MAGI3_RAT - dbPTM
MAGI3_RAT - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MAGI3_RAT
UniProt AC Q9JK71
Protein Name Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3
Gene Name Magi3
Organism Rattus norvegicus (Rat).
Sequence Length 1470
Subcellular Localization Cell membrane
Peripheral membrane protein. Cell junction, tight junction. Nucleus. Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions.
Protein Description Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2..
Protein Sequence MSKTLKKKKHWLSKVQECAVSWAGPPGDLGAEIRGGAERGEFPYLGRLRDEPGGGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLITIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDTESQRKRTTSVSKMERMDSSLPEEEEDEDKEAVNGSGSMETREMHSESSDCWMKTVPSYNQTNRSMDFRNYMMRDENLEPLPKNWEMAYTDTGTIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQIGQAETHSAKTDVERAHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKMAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYALPDDSEDPVVDIVAATPVINGQSLAKGEACMSTQDFKLGAMVLDQNGKSGKLLSSDRLNGPSDSNEQRASLASSGSSQPELVTIPLVKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPCSPTKTAKMKTDTKETSGSLETINEPTPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDESPQAFSQSGSPRLNRTELPTRSAPQESYDVILQRKENEGFGFVILTSKSKPPPGVIPHKIGRVIDGSPADRCGRLKVGDHISAVNGQSIVDLSHDNIVQLIKDAGVTVTLTVVAEEEHHGPPSGTNSARQSPALQHRPMGQAQATHIPGDRTALEGEVGKDVCSSYRHSWSDHKHLAQPDTAVISVVGSRHSQSLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDIYSPSSSNVIYDEQPPPLPSSHSAATFEESHVPVTEDSLIRVQTCEKAEELKDTVQEKKSTLNGSQPEMKYQSIQKNVSKKDPSRSHGHGDKNLLKGENGVTRRGRSASPKKSVNRHSEEHLEKIPRPLRSDPKGKSRDRSLSPRKGENKGQVTIKAGSGQDPCRKDRGRSSSPRKQQKIGGNSLSNTEGKLSEAGSRRAAGLSSDSPEQLPEGKEKSGVSRKDLKLSQLGKNRTRSPEKRSSKVDEASLPSKKTSDTASRVVSEKEKGRKPGTGERSRDKTGESVQTSAKPLTQEAGEKMALSKASEVTDRGKERAGGAPESSSPVKKAPITPGPWRVPRANKVTGTAGMADKQL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
89PhosphorylationSGLTNRDTLAVIRHF
CCCCCHHHHHHHHHC		17.2429779826
141PhosphorylationQVIRDNLYLITIPCT
HHHHCCEEEEEEECC		11.43-
236PhosphorylationSKMERMDSSLPEEEE
HHHHHHHCCCCCCCC		25.1628689409
237PhosphorylationKMERMDSSLPEEEED
HHHHHHCCCCCCCCH		43.6122108457
272PhosphorylationSSDCWMKTVPSYNQT
CCCCCCCCCCCCCCC		22.8830181290
275PhosphorylationCWMKTVPSYNQTNRS
CCCCCCCCCCCCCCC		32.1730181290
279PhosphorylationTVPSYNQTNRSMDFR
CCCCCCCCCCCHHHH		29.0330181290
356PhosphorylationEKIEDPQYGTYYVDH
EECCCCCCCEEEEEC		19.4721940666
568PhosphorylationDSNEQRASLASSGSS
CCHHHHHHHHCCCCC		27.0228432305
571PhosphorylationEQRASLASSGSSQPE
HHHHHHHCCCCCCCE		40.2928432305
572PhosphorylationQRASLASSGSSQPEL
HHHHHHCCCCCCCEE		36.7728432305
574PhosphorylationASLASSGSSQPELVT
HHHHCCCCCCCEEEE		27.9622108457
575PhosphorylationSLASSGSSQPELVTI
HHHCCCCCCCEEEEE		53.9623984901
598PhosphorylationFGFAIADSPTGQKVK
CCEEEECCCCCCEEE		18.4930181290
600PhosphorylationFAIADSPTGQKVKMI
EEEECCCCCCEEEEE		57.0830181290
662PhosphorylationILRGGPCSPTKTAKM
EECCCCCCCCCCCCC		38.4428432305
664PhosphorylationRGGPCSPTKTAKMKT
CCCCCCCCCCCCCCC		25.4128432305
671PhosphorylationTKTAKMKTDTKETSG
CCCCCCCCCCCCCCC		45.4625575281
673PhosphorylationTAKMKTDTKETSGSL
CCCCCCCCCCCCCCC		35.6925575281
676PhosphorylationMKTDTKETSGSLETI
CCCCCCCCCCCCCCC		39.6922673903
677PhosphorylationKTDTKETSGSLETIN
CCCCCCCCCCCCCCC		27.7222668510
679PhosphorylationDTKETSGSLETINEP
