dbPTM

MBP_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MBP_RAT
UniProt AC	P02688
Protein Name	Myelin basic protein
Gene Name	Mbp
Organism	Rattus norvegicus (Rat).
Sequence Length	195
Subcellular Localization	Myelin membrane Peripheral membrane protein Cytoplasmic side. Cytoplasmic side of myelin.
Protein Description	Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity)..
Protein Sequence	MASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFSGDRGAPKRGSGKVPWLKQSRSPLPSHARSRPGLCHMYKDSHTRTTHYGSLPQKSQRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQKPGFGYGGRASDYKSAHKGFKGAYDAQGTLSKIFKLGGRDSRSGSPMARR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASQKRPSQ ------CCCCCCCCC	22.22	4141893
3	Phosphorylation	-----MASQKRPSQR -----CCCCCCCCCC	34.63	27097102
8	Phosphorylation	MASQKRPSQRHGSKY CCCCCCCCCCCCCCE	43.83	27097102
13	Phosphorylation	RPSQRHGSKYLATAS CCCCCCCCCEEEEHH	16.41	25575281
14	Acetylation	PSQRHGSKYLATAST CCCCCCCCEEEEHHH	49.20	25786129
15	Phosphorylation	SQRHGSKYLATASTM CCCCCCCEEEEHHHH	11.85	25403869
18	Phosphorylation	HGSKYLATASTMDHA CCCCEEEEHHHHHHH	20.67	25403869
20	Phosphorylation	SKYLATASTMDHARH CCEEEEHHHHHHHHH	21.65	25403869
21	Phosphorylation	KYLATASTMDHARHG CEEEEHHHHHHHHHC	24.93	25403869
26	Citrullination	ASTMDHARHGFLPRH HHHHHHHHHCCCCCC	27.35	-
26	Citrullination	ASTMDHARHGFLPRH HHHHHHHHHCCCCCC	27.35	-
32	Citrullination	ARHGFLPRHRDTGIL HHHCCCCCCCCCCCH	39.35	-
32	Citrullination	ARHGFLPRHRDTGIL HHHCCCCCCCCCCCH	39.35	-
36	Phosphorylation	FLPRHRDTGILDSIG CCCCCCCCCCHHHHH	26.53	30411139
41	Phosphorylation	RDTGILDSIGRFFSG CCCCCHHHHHHHCCC	24.40	27097102
44	Methylation	GILDSIGRFFSGDRG CCHHHHHHHCCCCCC	27.97	-
47	Phosphorylation	DSIGRFFSGDRGAPK HHHHHHCCCCCCCCC	36.75	22673903
50	Methylation	GRFFSGDRGAPKRGS HHHCCCCCCCCCCCC	46.85	-
57 (in isoform 5)	Phosphorylation	-	39.20	25403869
57 (in isoform 4)	Phosphorylation	-	39.20	25403869
57 (in isoform 2)	Phosphorylation	-	39.20	25403869
57	Phosphorylation	RGAPKRGSGKVPWLK CCCCCCCCCCCCCHH	39.20	22817900
59 (in isoform 2)	Ubiquitination	-	46.98	-
64	Acetylation	SGKVPWLKQSRSPLP CCCCCCHHCCCCCCC	42.21	22902405
66	Phosphorylation	KVPWLKQSRSPLPSH CCCCHHCCCCCCCCH	32.89	30411139
68	Phosphorylation	PWLKQSRSPLPSHAR CCHHCCCCCCCCHHC	35.72	30411139
74 (in isoform 2)	Ubiquitination	-	18.58	-
84	Phosphorylation	RPGLCHMYKDSHTRT CCCCCEECCCCCCCC	6.49	-
85	Acetylation	PGLCHMYKDSHTRTT CCCCEECCCCCCCCC	45.22	22902405
92	Phosphorylation	KDSHTRTTHYGSLPQ CCCCCCCCCCCCCCC	15.15	-
94	Phosphorylation	SHTRTTHYGSLPQKS CCCCCCCCCCCCCHH	13.30	-
96	Phosphorylation	TRTTHYGSLPQKSQR CCCCCCCCCCCHHCC	29.70	30411139
100	Acetylation	HYGSLPQKSQRTQDE CCCCCCCHHCCCCCC	46.76	22902405
100	Ubiquitination	HYGSLPQKSQRTQDE CCCCCCCHHCCCCCC	46.76	-
