MAG_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAG_MOUSE
• UniProt AC: P20917
• Protein Name: Myelin-associated glycoprotein
• Gene Name: Mag
• Organism: Mus musculus (Mouse).
• Sequence Length: 626
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Membrane raft .
• Protein Description: Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. [PubMed: 7533044]
• Protein Sequence: MIFLATLPLFWIMISASRGGHWGAWMPSTISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIVNTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAKSLYLDLEEVTPGEDGVYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTIRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESSSFSGGDNPHVLYSPEFRISGAPDKYESEKRLGSERRLLGLRGESPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
22	C-linked_Glycosylation	SASRGGHWGAWMPST HCCCCCCCCCCCCCC	11.06	27922006
99	N-linked_Glycosylation	LGDLGLRNCTLLLST HHHHHHHCCEEEEEC	28.33	27922006
223	N-linked_Glycosylation	GCQAAFPNTTLQFEG ECEEECCCCEEEEEE	38.96	27922006
246	N-linked_Glycosylation	PPVIVEMNSSVEAIE CCEEEEECCCEEEEC	20.02	27922006
315	N-linked_Glycosylation	ENAYGQDNRTVELSV ECCCCCCCCEEEEEE	33.37	27922006
332	N-linked_Glycosylation	APWKPTVNGTVVAVE CCCCCEECCEEEEEC	42.78	27922006
406	N-linked_Glycosylation	GQRATAFNLSVEFAP CCEEEEEEEEEECHH	29.01	27922006
450	N-linked_Glycosylation	AFELPSRNVTVNETE EEECCCCCEECCHHH	37.84	27922006
454	N-linked_Glycosylation	PSRNVTVNETEREFV CCCCEECCHHHHHHE	40.90	27922006
475	Phosphorylation	LLLTSILTIRGQAQA EEEEEHHHHCCCCCC	13.63	27600695
531	S-palmitoylation	AILIAIVCYITQTRR HHHHHHHHHHHCCCC	1.34	-
539	Ubiquitination	YITQTRRKKNVTESS HHHCCCCCCCCCCCC	45.46	-
540	Ubiquitination	ITQTRRKKNVTESSS HHCCCCCCCCCCCCC	55.64	-
543	Phosphorylation	TRRKKNVTESSSFSG CCCCCCCCCCCCCCC	39.27	25521595
545	Phosphorylation	RKKNVTESSSFSGGD CCCCCCCCCCCCCCC	23.16	24925903
546	Phosphorylation	KKNVTESSSFSGGDN CCCCCCCCCCCCCCC	29.21	25521595
547	Phosphorylation	KNVTESSSFSGGDNP CCCCCCCCCCCCCCC	32.48	25521595
547 (in isoform 2)	Phosphorylation	-	32.48	29899451
549	Phosphorylation	VTESSSFSGGDNPHV CCCCCCCCCCCCCCE	43.76	25521595
558	Phosphorylation	GDNPHVLYSPEFRIS CCCCCEEECCCEEEC	22.53	22324799
559	Phosphorylation	DNPHVLYSPEFRISG CCCCEEECCCEEECC	17.50	22324799
565 (in isoform 2)	Phosphorylation	-	25.33	21183079
565	Phosphorylation	YSPEFRISGAPDKYE ECCCEEECCCCCHHH	25.33	29899451
570 (in isoform 2)	Ubiquitination	-	50.27	-
570	Ubiquitination	RISGAPDKYESEKRL EECCCCCHHHHHHHH	50.27	-
571 (in isoform 2)	Phosphorylation	-	31.87	29899451
573	Phosphorylation	GAPDKYESEKRLGSE CCCCHHHHHHHHCCH	45.38	29899451
580	Phosphorylation	SEKRLGSERRLLGLR HHHHHCCHHHHHHCC	39.77	29899451
590	Phosphorylation	LLGLRGESPELDLSY HHHCCCCCCCCCCCC	26.88	25521595
591	Phosphorylation	LGLRGESPELDLSYS HHCCCCCCCCCCCCC	41.70	21183079
596	Phosphorylation	ESPELDLSYSHSDLG CCCCCCCCCCCCCCC	25.02	29899451
597	Phosphorylation	SPELDLSYSHSDLGK CCCCCCCCCCCCCCC	20.07	20415495
598	Phosphorylation	PELDLSYSHSDLGKR CCCCCCCCCCCCCCC	17.09	25521595
600	Phosphorylation	LDLSYSHSDLGKRPT CCCCCCCCCCCCCCC	28.70	20415495
604	Ubiquitination	YSHSDLGKRPTKDSY CCCCCCCCCCCCCCC	63.60	-
607	Phosphorylation	SDLGKRPTKDSYTLT CCCCCCCCCCCCCCH	52.06	21183079
608	Ubiquitination	DLGKRPTKDSYTLTE CCCCCCCCCCCCCHH	47.57	-
610	Phosphorylation	GKRPTKDSYTLTEEL CCCCCCCCCCCHHHH	22.90	25521595
611	Phosphorylation	KRPTKDSYTLTEELA CCCCCCCCCCHHHHH	18.86	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAG_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAG_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAG_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MAG_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.