dbPTM

MCRI1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MCRI1_HUMAN
UniProt AC	C9JLW8
Protein Name	Mapk-regulated corepressor-interacting protein 1 {ECO:0000303\|PubMed:25728771}
Gene Name	MCRIP1 {ECO:0000303\|PubMed:25728771, ECO:0000312\|HGNC:HGNC:28007}
Organism	Homo sapiens (Human).
Sequence Length	97
Subcellular Localization	Nucleus . Cytoplasm, Stress granule .
Protein Description	The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. [PubMed: 25728771]
Protein Sequence	MTSSPVSRVVYNGKRTSSPRSPPSSSEIFTPAHEENVRFIYEAWQGVERDLRGQVPGGERGLVEEYVEKVPNPSLKTFKPIDLSDLKRRSTQDAKKS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
2	Phosphorylation	------MTSSPVSRV ------CCCCCCCEE	29255136
3	Phosphorylation	-----MTSSPVSRVV -----CCCCCCCEEE	25849741
4	Phosphorylation	----MTSSPVSRVVY ----CCCCCCCEEEE	25849741
7	Phosphorylation	-MTSSPVSRVVYNGK -CCCCCCCEEEECCC	26074081
11	Phosphorylation	SPVSRVVYNGKRTSS CCCCEEEECCCCCCC	26074081
14	Acetylation	SRVVYNGKRTSSPRS CEEEECCCCCCCCCC	25953088
16	Phosphorylation	VVYNGKRTSSPRSPP EEECCCCCCCCCCCC	25159151
17	Phosphorylation	VYNGKRTSSPRSPPS EECCCCCCCCCCCCC	23927012
18	Phosphorylation	YNGKRTSSPRSPPSS ECCCCCCCCCCCCCC	23927012
21	Phosphorylation	KRTSSPRSPPSSSEI CCCCCCCCCCCCCCC	29255136
24	Phosphorylation	SSPRSPPSSSEIFTP CCCCCCCCCCCCCCC	22167270
25	Phosphorylation	SPRSPPSSSEIFTPA CCCCCCCCCCCCCCC	30278072
26	Phosphorylation	PRSPPSSSEIFTPAH CCCCCCCCCCCCCCC	23927012
30	Phosphorylation	PSSSEIFTPAHEENV CCCCCCCCCCCHHHH	23927012
41	Phosphorylation	EENVRFIYEAWQGVE HHHHHHHHHHHCCCC	21945579
66	Phosphorylation	ERGLVEEYVEKVPNP CCCHHHHHHHCCCCC	29978859
74	Phosphorylation	VEKVPNPSLKTFKPI HHCCCCCCCCCCCCC	29978859
76	Ubiquitination	KVPNPSLKTFKPIDL CCCCCCCCCCCCCCH	21890473
79	Acetylation	NPSLKTFKPIDLSDL CCCCCCCCCCCHHHH	19608861
84	Phosphorylation	TFKPIDLSDLKRRST CCCCCCHHHHHHHCH	22199227
87	Acetylation	PIDLSDLKRRSTQDA CCCHHHHHHHCHHHH	26051181

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
21	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
21	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
30	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
30	T	Phosphorylation	Kinase	MAPK3	P27361	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MCRI1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MCRI1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MCRI1_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MCRI1_HUMAN

Related Literatures of Post-Translational Modification