MARS_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MARS_DROME
• UniProt AC: Q7K3L1
• Protein Name: Guanylate kinase-associated protein mars
• Gene Name: mars
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 921
• Subcellular Localization: Cell membrane ; Peripheral membrane protein . Nucleus, nucleoplasm . Cytoplasm . Cytoplasm, cytoskeleton, spindle . Localizes to the cell membrane of epithelial cells. Its subcellular localization dynamically changes during cell-cycle progression. At
• Protein Description: Cell cycle regulator..
• Protein Sequence: MQRHKELYKEQSLVLSPRNHCQENRDRLQAARAKKREDCFYQNRIISVSPTPVKIKQLAAAQAALTQENVAPKLESPERLDTKPAELLKESNPKVSRQKLYLQRYMEWKIAKTKEHKQQDQKRRGAAINVPTVKQSKALPKSQTFRVPDNLASAKQKEAAPMFQPPKRCSLYMIANPTGKGKAAEPIKPSIPKPTSAAAPPSSNTVAASSALARHKSAASATKIVPAIRQNNNPVALARQKAAARPIPNTTKQTTSVRQPGIEAKKITTTIPRPTPATVTKAKTPGIRQQPPVVSTKPRLPEPPAPRTARLPNVLSKPFEKPLGNKAPVTRRANVVKPQPIRGGGGAAAKFKDTAGATSKAASHSIRMKATKIKSQYTRLQDNVRKLPQLKAELLHAATLDIPPLTPLDDIHNPFIDQATSTQCKSNNSSGHLLEAFGDTILLSPVAPVKAEGESSVKRQLLPEGKKEASGPVAKKKFDFTRYSVANSPAEDSLILDPQQTTVKEDTGDSTLVPEGTKTPPRRESNGMPNYLSPFVSVSRGKVNSRCEKEKRNSFYLSNEESPLEVRRAIESVLYFRLQLENEITRLQALCAEWEAYSKENEARLQETGGIDMINVTIGQTRLLTTKKMMQFSGLIDRCEAGATGKNSQPNDGSEDSKPVQAEDLEGWWDMLRLQSENVDKRFDNLKRWKANDWLDPDAVAEEPKQPKPKPKISRNMKIKSKAKPSSNLQQFLRKAHANMKKTKVEEPTLEDGLPATSSRHSSPRVIVVRNRRSFSPARTVLRMSTGEGRQSIAPNALLKSAILAAAEQNAAKTPPPKPRTSILKTPGTTKRQNRGVLFSAKKSVRRFQFTYEEGNISNDETVGADKLEDCEEDMSLEASTESGSLEQNPGRDSNQENEATPRTYTLRNRRVNLRPSSEFM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	KEQSLVLSPRNHCQE HHHCCCCCCCHHHHH	17.84	25749252
47	Phosphorylation	FYQNRIISVSPTPVK CCCCCEEEECCCCHH	17.73	19429919
49	Phosphorylation	QNRIISVSPTPVKIK CCCEEEECCCCHHHH	19.10	19429919
51	Phosphorylation	RIISVSPTPVKIKQL CEEEECCCCHHHHHH	32.96	19429919
76	Phosphorylation	NVAPKLESPERLDTK CCCCCCCCHHHCCCC	42.36	19429919
170	Phosphorylation	FQPPKRCSLYMIANP CCCCCCEEEEEEECC	26.94	22817900
172	Phosphorylation	PPKRCSLYMIANPTG CCCCEEEEEEECCCC	3.11	18327897
275	Phosphorylation	TTTIPRPTPATVTKA EECCCCCCCCCCCCC	27.17	22817900
280	Phosphorylation	RPTPATVTKAKTPGI CCCCCCCCCCCCCCC	22.41	22817900
426	Phosphorylation	ATSTQCKSNNSSGHL HCCCCCCCCCCCCCH	49.20	22817900
444	Phosphorylation	FGDTILLSPVAPVKA HCCEEEEECCCCCCC	17.55	22817900
519	Phosphorylation	LVPEGTKTPPRRESN CCCCCCCCCCCCHHC	38.06	18327897
525	Phosphorylation	KTPPRRESNGMPNYL CCCCCCHHCCCCCCC	36.55	21082442
554	Phosphorylation	CEKEKRNSFYLSNEE HHHHHCCCCCCCCCC	21.21	22817900
556	Phosphorylation	KEKRNSFYLSNEESP HHHCCCCCCCCCCCH	14.72	21082442
785	Phosphorylation	ARTVLRMSTGEGRQS CCEEEECCCCCCCCC	27.16	22817900
792	Phosphorylation	STGEGRQSIAPNALL CCCCCCCCCCHHHHH	21.25	22817900
814	Phosphorylation	AEQNAAKTPPPKPRT HHHHHHCCCCCCCCC	35.98	21082442
826	Phosphorylation	PRTSILKTPGTTKRQ CCCCCCCCCCCCCCC	24.41	22817900
840	Phosphorylation	QNRGVLFSAKKSVRR CCCEEEEECCCHHEE	34.71	22817900
858	Phosphorylation	TYEEGNISNDETVGA EEECCCCCCCCEECC	42.08	29892262

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MARS_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MARS_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MARS_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IMB_DROME	Fs(2)Ket	physical	25053984
PP11_DROME	Pp1alpha-96A	physical	25053984

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Phosphoproteome analysis of Drosophila melanogaster embryos.";
Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
J. Proteome Res. 7:1675-1682(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-49; THR-51; SER-170;TYR-172; SER-444; THR-519; SER-554; SER-785; SER-792 AND THR-826, ANDMASS SPECTROMETRY.
PubMed: 18327897

"An integrated chemical, mass spectrometric and computational strategyfor (quantitative) phosphoproteomics: application to Drosophilamelanogaster Kc167 cells.";
Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D.,Juenger M.A., Eng J.K., Aebersold R., Tao W.A.;
Mol. Biosyst. 3:275-286(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-76 AND SER-554, AND MASSSPECTROMETRY.
PubMed: 17372656