MARE3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MARE3_RAT
• UniProt AC: Q5XIT1
• Protein Name: Microtubule-associated protein RP/EB family member 3
• Gene Name: Mapre3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 281
• Subcellular Localization: Cytoplasm, cytoskeleton . Associated with the microtubule network. Detected at the plus end of microtubules.
• Protein Description: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (By similarity). May play a role in cell migration (By similarity)..
• Protein Sequence: MAVNVYSTSVTSENLSRHDMLAWVNDSLHLNYTKIEQLCSGAAYCQFMDMLFPGCVHLRKVKFQAKLEHEYIHNFKVLQAAFKKMGVDKIIPVEKLVKGKFQDNFEFIQWFKKFFDANYDGKDYNPLLARQGQDVAPPPNPGDQIFNKSKKLIGTAVPQRTSPTGPKNMQTSGRLSNVAPPCILRKNPPSARNGGHEADAQILELNQQLLDLKLTVDGLEKERDFYFSKLRDIELICQEHESENSPVISGIIGILYATEEGFAPPEDDEIEEHQQEDQDEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAVNVYSTS ------CCCEEEECC	11.11	-
66	Acetylation	RKVKFQAKLEHEYIH EECEEEEECCCHHHH	43.56	-
71	Phosphorylation	QAKLEHEYIHNFKVL EEECCCHHHHHHHHH	14.91	-
76	Acetylation	HEYIHNFKVLQAAFK CHHHHHHHHHHHHHH	47.56	22902405
83	Acetylation	KVLQAAFKKMGVDKI HHHHHHHHHCCCCEE	36.80	22902405
113	Ubiquitination	EFIQWFKKFFDANYD HHHHHHHHHHCCCCC	41.61	-
113	Acetylation	EFIQWFKKFFDANYD HHHHHHHHHHCCCCC	41.61	22902405
122	Acetylation	FDANYDGKDYNPLLA HCCCCCCCCCCHHHH	54.89	22902405
124	Phosphorylation	ANYDGKDYNPLLARQ CCCCCCCCCHHHHHC	23.36	-
155	Phosphorylation	KSKKLIGTAVPQRTS CHHHCCCEECCCCCC	19.93	25575281
161	Phosphorylation	GTAVPQRTSPTGPKN CEECCCCCCCCCCCC	33.54	23298284
162	Phosphorylation	TAVPQRTSPTGPKNM EECCCCCCCCCCCCC	23.74	30411139
164	Phosphorylation	VPQRTSPTGPKNMQT CCCCCCCCCCCCCCC	66.92	25403869
171	Phosphorylation	TGPKNMQTSGRLSNV CCCCCCCCCCCCCCC	23.52	28432305
172	Phosphorylation	GPKNMQTSGRLSNVA CCCCCCCCCCCCCCC	12.67	28432305
176	Phosphorylation	MQTSGRLSNVAPPCI CCCCCCCCCCCCCEE	28.09	28432305
229	Ubiquitination	ERDFYFSKLRDIELI HHHHHHHHHHCHHHH	37.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MARE3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MARE3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MARE3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MARE3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.