dbPTM

MCIN_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MCIN_HUMAN
UniProt AC	D6RGH6
Protein Name	Multicilin
Gene Name	MCIDAS
Organism	Homo sapiens (Human).
Sequence Length	385
Subcellular Localization	Nucleus . Excluded from the nucleolus.
Protein Description	Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway. [PubMed: 25048963 Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1]
Protein Sequence	MQACGGGAAGRRAFDSICPNRMLALPGRALLCKPGKPERKFAPPRKFFPGCTGGSPVSVYEDPPDAEPTALPALTTIDLQDLADCSSLLGSDAPPGGDLAASQNHSHQTEADFNLQDFRDTVDDLISDSSSMMSPTLASGDFPFSPCDISPFGPCLSPPLDPRALQSPPLRPPDVPPPEQYWKEVADQNQRALGDALVENNQLHVTLTQKQEEIASLKERNVQLKELASRTRHLASVLDKLMITQSRDCGAAAEPFLLKAKAKRSLEELVSAAGQDCAEVDAILREISERCDEALQSRDPKRPRLLPEPANTDTRPGNLHGAFRGLRTDCSRSALNLSHSELEEGGSFSTRIRSHSTIRTLAFPQGNAFTIRTANGGYKFRWVPS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
167	Phosphorylation	LDPRALQSPPLRPPD CCHHHCCCCCCCCCC	25159151
236	Phosphorylation	SRTRHLASVLDKLMI HHHHHHHHHHHHHHH	-
244	Phosphorylation	VLDKLMITQSRDCGA HHHHHHHHCCCCCCC	22210691
246	Phosphorylation	DKLMITQSRDCGAAA HHHHHHCCCCCCCCC	22210691
312	Phosphorylation	LLPEPANTDTRPGNL CCCCCCCCCCCCCCC	28555341
338	Phosphorylation	SRSALNLSHSELEEG CCHHHHCCHHHHCCC	28555341
370	Phosphorylation	FPQGNAFTIRTANGG ECCCCEEEEEECCCC	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of MCIN_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of MCIN_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MCIN_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MCIN_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MCIN_HUMAN

Related Literatures of Post-Translational Modification