| UniProt ID | MBRL_MOUSE | |
|---|---|---|
| UniProt AC | Q8CIV2 | |
| Protein Name | Membralin | |
| Gene Name | Tmem259 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 574 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Multi-pass membrane protein . |
|
| Protein Description | May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.. | |
| Protein Sequence | MSEHAAAPGPGPNGGGGGGAAPVRGPRGPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDRWPREGVLRVEVRHNSSRAPVILQFCDGGLGGLELEPGGLELEEEELTVEMFTNSSIKFELDIEPKVFKPQSGADALNDSQDFPFPETPAKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILTVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQTPPLGPGTPTALPDDLNNNSGSPATPDPSPPLALGPSSSPAPTGGASGPGSLGAGASVSGSDLGWVAETAAIISDASFLSGLSASLLERRPTAPSTPDSSRPDPGVPLEDAPAPAGS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MSEHAAAPG ------CCCCCCCCC | 37.78 | - | |
| 2 | Phosphorylation | ------MSEHAAAPG ------CCCCCCCCC | 37.78 | 25338131 | |
| 180 | N-linked_Glycosylation | QSGADALNDSQDFPF CCCCCCCCCCCCCCC | 48.92 | 19349973 | |
| 259 | Phosphorylation | GYDDILMSSVKGLAE CCHHHHHHHHHHHHH | 28.65 | 28059163 | |
| 260 | Phosphorylation | YDDILMSSVKGLAEN CHHHHHHHHHHHHHC | 17.55 | 28059163 | |
| 293 | Phosphorylation | VSMWMARTSYLAAFV HHHHHHHHHHHHHHH | 16.52 | 26643407 | |
| 294 | Phosphorylation | SMWMARTSYLAAFVI HHHHHHHHHHHHHHH | 16.76 | 26643407 | |
| 295 | Phosphorylation | MWMARTSYLAAFVIM HHHHHHHHHHHHHHH | 10.35 | 26643407 | |
| 549 | Phosphorylation | SLLERRPTAPSTPDS HHHHHCCCCCCCCCC | 49.76 | 26824392 | |
| 552 | Phosphorylation | ERRPTAPSTPDSSRP HHCCCCCCCCCCCCC | 50.54 | 26643407 | |
| 553 | Phosphorylation | RRPTAPSTPDSSRPD HCCCCCCCCCCCCCC | 30.01 | 25521595 | |
| 556 | Phosphorylation | TAPSTPDSSRPDPGV CCCCCCCCCCCCCCC | 29.47 | 26643407 | |
| 557 | Phosphorylation | APSTPDSSRPDPGVP CCCCCCCCCCCCCCC | 56.03 | 26643407 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MBRL_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MBRL_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MBRL_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of MBRL_MOUSE !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| N-linked Glycosylation | |
| Reference | PubMed |
| "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."; Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M.,Schiess R., Aebersold R., Watts J.D.; Nat. Biotechnol. 27:378-386(2009). Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-180, AND MASSSPECTROMETRY. | |
