MARH3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MARH3_RAT
• UniProt AC: Q5XIE5
• Protein Name: E3 ubiquitin-protein ligase MARCH3
• Gene Name: 3-Mar
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 253
• Subcellular Localization: Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.
• Protein Description: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates..
• Protein Sequence: MTTSRCSHLPEVLPDCTSSAAPVVKTVEDCGSLVNGQPQYVMQVSAKDGQLLSTVVRTLATQSPFNDRPMCRICHEGSSQEDLLSPCECTGTLGTIHRSCLEHWLSSSNTSYCELCHFRFAVERKPRPLVEWLRNPGPQHEKRTLFGDMVCFLFITPLATISGWLCLRGAVDHLHFSSRLEAVGLIALTVALFTIYLFWTLVSFRYHCRLYNEWRRTNQRVILLIPKSVNIPSNQQSLLGLHSVKRNSKETIV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
112	Phosphorylation	LSSSNTSYCELCHFR HHCCCCCCCHHHCCE	6.47	-
237	Phosphorylation	NIPSNQQSLLGLHSV CCCCCCCHHHCCHHC	18.79	-
243	Phosphorylation	QSLLGLHSVKRNSKE CHHHCCHHCCCCCCC	34.08	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MARH3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MARH3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MARH3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBC_RAT	Ubc	physical	16428329

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.