MAST1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAST1_MOUSE
• UniProt AC: Q9R1L5
• Protein Name: Microtubule-associated serine/threonine-protein kinase 1
• Gene Name: Mast1 {ECO:0000312|MGI:MGI:1861901}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1570
• Subcellular Localization: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Colocalizes with syntrophins at the cell membrane.
• Protein Description: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins..
• Protein Sequence: MSDSLWTALSNFSMPSFPGGSMFRRTKSCRTSNRKSLILTSTSPTLPRPHSPLPGHLGSSPLDSPRNFSPNTPAHFSFASSRRADGRRWSLASLPSSGYGTNTPSSTVSSSCSSQERLHQLPYQPTVDELHFLSKHFGSTESITDEDGGRRSPAVRPRSRSLSPGRSPSSYDNEIVMMNHVYKERFPKATAQMEEKLRDFARAYEPDSVLPLADGVLSFIHHQIIELARDCLTKSRDGLITTVYFYELQENLEKLLQDAYERSESLEVAFVTQLVKKLLIIISRPARLLECLEFNPEEFYHLLEAAEGHAKEGHLVKTDIPRYIIRQLGLTRDPFPDVVRLEEQDSGGSNTPEQDDTSEGRSSTSKAKKPPGESDFDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQNLILRNQIQQAFVERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGGDCATLLKNIGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMGHIKLTDFGLSKMGLMSLTTNLYEGHIEKDAREFLDKQVCGTPEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGCVPFFGDTPEELFGQVISDDILWPEGDEALPTDAQLLISSLLQTNPLVRLGAGGAFEVKQHSFFRDLDWTGLLRQKAEFIPHLESEDDTSYFDTRSDRYHHVNSYDEDDTTEEEPVEIRQFSSCSPRFSKVYSSMEQLSQHEPKTPVSASGASKRDPSAKGPEEKVAGKREGLGGLTLREKTWRGGSPEIKRFSASEASFLEGEASPPLGARRRFSALLEPSRFTAPQEDEDEARLRRPPRPSSDPPSSLDTRVPKEAVQGEGTSTPGEPEATERSHPGDLGPPSKDGDPSGPRATNDLVLRRARHQQLSGDLAVEKRPSRTGGKVIKSASATALSVMIPAVDPHGGSPLASPMSPRSLSSNPSSRDSSPSRDYSPAVSGLRSPITIQRSGKKYGFTLRAIRVYMGDSDVYSVHHIVWHVEEGGPAQEAGLCAGDLITHVNGEPVHGMVHPEVVELILKSGNKVAVTTTPFENTSIRIGPARRSSYKAKMARRNKRPSAKDGQESKKRSSLFRKITKQSNLLHTSRSLSSLNRSLSSSDSLPGSPTHGLPARSPTHSYRSTPDSAYLGASSQSSSPASSTPNSPASSASHHIRPSTLHGLSPKLHRQYRSARCKSAGNIPLSPLAHTPSPTQASPPPLPGHTVGSSHTTQSFPAKLHSSPPVVRPRPKSAEPPRSPLLKRVQSAEKLGASLGADKKGALRKHSLEVGHPDFRKDFHGELALHSLAESDGETPPIEGPGATRQVAVRRLGRQESPLSLGADPLLPDGVQRPMASSKEDSAGGTEACTPPRATTPGSRTLERDSGCTRHQSVQTEDGPGGVARALAKAALSPVQEHETGRRSSSGEAGTPPVPIVVEPARPGVKTQAPQPLGTDSKGLKEPVAQMPLMPDAPRGRERWVLEEVEERTTLSGLRSKPASPKLSPDPQTPTLVPTKNVPRSAAPSVPPASLMVPGTKPEAGLNSRCPAEAVTPAGLTKTGAPSPASLGP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	MPSFPGGSMFRRTKS CCCCCCCCCCCCCCC	22.21	-
41	Phosphorylation	RKSLILTSTSPTLPR CCEEEEEECCCCCCC	24.36	29899451
42	Phosphorylation	KSLILTSTSPTLPRP CEEEEEECCCCCCCC	33.23	28066266
43	Phosphorylation	SLILTSTSPTLPRPH EEEEEECCCCCCCCC	18.69	22817900
45	Phosphorylation	ILTSTSPTLPRPHSP EEEECCCCCCCCCCC	49.51	22817900
51	Phosphorylation	PTLPRPHSPLPGHLG CCCCCCCCCCCCCCC	30.71	29899451
59	Phosphorylation	PLPGHLGSSPLDSPR CCCCCCCCCCCCCCC	34.83	19060867
