dbPTM

MAP4_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MAP4_RAT
UniProt AC	Q5M7W5
Protein Name	Microtubule-associated protein 4
Gene Name	Map4
Organism	Rattus norvegicus (Rat).
Sequence Length	1057
Subcellular Localization	Cytoplasm, cytoskeleton.
Protein Description	Non-neuronal microtubule-associated protein. Promotes microtubule assembly (By similarity)..
Protein Sequence	MADLSLVDALTEPPPEIEGEIKRDFMAALEAEPYDDIVGETVEKTEFIPLLDGDEKSGNSESKRKPCVDTSQVEDIPSSKPTLLANGDHGVEGNNTTGSPTDFLVENVDYEDYQNSQSWPEDASFCFQPQQVLDTNQADPFNVHHDDGLADLLFVSSGPTNASAFIEENNPLEDSYGVLPCDSFAPTAVVSQEWSVGAPDSPHSEPCVSPEVTIETAQPATELSKAVDLESVKEQLPAKALEMMAGQTTDAVPSKESEGSPDTDAAPGPDTDVTLTKDIEESSSPDVISANVTQPFTESDMFLTQEMELLIGTEAAQVKDTMSSVEPDISSAKNTAPPTEEETVPGKDMTFPKEAETALPIEMDLAPPEDVALPKETELELAPAAGTAPLSETEVALAKDEEPSTGIPAAQEMLLSSETEVVLPSDSIMTLTKEVTVPLEAAGPLVSDMTAILETEMTLGGGTATPTETKLGKVKDMAPLPESEVALGKDVVTLPETKVTEFNNVTPLSEEEVASIKDVSPSPETETAKNADLHSGTELTLDNSMTPPSDPALPLETKVATVQIKDKETVQTQEELSEDSQLESVQLEGQSAVPPCTISPEPVKAADQKSTLPVDEGSPLEKLEQKETSGSQPPELCSGVSRQEEGKAAVGLTGNDIATPPNKELPPSPEKKAKPLATTQPAKTSTSKAKIQPTSLPKQPAPTTSGGLNKKPMSLASGSVPAAPHKRPAAATATARPSTLPARDLKPKPITETKVAEKRTSPSKPSSAPALRPGPKTTPTISKATSPSTLVSTGSSSRSPSTTLPKRPTTTKTEGKPADVKRMTAKSATADLSRSKTTSASSVKRNTTPTGATPPAGMASTRVKPMSAPCRSSVALSVDKKPTSTKPSSSAPRVSRLATTVSAPDLKSVRSKVGSTENMKHQPGGGRVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGTVKTEGGGSEAPPCPGPPAGEEPAIPEAAPDAGAPTSASGLSGHTTLSGGGDQREPQTLDSQIQETSI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADLSLVDA ------CCCCCHHHH	37.44	-
5	Phosphorylation	---MADLSLVDALTE ---CCCCCHHHHHCC	27.22	22673903
34	Phosphorylation	AALEAEPYDDIVGET HHHHCCCCCCCCCCE	20.11	22276854
60	Phosphorylation	GDEKSGNSESKRKPC CCCCCCCCCCCCCCC	46.93	-
99	Phosphorylation	EGNNTTGSPTDFLVE CCCCCCCCCCCEEEE	23.64	-
204	Phosphorylation	GAPDSPHSEPCVSPE CCCCCCCCCCCCCCC	46.77	30240740
209	Phosphorylation	PHSEPCVSPEVTIET CCCCCCCCCCEEEEE	23.27	30240740
231	Phosphorylation	SKAVDLESVKEQLPA HHCCCHHHHHHHCCH	45.87	30181290
233	Acetylation	AVDLESVKEQLPAKA CCCHHHHHHHCCHHH	49.36	22902405
248	Phosphorylation	LEMMAGQTTDAVPSK HHHHCCCCCCCCCCC	26.23	22673903
249	Phosphorylation	EMMAGQTTDAVPSKE HHHCCCCCCCCCCCC	17.67	22673903
254	Phosphorylation	QTTDAVPSKESEGSP CCCCCCCCCCCCCCC	42.32	22673903
257	Phosphorylation	DAVPSKESEGSPDTD CCCCCCCCCCCCCCC	51.50	27097102
260	Phosphorylation	PSKESEGSPDTDAAP CCCCCCCCCCCCCCC	18.62	23712012
263	Phosphorylation	ESEGSPDTDAAPGPD CCCCCCCCCCCCCCC	30.81	27097102
271	Phosphorylation	DAAPGPDTDVTLTKD CCCCCCCCCCEEECC	35.19	28551015
274	Phosphorylation	PGPDTDVTLTKDIEE CCCCCCCEEECCHHH	31.36	27097102
276	Phosphorylation	PDTDVTLTKDIEESS CCCCCEEECCHHHCC	19.80	28551015
