
• Protein Sequence: METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTTENNYMEIVNVSCVSGAIPNNSTQGSSKEKHELLPYIQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVRDAEYTYDQQNQQGSLSPTKIYQNMEQLVKFYKENGHRSSTLSAMSRPLRSFMPDSAASMNGGALRAIVKSPIICHEKSSSVSSPLNMASSVCSPVGINSMSSSTTSFGSFPVHSPITQGTSLTCSPSVENRGSRSHSPTHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVPLRSSVSSPANLNNSRCSVSSPSNNTNNRSTLSSPTASTVGSIGSPISNAFSYATSGASAGAGAIQDVVPSPDTHEKGAHDVPFPKTEEVEKAISNGVTGPLNIVQYIKSEPDGAFSSSCLGGNSKISPSSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGSCEDSAFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSPRDQSFQHLSSFPPVNTLVESWKPHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSALVPQLTSITHALTPSPAMILENIEPETVYAGYDNSKPDTAESLLSTLNRLAAKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQLLYFAPDLVFNEEKMHQSAMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIITDQLPKVESGNAKPLYFHRK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----METKGYHSLP -----CCCCCCCCCC	28.59	25575281
8	Phosphorylation	METKGYHSLPEGLDM CCCCCCCCCCCCCCH	36.82	25575281
127	Phosphorylation	DQQNQQGSLSPTKIY CCCCCCCCCCHHHHH	22.72	28432305
129	Phosphorylation	QNQQGSLSPTKIYQN CCCCCCCCHHHHHHC	32.02	22108457
131	Phosphorylation	QQGSLSPTKIYQNME CCCCCCHHHHHHCHH	27.05	28432305
183	Phosphorylation	ALRAIVKSPIICHEK HHHHHHCCCEECCCC	15.50	29779826
248	Phosphorylation	VENRGSRSHSPTHAS CCCCCCCCCCCCCHH	29.98	23984901
250	Phosphorylation	NRGSRSHSPTHASNV CCCCCCCCCCCHHHC	32.51	23984901
252	Phosphorylation	GSRSHSPTHASNVGS CCCCCCCCCHHHCCC	32.84	23984901
255	Phosphorylation	SHSPTHASNVGSPLS CCCCCCHHHCCCCCC	25.17	23984901
259	Phosphorylation	THASNVGSPLSSPLS CCHHHCCCCCCCCHH	20.56	25575281
262	Phosphorylation	SNVGSPLSSPLSSMK HHCCCCCCCCHHHCC	33.04	25575281
263	Phosphorylation	NVGSPLSSPLSSMKS HCCCCCCCCHHHCCC	37.23	25575281
266	Phosphorylation	SPLSSPLSSMKSPIS CCCCCCHHHCCCCCC	31.60	25575281
267	Phosphorylation	PLSSPLSSMKSPISS CCCCCHHHCCCCCCC	37.60	25575281
270	Phosphorylation	SPLSSMKSPISSPPS CCHHHCCCCCCCCCC	20.87	30181290
273	Phosphorylation	SSMKSPISSPPSHCS HHCCCCCCCCCCCCC	39.93	30181290
274	Phosphorylation	SMKSPISSPPSHCSV HCCCCCCCCCCCCCC	41.36	30181290
277	Phosphorylation	SPISSPPSHCSVKSP CCCCCCCCCCCCCCC	40.27	30181290
283	Phosphorylation	PSHCSVKSPVSSPNN CCCCCCCCCCCCCCC	28.51	22673903
287	Phosphorylation	SVKSPVSSPNNVPLR CCCCCCCCCCCCCCC	31.70	22673903
295	Phosphorylation	PNNVPLRSSVSSPAN CCCCCCCCCCCCCCC	42.65	27097102
296	Phosphorylation	NNVPLRSSVSSPANL CCCCCCCCCCCCCCC	21.42	27097102
298	Phosphorylation	VPLRSSVSSPANLNN CCCCCCCCCCCCCCC	32.33	27097102
299	Phosphorylation	PLRSSVSSPANLNNS CCCCCCCCCCCCCCC	26.35	27097102
306	Phosphorylation	SPANLNNSRCSVSSP CCCCCCCCCCCCCCC	33.32	28689409
311	Phosphorylation	NNSRCSVSSPSNNTN CCCCCCCCCCCCCCC	21.90	27097102
312	Phosphorylation	NSRCSVSSPSNNTNN CCCCCCCCCCCCCCC	30.14	27097102
700	Phosphorylation	PPPPPPQSPEEGTTY CCCCCCCCCCCCCEE	39.80	30181290
705	Phosphorylation	PQSPEEGTTYIAPTK CCCCCCCCEEECCCC	21.50	30181290
706	Phosphorylation	QSPEEGTTYIAPTKE CCCCCCCEEECCCCC	24.64	30181290
707	Phosphorylation	SPEEGTTYIAPTKEP CCCCCCEEECCCCCC	8.57	30181290
711	Phosphorylation	GTTYIAPTKEPSVNS CCEEECCCCCCCCCC	38.73	30181290
779 (in isoform 3)	Ubiquitination	-	42.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MCR_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MCR_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MCR_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MCR_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.