101	Phosphorylation	YGSLPQKSQRTQDEN CCCCCCHHCCCCCCC	21.46	25403869
104	Phosphorylation	LPQKSQRTQDENPVV CCCHHCCCCCCCCCC	32.51	25403869
115	Ubiquitination	NPVVHFFKNIVTPRT CCCCEEECCCCCCCC	44.83	-
115	Acetylation	NPVVHFFKNIVTPRT CCCCEEECCCCCCCC	44.83	22902405
119	Phosphorylation	HFFKNIVTPRTPPPS EEECCCCCCCCCCCC	11.85	25403869
119 (in isoform 4)	Phosphorylation	-	11.85	27115346
120 (in isoform 2)	Ubiquitination	-	27.53	-
122	Phosphorylation	KNIVTPRTPPPSQGK CCCCCCCCCCCCCCC	41.15	30411139
127	Deamidation	PRTPPPSQGKGRGLS CCCCCCCCCCCCCCC	64.49	-
127	Deamidated glutamine	PRTPPPSQGKGRGLS CCCCCCCCCCCCCCC	64.49	-
129	Methylation	TPPPSQGKGRGLSLS CCCCCCCCCCCCCCC	37.49	-
131	Symmetric dimethylarginine	PPSQGKGRGLSLSRF CCCCCCCCCCCCCCE	46.49	-
131	Methylation	PPSQGKGRGLSLSRF CCCCCCCCCCCCCCE	46.49	4141893
134	Phosphorylation	QGKGRGLSLSRFSWG CCCCCCCCCCCEECC	27.42	30411139
139	Phosphorylation	GLSLSRFSWGAEGQK CCCCCCEECCCCCCC	24.40	30411139
145 (in isoform 3)	Phosphorylation	-	40.03	27115346
146	Acetylation	SWGAEGQKPGFGYGG ECCCCCCCCCCCCCC	58.95	22902405
146	Ubiquitination	SWGAEGQKPGFGYGG ECCCCCCCCCCCCCC	58.95	-
151	Phosphorylation	GQKPGFGYGGRASDY CCCCCCCCCCCHHHH	17.72	-
154	Citrullination	PGFGYGGRASDYKSA CCCCCCCCHHHHHHH	26.93	-
154	Citrullination	PGFGYGGRASDYKSA CCCCCCCCHHHHHHH	26.93	-
166	Acetylation	KSAHKGFKGAYDAQG HHHCCCCCCCCCCCC	51.83	22902405
169	Phosphorylation	HKGFKGAYDAQGTLS CCCCCCCCCCCCHHH	22.08	-
172	Deamidation	FKGAYDAQGTLSKIF CCCCCCCCCHHHHHH	42.37	-
172	Deamidated glutamine	FKGAYDAQGTLSKIF CCCCCCCCCHHHHHH	42.37	-
174	Phosphorylation	GAYDAQGTLSKIFKL CCCCCCCHHHHHHHC	18.77	30411139
176	Phosphorylation	YDAQGTLSKIFKLGG CCCCCHHHHHHHCCC	24.44	27097102
177	Acetylation	DAQGTLSKIFKLGGR CCCCHHHHHHHCCCC	56.10	22902405
180	Acetylation	GTLSKIFKLGGRDSR CHHHHHHHCCCCCCC	50.09	22902405
184	Citrullination	KIFKLGGRDSRSGSP HHHHCCCCCCCCCCC	36.61	-
184	Citrullination	KIFKLGGRDSRSGSP HHHHCCCCCCCCCCC	36.61	-
186	Phosphorylation	FKLGGRDSRSGSPMA HHCCCCCCCCCCCCC	27.30	22673903
188	Phosphorylation	LGGRDSRSGSPMARR CCCCCCCCCCCCCCC	47.80	28551015
190	Phosphorylation	GRDSRSGSPMARR-- CCCCCCCCCCCCC--	16.85	25403869
195	Citrullination	SGSPMARR------- CCCCCCCC-------	41.16	-
195	Citrullination	SGSPMARR------- CCCCCCCC-------	41.16	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
190	S	Phosphorylation	Kinase	UHMK1	Q63285	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
131	R	Methylation		-
Arg-131 was found to be 44% monomethylated and 11% symmetrically dimethylated.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MBP_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MBP_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MBP_RAT

Related Literatures of Post-Translational Modification

show