282	Phosphorylation	LTKDIEESSSPDVIS EECCHHHCCCCCEEE	24.27	22673903
283	Phosphorylation	TKDIEESSSPDVISA ECCHHHCCCCCEEEE	49.52	22673903
284	Phosphorylation	KDIEESSSPDVISAN CCHHHCCCCCEEEEC	34.10	22668510
289	Phosphorylation	SSSPDVISANVTQPF CCCCCEEEECCCCCC	17.40	22673903
293	Phosphorylation	DVISANVTQPFTESD CEEEECCCCCCCHHH	30.27	22673903
297	Phosphorylation	ANVTQPFTESDMFLT ECCCCCCCHHHCCHH	41.06	22673903
299	Phosphorylation	VTQPFTESDMFLTQE CCCCCCHHHCCHHHH	31.17	22673903
304	Phosphorylation	TESDMFLTQEMELLI CHHHCCHHHHHHHHH	15.95	22673903
321	Phosphorylation	EAAQVKDTMSSVEPD HHHHHHHHHHHCCCC	17.15	25575281
323	Phosphorylation	AQVKDTMSSVEPDIS HHHHHHHHHCCCCHH	33.07	27097102
324	Phosphorylation	QVKDTMSSVEPDISS HHHHHHHHCCCCHHH	21.48	27097102
330	Phosphorylation	SSVEPDISSAKNTAP HHCCCCHHHCCCCCC	31.46	22108457
331	Phosphorylation	SVEPDISSAKNTAPP HCCCCHHHCCCCCCC	43.53	22108457
347	Acetylation	EEETVPGKDMTFPKE CCCCCCCCCCCCCCH	37.95	22902405
391	Phosphorylation	AAGTAPLSETEVALA CCCCCCCCHHEEECC	41.22	22673903
393	Phosphorylation	GTAPLSETEVALAKD CCCCCCHHEEECCCC	32.17	22673903
417	Phosphorylation	AQEMLLSSETEVVLP HHHHHHCCCCEEECC	48.81	-
419	Phosphorylation	EMLLSSETEVVLPSD HHHHCCCCEEECCCC	35.71	-
450	Phosphorylation	GPLVSDMTAILETEM CCCHHCHHHHEEEEE	18.61	-
497	Phosphorylation	DVVTLPETKVTEFNN CEEECCCCEEECCCC	28.95	-
500	Phosphorylation	TLPETKVTEFNNVTP ECCCCEEECCCCCCC	36.09	28689409
506	Phosphorylation	VTEFNNVTPLSEEEV EECCCCCCCCCHHHH	22.19	27097102
509	Phosphorylation	FNNVTPLSEEEVASI CCCCCCCCHHHHHCC	44.13	23712012
515	Phosphorylation	LSEEEVASIKDVSPS CCHHHHHCCCCCCCC	35.03	27097102
520	Phosphorylation	VASIKDVSPSPETET HHCCCCCCCCCCCCC	29.78	23712012
522	Phosphorylation	SIKDVSPSPETETAK CCCCCCCCCCCCCCC	28.06	23712012
525	Phosphorylation	DVSPSPETETAKNAD CCCCCCCCCCCCCCC	41.86	27097102
527	Phosphorylation	SPSPETETAKNADLH CCCCCCCCCCCCCCC	50.80	27097102
535	Phosphorylation	AKNADLHSGTELTLD CCCCCCCCCCEEEEC	55.49	25575281
537	Phosphorylation	NADLHSGTELTLDNS CCCCCCCCEEEECCC	30.73	23984901
540	Phosphorylation	LHSGTELTLDNSMTP CCCCCEEEECCCCCC	26.32	23984901
544	Phosphorylation	TELTLDNSMTPPSDP CEEEECCCCCCCCCC	24.57	27097102
546	Phosphorylation	LTLDNSMTPPSDPAL EEECCCCCCCCCCCC	31.69	27097102
549	Phosphorylation	DNSMTPPSDPALPLE CCCCCCCCCCCCCCE	58.38	23984901
599	Phosphorylation	AVPPCTISPEPVKAA CCCCCCCCCCCCCCC	12.69	25532521
610	Phosphorylation	VKAADQKSTLPVDEG CCCCCCCCCCCCCCC	29.55	28689409
611	Phosphorylation	KAADQKSTLPVDEGS CCCCCCCCCCCCCCC	41.96	25575281
618	Phosphorylation	TLPVDEGSPLEKLEQ CCCCCCCCHHHHHHH	25.02	23712012
622	Acetylation	DEGSPLEKLEQKETS CCCCHHHHHHHHCCC	66.07	22902405
628	Phosphorylation	EKLEQKETSGSQPPE HHHHHHCCCCCCCHH	45.48	27097102
