MAON_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAON_HUMAN
• UniProt AC: Q16798
• Protein Name: NADP-dependent malic enzyme, mitochondrial
• Gene Name: ME3
• Organism: Homo sapiens (Human).
• Sequence Length: 604
• Subcellular Localization: Mitochondrion matrix.
• Protein Sequence: MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MGAALGTGTRLAPW -CCCCCCCCCCCCCC	35.91	24719451
9	Phosphorylation	GAALGTGTRLAPWPG CCCCCCCCCCCCCCC	23.50	24719451
107	Phosphorylation	QQSDLDKYIILMTLQ HHCCHHHEEEEEEEC	7.89	-
112	Phosphorylation	DKYIILMTLQDRNEK HHEEEEEEECCCCCH	20.16	-
119	Acetylation	TLQDRNEKLFYRVLT EECCCCCHHHHHHHH	47.66	7214695
119	Ubiquitination	TLQDRNEKLFYRVLT EECCCCCHHHHHHHH	47.66	-
137	Phosphorylation	EKFMPIVYTPTVGLA HHHCCCEECCCCCCC	14.02	25072903
138	Phosphorylation	KFMPIVYTPTVGLAC HHCCCEECCCCCCCH	11.11	25072903
140	Phosphorylation	MPIVYTPTVGLACQH CCCEECCCCCCCHHH	21.29	25072903
148	Phosphorylation	VGLACQHYGLTFRRP CCCCHHHCCCEEECC	6.48	25072903
151	Phosphorylation	ACQHYGLTFRRPRGL CHHHCCCEEECCCEE	15.67	25072903
371	Phosphorylation	RKIWMVDSKGLIVKG CEEEEECCCCEEEEC	19.74	23532336
377	2-Hydroxyisobutyrylation	DSKGLIVKGRSHLNH CCCCEEEECCCCCCH	41.43	-
467	Phosphorylation	EGRGIFASGSPFKSV CCCCEECCCCCCCEE	29.11	22199227
469	Phosphorylation	RGIFASGSPFKSVTL CCEECCCCCCCEEEE	25.35	28674419
540	Phosphorylation	RLYPPLSTIRDVSLR CCCCCHHHHHHHHHH	27.93	-
545	Phosphorylation	LSTIRDVSLRIAIKV HHHHHHHHHHHHHHH	19.07	28122231
555	Phosphorylation	IAIKVLDYAYKHNLA HHHHHHHHHHHCCHH	13.99	-
581	Phosphorylation	FVRSLVYTPDYDSFT HHHHHEECCCCCCCE	11.38	-
588	Phosphorylation	TPDYDSFTLDSYTWP CCCCCCCEECCCCCC	33.34	24719451
591	Phosphorylation	YDSFTLDSYTWPKEA CCCCEECCCCCCHHH	27.81	-
592	Phosphorylation	DSFTLDSYTWPKEAM CCCEECCCCCCHHHC	16.70	24719451
593	Phosphorylation	SFTLDSYTWPKEAMN CCEECCCCCCHHHCC	38.96	-
603	Phosphorylation	KEAMNVQTV------ HHHCCCCCC------	24.73	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAON_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAON_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAON_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of MAON_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.