MAT1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAT1_MOUSE
• UniProt AC: P51949
• Protein Name: CDK-activating kinase assembly factor MAT1
• Gene Name: Mnat1
• Organism: Mus musculus (Mouse).
• Sequence Length: 309
• Subcellular Localization: Nucleus.
• Protein Description: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II..
• Protein Sequence: MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLENTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQEHEQRRLFIQKEEELQQALKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPRSMKPVTFSTGIKMGQQISLAPIQKLEEALYEYQPLQIETCGPQVPEQELLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MDDQGCPR -------CCCCCCCC	13.30	-
29	Phosphorylation	MVNVCGHTLCESCVD HHHHCCHHHHHHHHH	20.56	-
33	Phosphorylation	CGHTLCESCVDLLFV CCHHHHHHHHHHHHH	20.60	-
51	Phosphorylation	GNCPECGTPLRKSNF CCCCCCCCCCCCCCC	30.70	25266776
180	Ubiquitination	QALKRKNKQAFLDEL HHHHHHCHHHHHHHH	46.14	22790023
279	Phosphorylation	LNHVRAASPQDLAGG HHHHHCCCHHHHCCC	23.31	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAT1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAT1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAT1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MAT1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.