629	Phosphorylation	KLEQKETSGSQPPEL HHHHHCCCCCCCHHH	37.22	27097102
631	Phosphorylation	EQKETSGSQPPELCS HHHCCCCCCCHHHHH	39.00	27097102
638	Phosphorylation	SQPPELCSGVSRQEE CCCHHHHHCCCCCCC	55.65	25575281
641	Phosphorylation	PELCSGVSRQEEGKA HHHHHCCCCCCCCCC	31.60	25575281
647	Acetylation	VSRQEEGKAAVGLTG CCCCCCCCCCCCCCC	36.13	22902405
653	Phosphorylation	GKAAVGLTGNDIATP CCCCCCCCCCCCCCC	28.19	28551015
659	Phosphorylation	LTGNDIATPPNKELP CCCCCCCCCCCCCCC	39.34	28689409
668	Phosphorylation	PNKELPPSPEKKAKP CCCCCCCCCCCCCCC	43.69	29779826
671	Acetylation	ELPPSPEKKAKPLAT CCCCCCCCCCCCCCC	62.51	22902405
685	Phosphorylation	TTQPAKTSTSKAKIQ CCCCCCCCCCCCCCC	29.94	-
694	Phosphorylation	SKAKIQPTSLPKQPA CCCCCCCCCCCCCCC	26.90	28432305
695	Phosphorylation	KAKIQPTSLPKQPAP CCCCCCCCCCCCCCC	49.73	28432305
748	Acetylation	PARDLKPKPITETKV CCCCCCCCCCCCCEE	47.68	22902405
760	Phosphorylation	TKVAEKRTSPSKPSS CEEEEECCCCCCCCC	56.93	27097102
761	Phosphorylation	KVAEKRTSPSKPSSA EEEEECCCCCCCCCC	31.07	27097102
763	Phosphorylation	AEKRTSPSKPSSAPA EEECCCCCCCCCCCC	57.89	27097102
766	Phosphorylation	RTSPSKPSSAPALRP CCCCCCCCCCCCCCC	42.75	25403869
767	Phosphorylation	TSPSKPSSAPALRPG CCCCCCCCCCCCCCC	46.96	27097102
777	Phosphorylation	ALRPGPKTTPTISKA CCCCCCCCCCCCCCC	40.93	26022182
780	Phosphorylation	PGPKTTPTISKATSP CCCCCCCCCCCCCCC	35.47	16641100
782	Phosphorylation	PKTTPTISKATSPST CCCCCCCCCCCCCCE	20.79	16641100
785	Phosphorylation	TPTISKATSPSTLVS CCCCCCCCCCCEEEE	44.93	27097102
786	Phosphorylation	PTISKATSPSTLVST CCCCCCCCCCEEEEC	23.01	23712012
788	Phosphorylation	ISKATSPSTLVSTGS CCCCCCCCEEEECCC	33.85	27097102
789	Phosphorylation	SKATSPSTLVSTGSS CCCCCCCEEEECCCC	34.27	27097102
792	Phosphorylation	TSPSTLVSTGSSSRS CCCCEEEECCCCCCC	30.11	27097102
793	Phosphorylation	SPSTLVSTGSSSRSP CCCEEEECCCCCCCC	33.34	27097102
795	Phosphorylation	STLVSTGSSSRSPST CEEEECCCCCCCCCC	25.81	27097102
796	Phosphorylation	TLVSTGSSSRSPSTT EEEECCCCCCCCCCC	30.99	27097102
797	Phosphorylation	LVSTGSSSRSPSTTL EEECCCCCCCCCCCC	38.17	27097102
799	Phosphorylation	STGSSSRSPSTTLPK ECCCCCCCCCCCCCC	25.75	23712012
801	Phosphorylation	GSSSRSPSTTLPKRP CCCCCCCCCCCCCCC	34.96	27097102
802	Phosphorylation	SSSRSPSTTLPKRPT CCCCCCCCCCCCCCC	35.42	27097102
803	Phosphorylation	SSRSPSTTLPKRPTT CCCCCCCCCCCCCCC	45.46	27097102
816	Acetylation	TTTKTEGKPADVKRM CCCCCCCCCCHHHHH	30.69	22902405
821	Acetylation	EGKPADVKRMTAKSA CCCCCHHHHHHCCHH	36.68	22902405
827	Phosphorylation	VKRMTAKSATADLSR HHHHHCCHHHHHHHC	28.52	-
839	Phosphorylation	LSRSKTTSASSVKRN HHCCCCCCCHHHCCC	31.24	28432305
841	Phosphorylation	RSKTTSASSVKRNTT CCCCCCCHHHCCCCC	35.12	28432305