60	Phosphorylation	LPGHLGSSPLDSPRN CCCCCCCCCCCCCCC	27.90	21082442
69	Phosphorylation	LDSPRNFSPNTPAHF CCCCCCCCCCCCCCE	22.31	22324799
72	Phosphorylation	PRNFSPNTPAHFSFA CCCCCCCCCCCEECC	25.82	22324799
90	Phosphorylation	RADGRRWSLASLPSS CCCCCCEEEECCCCC	16.55	25521595
93	Phosphorylation	GRRWSLASLPSSGYG CCCEEEECCCCCCCC	46.21	29899451
96	Phosphorylation	WSLASLPSSGYGTNT EEEECCCCCCCCCCC	41.51	22807455
97	Phosphorylation	SLASLPSSGYGTNTP EEECCCCCCCCCCCC	33.81	21082442
99	Phosphorylation	ASLPSSGYGTNTPSS ECCCCCCCCCCCCCC	23.79	29899451
105	Phosphorylation	GYGTNTPSSTVSSSC CCCCCCCCCCCCCCC	36.28	29899451
106	Phosphorylation	YGTNTPSSTVSSSCS CCCCCCCCCCCCCCC	33.75	21082442
109	Phosphorylation	NTPSSTVSSSCSSQE CCCCCCCCCCCCCCH	19.34	20415495
110	Phosphorylation	TPSSTVSSSCSSQER CCCCCCCCCCCCCHH	30.90	29899451
111	Phosphorylation	PSSTVSSSCSSQERL CCCCCCCCCCCCHHH	15.54	20415495
113	Phosphorylation	STVSSSCSSQERLHQ CCCCCCCCCCHHHHC	36.68	22807455
114	Phosphorylation	TVSSSCSSQERLHQL CCCCCCCCCHHHHCC	40.15	21183079
126	Phosphorylation	HQLPYQPTVDELHFL HCCCCCCCHHHHHHH	25.68	29899451
139	Phosphorylation	FLSKHFGSTESITDE HHHHHHCCCCCEECC	28.23	25521595
140	Phosphorylation	LSKHFGSTESITDED HHHHHCCCCCEECCC	33.85	22817900
142	Phosphorylation	KHFGSTESITDEDGG HHHCCCCCEECCCCC	30.77	19060867
144	Phosphorylation	FGSTESITDEDGGRR HCCCCCEECCCCCCC	42.49	21183079
152	Phosphorylation	DEDGGRRSPAVRPRS CCCCCCCCCCCCCCC	18.82	22817900
159	Phosphorylation	SPAVRPRSRSLSPGR CCCCCCCCCCCCCCC	28.98	25159016
161	Phosphorylation	AVRPRSRSLSPGRSP CCCCCCCCCCCCCCC	34.15	27087446
163	Phosphorylation	RPRSRSLSPGRSPSS CCCCCCCCCCCCCCH	26.93	27087446
167	Phosphorylation	RSLSPGRSPSSYDNE CCCCCCCCCCHHCCC	34.74	22817900
169	Phosphorylation	LSPGRSPSSYDNEIV CCCCCCCCHHCCCEE	42.66	29899451
170	Phosphorylation	SPGRSPSSYDNEIVM CCCCCCCHHCCCEEE	39.63	29899451
171	Phosphorylation	PGRSPSSYDNEIVMM CCCCCCHHCCCEEEC	27.42	29899451
346	Phosphorylation	VRLEEQDSGGSNTPE EEEEECCCCCCCCCC	44.76	25521595
349	Phosphorylation	EEQDSGGSNTPEQDD EECCCCCCCCCCCCC	40.84	25521595
351	Phosphorylation	QDSGGSNTPEQDDTS CCCCCCCCCCCCCCC	29.87	19060867
508	Phosphorylation	KPDNLLITSMGHIKL CCCCEEEEECCCEEE	16.78	20469934
521	Phosphorylation	KLTDFGLSKMGLMSL EECCCCCHHHCHHHH	22.45	23737553
670	Phosphorylation	EFIPHLESEDDTSYF ECCCCCCCCCCCCCC	53.32	29899451
681	Phosphorylation	TSYFDTRSDRYHHVN CCCCCCCCCCCCCCC	28.65	29899451
684	Phosphorylation	FDTRSDRYHHVNSYD CCCCCCCCCCCCCCC	10.98	29899451
689	Phosphorylation	DRYHHVNSYDEDDTT CCCCCCCCCCCCCCC	32.64	21183079
690	Phosphorylation	RYHHVNSYDEDDTTE CCCCCCCCCCCCCCC	20.39	19060867
695	Phosphorylation	NSYDEDDTTEEEPVE CCCCCCCCCCCCCCC	48.72	29899451