CCCCCCCCCCCCCCC		23.8521630457
682PhosphorylationETSGSLETINEPTPQ
CCCCCCCCCCCCCCC		34.1022673903
687PhosphorylationLETINEPTPQPMPFP
CCCCCCCCCCCCCCC		28.5125575281
700PhosphorylationFPPSIIRSGSPKLDP
CCHHHHCCCCCCCCH		32.9621738781
702PhosphorylationPSIIRSGSPKLDPSE
HHHHCCCCCCCCHHH		21.8029779826
708PhosphorylationGSPKLDPSEVYLKSK
CCCCCCHHHEEEEEC		39.0828689409
737PhosphorylationVFLRKQESGFGFRVL
EEEECCCCCCCEEEC		36.6125403869
815PhosphorylationTVRRKIFYGEKQPED
EEEEEHHCCCCCCCC		28.0428689409
824PhosphorylationEKQPEDESPQAFSQS
CCCCCCCCCCHHHCC		34.3328551015
829PhosphorylationDESPQAFSQSGSPRL
CCCCCHHHCCCCCCC		26.8417683130
831PhosphorylationSPQAFSQSGSPRLNR
CCCHHHCCCCCCCCC		39.7928689409
833PhosphorylationQAFSQSGSPRLNRTE
CHHHCCCCCCCCCCC		16.4623712012
916PhosphorylationGQSIVDLSHDNIVQL
CCEEEECCCCCHHHH		25.08-
954PhosphorylationGTNSARQSPALQHRP
CCCCCCCCCCCCCCC		13.4428432305
968PhosphorylationPMGQAQATHIPGDRT
CCCCCCCCCCCCCCC		14.3028432305
987PhosphorylationEVGKDVCSSYRHSWS
CCCHHHHHHCCCCCC		30.1925575281
988PhosphorylationVGKDVCSSYRHSWSD
CCHHHHHHCCCCCCC		22.5125575281
989PhosphorylationGKDVCSSYRHSWSDH
CHHHHHHCCCCCCCC		8.9625575281
992PhosphorylationVCSSYRHSWSDHKHL
HHHHCCCCCCCCCHH		21.1925575281
994PhosphorylationSSYRHSWSDHKHLAQ
HHCCCCCCCCCHHCC		32.6225575281
1004PhosphorylationKHLAQPDTAVISVVG
CHHCCCCCEEEEEEC		29.5225575281
1008PhosphorylationQPDTAVISVVGSRHS
CCCCEEEEEECCCCC		12.2625575281
1012PhosphorylationAVISVVGSRHSQSLG
EEEEEECCCCCCCCC		18.4025575281
1015PhosphorylationSVVGSRHSQSLGCYP
EEECCCCCCCCCEEE		21.9821738781
1017PhosphorylationVGSRHSQSLGCYPVE
ECCCCCCCCCEEEEE		29.7322108457
1021PhosphorylationHSQSLGCYPVELERG
CCCCCCEEEEEECCC		14.4425575281
1035PhosphorylationGPRGFGFSLRGGKEY
CCCCCCEECCCCCEE		19.9622673903
1198PhosphorylationNVSKKDPSRSHGHGD
CCCCCCCCCCCCCCC		57.4526437020
1200PhosphorylationSKKDPSRSHGHGDKN
CCCCCCCCCCCCCCC		37.8526437020
1227PhosphorylationRSASPKKSVNRHSEE
CCCCCCCCCCCCCHH		30.6525575281
1232PhosphorylationKKSVNRHSEEHLEKI
CCCCCCCCHHHHHHC		41.2528432305
1255PhosphorylationKGKSRDRSLSPRKGE
CCCCCCCCCCCCCCC		37.1729779826
1257PhosphorylationKSRDRSLSPRKGENK
CCCCCCCCCCCCCCC		24.7316396499
1318PhosphorylationSRRAAGLSSDSPEQL
HHHCCCCCCCCHHHC		31.0527097102
1319PhosphorylationRRAAGLSSDSPEQLP
HHCCCCCCCCHHHCC		47.3427097102
1321PhosphorylationAAGLSSDSPEQLPEG
CCCCCCCCHHHCCCC		32.0821738781
1437PhosphorylationRAGGAPESSSPVKKA
CCCCCCCCCCCCCCC		34.7523984901
1438PhosphorylationAGGAPESSSPVKKAP
CCCCCCCCCCCCCCC		36.6822108457
1439PhosphorylationGGAPESSSPVKKAPI
CCCCCCCCCCCCCCC		42.8826437020
1447PhosphorylationPVKKAPITPGPWRVP
CCCCCCCCCCCCCCC		22.5728432305
1460PhosphorylationVPRANKVTGTAGMAD
CCCCCCCCCCCCCCC		30.3528689409
1462PhosphorylationRANKVTGTAGMADKQ
CCCCCCCCCCCCCCC		15.6328689409
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MAGI3_RAT !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MAGI3_RAT !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MAGI3_RAT !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MAGI3_RAT !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MAGI3_RAT

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Related Literatures of Post-Translational Modification

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