842	Phosphorylation	SKTTSASSVKRNTTP CCCCCCHHHCCCCCC	31.23	28432305
847	Phosphorylation	ASSVKRNTTPTGATP CHHHCCCCCCCCCCC	37.88	27097102
848	Phosphorylation	SSVKRNTTPTGATPP HHHCCCCCCCCCCCC	23.54	28689409
850	Phosphorylation	VKRNTTPTGATPPAG HCCCCCCCCCCCCCC	37.04	27097102
853	Phosphorylation	NTTPTGATPPAGMAS CCCCCCCCCCCCCCC	31.02	23589303
860	Phosphorylation	TPPAGMASTRVKPMS CCCCCCCCCCCCCCC	14.09	27097102
861	Phosphorylation	PPAGMASTRVKPMSA CCCCCCCCCCCCCCC	29.91	28432305
872	Phosphorylation	PMSAPCRSSVALSVD CCCCCCCCEEEEECC	35.56	29779826
873	Phosphorylation	MSAPCRSSVALSVDK CCCCCCCEEEEECCC	7.64	28432305
877	Phosphorylation	CRSSVALSVDKKPTS CCCEEEEECCCCCCC	20.66	30181290
886	Ubiquitination	DKKPTSTKPSSSAPR CCCCCCCCCCCCCCC	42.54	-
899	Phosphorylation	PRVSRLATTVSAPDL CCHHHEEEECCCCCH	32.11	16641100
900	Phosphorylation	RVSRLATTVSAPDLK CHHHEEEECCCCCHH	13.57	22108457
902	Phosphorylation	SRLATTVSAPDLKSV HHEEEECCCCCHHHH	31.80	28689409
907	Acetylation	TVSAPDLKSVRSKVG ECCCCCHHHHHHHCC	55.04	22902405
907	Ubiquitination	TVSAPDLKSVRSKVG ECCCCCHHHHHHHCC	55.04	-
911	Phosphorylation	PDLKSVRSKVGSTEN CCHHHHHHHCCCCCC	29.54	25575281
915	Phosphorylation	SVRSKVGSTENMKHQ HHHHHCCCCCCCCCC	35.22	29779826
916	Phosphorylation	VRSKVGSTENMKHQP HHHHCCCCCCCCCCC	26.00	22108457
933	Acetylation	GRVQIQNKKVDISKV CCEEEECCEEEHHHH	37.49	22902405
939	Acetylation	NKKVDISKVSSKCGS CCEEEHHHHHHHCCC	46.61	22902405
960	Acetylation	KPGGGDVKIESQKLN CCCCCCCCEEEEECC	45.56	22902405
969	Acetylation	ESQKLNFKEKAQAKV EEEECCHHHHHHHHC	58.18	22902405
978	Phosphorylation	KAQAKVGSLDNVGHL HHHHHCCCCCCCCCC	35.22	23712012
990	Phosphorylation	GHLPAGGTVKTEGGG CCCCCCCEEECCCCC	20.22	28689409
1050	Phosphorylation	REPQTLDSQIQETSI CCCCCHHHHHHHCCC	32.09	-
1055	Phosphorylation	LDSQIQETSI----- HHHHHHHCCC-----	18.49	27097102
1056	Phosphorylation	DSQIQETSI------ HHHHHHCCC------	26.08	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
915	S	Phosphorylation	Kinase	MARK1	O08678	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
761	S	Phosphorylation		9108484
Phosphorylation on Ser-761 negatively regulates MAP4 activity to promote microtubule assembly.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MAP4_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of MAP4_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MAP4_RAT

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomics of vasopressin-sensitive renal cells:regulation of aquaporin-2 phosphorylation at two sites."; Hoffert J.D., Pisitkun T., Wang G., Shen R.-F., Knepper M.A.; Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-899 AND SER-902, ANDMASS SPECTROMETRY.	16641100 [Abstract]

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