696	Phosphorylation	SYDEDDTTEEEPVEI CCCCCCCCCCCCCCH	48.68	29899451
707	Phosphorylation	PVEIRQFSSCSPRFS CCCHHHCCCCCHHHH	23.30	28066266
708	Phosphorylation	VEIRQFSSCSPRFSK CCHHHCCCCCHHHHH	21.65	28066266
710	Phosphorylation	IRQFSSCSPRFSKVY HHHCCCCCHHHHHHH	22.51	25521595
717	Phosphorylation	SPRFSKVYSSMEQLS CHHHHHHHHHHHHHH	9.96	25177544
718	Phosphorylation	PRFSKVYSSMEQLSQ HHHHHHHHHHHHHHC	26.62	29899451
719	Phosphorylation	RFSKVYSSMEQLSQH HHHHHHHHHHHHHCC	14.51	22817900
730	Phosphorylation	LSQHEPKTPVSASGA HHCCCCCCCCCCCCC	39.37	-
738	Phosphorylation	PVSASGASKRDPSAK CCCCCCCCCCCCCCC	31.58	27841257
791	Phosphorylation	SFLEGEASPPLGARR HHHCCCCCCCCCCHH	23.81	29899451
801	Phosphorylation	LGARRRFSALLEPSR CCCHHHHHHHHCCCC	19.05	26643407
807	Phosphorylation	FSALLEPSRFTAPQE HHHHHCCCCCCCCCC	30.56	26643407
851	Phosphorylation	VQGEGTSTPGEPEAT HCCCCCCCCCCCCCC	34.84	29899451
895	Phosphorylation	RARHQQLSGDLAVEK HHHHHHHCCCEEECC	26.39	22817900
943	Phosphorylation	ASPMSPRSLSSNPSS CCCCCCCHHCCCCCC	35.67	29899451
945	Phosphorylation	PMSPRSLSSNPSSRD CCCCCHHCCCCCCCC	29.34	25521595
946	Phosphorylation	MSPRSLSSNPSSRDS CCCCHHCCCCCCCCC	59.04	22802335
949	Phosphorylation	RSLSSNPSSRDSSPS CHHCCCCCCCCCCCC	42.11	29899451
950	Phosphorylation	SLSSNPSSRDSSPSR HHCCCCCCCCCCCCC	41.17	29899451
953	Phosphorylation	SNPSSRDSSPSRDYS CCCCCCCCCCCCCCC	42.93	25521595
954	Phosphorylation	NPSSRDSSPSRDYSP CCCCCCCCCCCCCCH	31.05	25521595
956	Phosphorylation	SSRDSSPSRDYSPAV CCCCCCCCCCCCHHH	39.47	29899451
959	Phosphorylation	DSSPSRDYSPAVSGL CCCCCCCCCHHHCCC	18.55	29899451
960	Phosphorylation	SSPSRDYSPAVSGLR CCCCCCCCHHHCCCC	15.63	20415495
964	Phosphorylation	RDYSPAVSGLRSPIT CCCCHHHCCCCCCEE	33.93	20415495
968	Phosphorylation	PAVSGLRSPITIQRS HHHCCCCCCEEEEEC	26.20	25521595
971	Phosphorylation	SGLRSPITIQRSGKK CCCCCCEEEEECCCE	17.91	19060867
1091	Acetylation	AKDGQESKKRSSLFR CCCCHHHHHHHHHHH	51.99	19849359
1092	Acetylation	KDGQESKKRSSLFRK CCCHHHHHHHHHHHH	67.78	19849369
1104	Phosphorylation	FRKITKQSNLLHTSR HHHHHHHHHHHHHHC	30.88	22817900
1112	Phosphorylation	NLLHTSRSLSSLNRS HHHHHHCCHHHHHHH	32.16	22324799
1114	Phosphorylation	LHTSRSLSSLNRSLS HHHHCCHHHHHHHCC	33.74	23737553
1115	Phosphorylation	HTSRSLSSLNRSLSS HHHCCHHHHHHHCCC	34.65	28066266
1118	Dimethylation	RSLSSLNRSLSSSDS CCHHHHHHHCCCCCC	44.24	-
1118	Methylation	RSLSSLNRSLSSSDS CCHHHHHHHCCCCCC	44.24	18965231
1119	Phosphorylation	SLSSLNRSLSSSDSL CHHHHHHHCCCCCCC	31.37	24759943
1121	Phosphorylation	SSLNRSLSSSDSLPG HHHHHHCCCCCCCCC	29.10	22817900
1122	Phosphorylation	SLNRSLSSSDSLPGS HHHHHCCCCCCCCCC	43.38	29109428
1123	Phosphorylation	LNRSLSSSDSLPGSP HHHHCCCCCCCCCCC	28.04	24759943
