| UniProt ID | MCCA_ARATH | |
|---|---|---|
| UniProt AC | Q42523 | |
| Protein Name | Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial | |
| Gene Name | MCCA | |
| Organism | Arabidopsis thaliana (Mouse-ear cress). | |
| Sequence Length | 734 | |
| Subcellular Localization | Mitochondrion matrix. | |
| Protein Description | Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.. | |
| Protein Sequence | MSMMTVWALRRNVRRKNHSMLVRYISGSASMKPKEQCIEKILVANRGEIACRIMRTAKRLGIQTVAVYSDADRDSLHVKSADEAVRIGPPSARLSYLSGVTIMEAAARTGAQAIHPGYGFLSESSDFAQLCEDSGLTFIGPPASAIRDMGDKSASKRIMGAAGVPLVPGYHGHEQDIDHMKSEAEKIGYPIIIKPTHGGGGKGMRIVQSGKDFADSFLGAQREAAASFGVNTILLEKYITRPRHIEVQIFGDKHGNVLHLYERDCSVQRRHQKIIEEAPAPNISEKFRANLGQAAVSAARAVGYYNAGTVEFIVDTESDQFYFMEMNTRLQVEHPVTEMIVGQDLVEWQIRVANGEPLPLSQSEVPMSGHAFEARIYAENVPKGFLPATGVLNHYRPVAVSPSVRVETGVEQGDTVSMHYDPMIAKLVVWGGNRGEALVKLKDCLSNFQVAGVPTNINFLQKLASHKEFAVGNVETHFIEHHKSDLFADESNPAATEVAYKAVKHSAALVAACISTIEHSTWNESNHGKVPSIWYSNPPFRVHHEAKQTIELEWNNECEGTGSNLISLGVRYQPDGSYLIEEGNDSPSLELRVTRAGKCDFRVEAAGLSMNVSLAAYLKDGYKHIHIWHGSEHHQFKQKVGIEFSEDEEGVQHRTSSETSSHPPGTIVAPMAGLVVKVLVENEAKVDQGQPILVLEAMKMEHVVKAPSSGSIQDLKVKAGQQVSDGSALFRIKG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 645 | Phosphorylation | QKVGIEFSEDEEGVQ HHHCCCCCCCCCCCE | 31.20 | 19376835 | |
| 655 | Phosphorylation | EEGVQHRTSSETSSH CCCCEECCCCCCCCC | 34.18 | 25368622 | |
| 656 | Phosphorylation | EGVQHRTSSETSSHP CCCEECCCCCCCCCC | 26.57 | 25368622 | |
| 657 | Phosphorylation | GVQHRTSSETSSHPP CCEECCCCCCCCCCC | 44.26 | 25368622 | |
| 659 | Phosphorylation | QHRTSSETSSHPPGT EECCCCCCCCCCCCC | 37.16 | 25368622 | |
| 660 | Phosphorylation | HRTSSETSSHPPGTI ECCCCCCCCCCCCCE | 23.69 | 25368622 | |
| 661 | Phosphorylation | RTSSETSSHPPGTIV CCCCCCCCCCCCCEE | 47.64 | 25368622 | |
| 666 | Phosphorylation | TSSHPPGTIVAPMAG CCCCCCCCEEECCCC | 20.32 | 25368622 | |
| 699 | N6-biotinyllysine | ILVLEAMKMEHVVKA EEEEEEECCEEEEEC | 48.46 | - | |
| 699 | Biotinylation | ILVLEAMKMEHVVKA EEEEEEECCEEEEEC | 48.46 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MCCA_ARATH !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MCCA_ARATH !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MCCA_ARATH !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MCCA_ARATH !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks."; Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.; Plant Physiol. 150:889-903(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-645, AND MASSSPECTROMETRY. | |
