MANF_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MANF_RAT
• UniProt AC: P0C5H9
• Protein Name: Mesencephalic astrocyte-derived neurotrophic factor
• Gene Name: Manf
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 179
• Subcellular Localization: Secreted . Endoplasmic reticulum lumen . Sarcoplasmic reticulum lumen . Retained in the endoplasmic reticulum (ER), and sarcoplasmic reticulum (SR) under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia.
• Protein Description: Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain (By similarity). Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. [PubMed: 16462600 Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons]
• Protein Sequence: MWATRGLAVALALSVLPDSRALRPGDCEVCISYLGRFYQDLKDRDVTFSPATIEEELIKFCREARGKENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELKYDKQIDLSTVDLKKLRVKELKKILDDWGEMCKGCAEKSDYIRKINELMPKYAPKAASARTDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Acetylation	GRFYQDLKDRDVTFS HHHHHHHHHCCCCCC	60.03	22902405
73	Phosphorylation	GKENRLCYYIGATDD CCCCCEEEEEECCCH	11.60	-
91	Acetylation	KIINEVSKPLAHHIP HHHHHHCHHHHHCCC	49.58	22902405
109	Succinylation	ICEKLKKKDSQICEL HHHHHCCCCCCCHHH	62.11	26843850
117	Acetylation	DSQICELKYDKQIDL CCCCHHHHCCCCCCC	29.16	22902405
120	Acetylation	ICELKYDKQIDLSTV CHHHHCCCCCCCCCC	46.17	22902405
130	Acetylation	DLSTVDLKKLRVKEL CCCCCCHHHHCHHHH	45.35	22902405
167	Acetylation	KINELMPKYAPKAAS HHHHHCHHHCCHHHH	39.83	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MANF_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MANF_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MANF_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MANF_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.