1125	Phosphorylation	RSLSSSDSLPGSPTH HHCCCCCCCCCCCCC	38.11	24759943
1129	Phosphorylation	SSDSLPGSPTHGLPA CCCCCCCCCCCCCCC	25.37	24759943
1131	Phosphorylation	DSLPGSPTHGLPARS CCCCCCCCCCCCCCC	30.21	24759943
1137	Dimethylation	PTHGLPARSPTHSYR CCCCCCCCCCCCCCC	41.03	-
1137	Methylation	PTHGLPARSPTHSYR CCCCCCCCCCCCCCC	41.03	18965241
1138	Phosphorylation	THGLPARSPTHSYRS CCCCCCCCCCCCCCC	35.94	29899451
1140	Phosphorylation	GLPARSPTHSYRSTP CCCCCCCCCCCCCCC	25.38	-
1142	Phosphorylation	PARSPTHSYRSTPDS CCCCCCCCCCCCCCC	25.39	29899451
1186	Phosphorylation	PSTLHGLSPKLHRQY HHHHCCCCHHHHHHH	25.28	28066266
1200	Phosphorylation	YRSARCKSAGNIPLS HHHHHHHCCCCCCCC	45.06	27841257
1243	Phosphorylation	SFPAKLHSSPPVVRP CCCCCCCCCCCCCCC	55.78	28066266
1244	Phosphorylation	FPAKLHSSPPVVRPR CCCCCCCCCCCCCCC	23.60	28066266
1254	Phosphorylation	VVRPRPKSAEPPRSP CCCCCCCCCCCCCCH	40.31	24899341
1260	Phosphorylation	KSAEPPRSPLLKRVQ CCCCCCCCHHHHHHH	26.18	24899341
1268	Phosphorylation	PLLKRVQSAEKLGAS HHHHHHHHHHHHHHC	35.22	23737553
1288	Phosphorylation	KGALRKHSLEVGHPD CCHHHHHCCCCCCCC	29.30	22817900
1308	Phosphorylation	HGELALHSLAESDGE CCHHHHHHHHHCCCC	30.08	29899451
1312	Phosphorylation	ALHSLAESDGETPPI HHHHHHHCCCCCCCC	45.36	29899451
1341	Phosphorylation	GRQESPLSLGADPLL CCCCCCCCCCCCCCC	28.30	29899451
1367	Phosphorylation	KEDSAGGTEACTPPR CCCCCCCCCCCCCCC	21.35	29899451
1371	Phosphorylation	AGGTEACTPPRATTP CCCCCCCCCCCCCCC	43.29	25521595
1377	Phosphorylation	CTPPRATTPGSRTLE CCCCCCCCCCCCCEE	25.35	29899451
1394	Phosphorylation	SGCTRHQSVQTEDGP CCCCCCCCEECCCCC	15.29	29899451
1414	Phosphorylation	ALAKAALSPVQEHET HHHHHHCCCHHHCCC	20.49	22324799
1421	Phosphorylation	SPVQEHETGRRSSSG CCHHHCCCCCCCCCC	37.59	29899451
1425	Phosphorylation	EHETGRRSSSGEAGT HCCCCCCCCCCCCCC	27.74	29899451
1426	Phosphorylation	HETGRRSSSGEAGTP CCCCCCCCCCCCCCC	40.32	30372032
1427	Phosphorylation	ETGRRSSSGEAGTPP CCCCCCCCCCCCCCC	41.73	30372032
1432	Phosphorylation	SSSGEAGTPPVPIVV CCCCCCCCCCCCEEE	31.31	29899451
1491	Phosphorylation	EEVEERTTLSGLRSK HHHHHHCCCCCCCCC	25.75	22802335
1493	Phosphorylation	VEERTTLSGLRSKPA HHHHCCCCCCCCCCC	33.42	22802335
1501	Phosphorylation	GLRSKPASPKLSPDP CCCCCCCCCCCCCCC	30.97	29899451
1505	Phosphorylation	KPASPKLSPDPQTPT CCCCCCCCCCCCCCC	33.12	28066266
1510	Phosphorylation	KLSPDPQTPTLVPTK CCCCCCCCCCCCCCC	24.51	28066266
1512	Phosphorylation	SPDPQTPTLVPTKNV CCCCCCCCCCCCCCC	43.72	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1260	S	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAST1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAST1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MAST1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.