MAG_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAG_RAT
• UniProt AC: P07722
• Protein Name: Myelin-associated glycoprotein
• Gene Name: Mag
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 626
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Membrane raft .
• Protein Description: Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. [PubMed: 8995428]
• Protein Sequence: MIFLTTLPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIINTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAESLYLDLEEVTPAEDGIYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTLRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPHVLYSPEFRISGAPDKYESEKRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
75	Acetylation	NYPPVVFKSRTQVVH CCCCEEEECCCCEEE	27.67	22902405
99	N-linked_Glycosylation	LGDLGLRNCTLLLST HHHHHHHCCEEEEEC	28.33	-
223	N-linked_Glycosylation	GCQAAFPNTTLQFEG ECEEECCCCEEEEEE	38.96	-
246	N-linked_Glycosylation	PPVIVEMNSSVEAIE CCEEEEECCCEEEEC	20.02	-
315	N-linked_Glycosylation	ENAYGQDNRTVELSV ECCCCCCCCEEEEEE	33.37	-
332	N-linked_Glycosylation	APWKPTVNGTVVAVE CCCCCEECCEEEEEC	42.78	-
406	N-linked_Glycosylation	GQRATAFNLSVEFAP CCEEEEEEEEEECHH	29.01	-
450	N-linked_Glycosylation	AFELPSRNVTVNETE EEECCCCCEECCHHH	37.84	-
454	N-linked_Glycosylation	PSRNVTVNETEREFV CCCCEECCHHHHHHE	40.90	-
531	S-palmitoylation	AILIAIVCYITQTRR HHHHHHHHHHHHHCC	1.34	1703542
540 (in isoform 2)	Ubiquitination	-	55.64	-
543	Phosphorylation	TRRKKNVTESPSFSA HCCCCCCCCCCCCCC	39.89	30411139
545	Phosphorylation	RKKNVTESPSFSAGD CCCCCCCCCCCCCCC	19.24	27097102
547	Phosphorylation	KNVTESPSFSAGDNP CCCCCCCCCCCCCCC	40.90	27097102
549	Phosphorylation	VTESPSFSAGDNPHV CCCCCCCCCCCCCCE	35.36	2438699
558	Phosphorylation	GDNPHVLYSPEFRIS CCCCCEEECCCEEEC	22.53	27097102
565 (in isoform 2)	Phosphorylation	-	25.33	25403869
565	Phosphorylation	YSPEFRISGAPDKYE ECCCEEECCCCCHHH	25.33	25403869
570	Ubiquitination	RISGAPDKYESEKRL EECCCCCHHHHHHHH	50.27	-
570 (in isoform 2)	Ubiquitination	-	50.27	-
570 (in isoform 2)	Acetylation	-	50.27	-
570	Acetylation	RISGAPDKYESEKRL EECCCCCHHHHHHHH	50.27	22902405
575	Ubiquitination	PDKYESEKRLGSERR CCHHHHHHHHCCCHH	63.30	-
620	Phosphorylation	LTEELAEYAEIRVK- CHHHHHHHHHHEEC-	12.15	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAG_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAG_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAG_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MAG_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Palmitoylation

"The myelin-associated glycoproteins: membrane disposition, evidenceof a novel disulfide linkage between immunoglobulin-like domains, andposttranslational palmitylation.";
Pedraza L., Owens G.C., Green L.A.D., Salzer J.L.;
J. Cell Biol. 111:2651-2661(1990).
Cited for: DISULFIDE BONDS, PALMITOYLATION AT CYS-531, AND PARTIAL PROTEINSEQUENCE.
PubMed: 1703542