MAGI1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGI1_RAT
• UniProt AC: Q4L1J4
• Protein Name: Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1
• Gene Name: Magi1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1255
• Subcellular Localization: Cell junction, tight junction. Cytoplasm. Membrane ; Peripheral membrane protein . Localizes to epithelial cells tight junctions..
• Protein Description: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface..
• Protein Sequence: MSKVIQKKNHWTGRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAAEAAGLPGGGEGPKLAEGELLLEVQGVRVSGLPRYDVLGVIDSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGVDYSFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHTENEEEEDVPEMNSSFTADSGDQDEPTLQEATLPPVNSSALAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNAKTTSWLDPRCLNKQQKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGVYYVDHINRKTQYENPVLEAKRKRQLEQQQQQQQHQQQPQQPQPPQPEEWTEDHASVVPPVAPSHPPSNPEPAREAPLQGKPFFTRNPSELEGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVSNMKDARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKRNVQALTHNQVVDMLIECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSLRSLHTASPSHSAQVLPEYPPADVPAPDQTDSSGQKKPDPFKIWAQSRSMYEDRPMSPSPASGLSKGERDREINSTNFGECQIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFTVPKAENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSAVLQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHAPSQQGTQETRTTTKPKPDSQFEFKGPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLRRGDGSVPEYGGSNYENIPSFPGMTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
357	Phosphorylation	VHTEELDSELELPAG CCHHHCCCCEECCCC	57.62	-
373	Phosphorylation	EKIEDPVYGVYYVDH EECCCCCEEEEEEEC	13.28	21940666
587	Phosphorylation	IIVNGQETYDSPASH EEECCEEECCCCCCC	25.41	30181290
590	Phosphorylation	NGQETYDSPASHSSK CCEEECCCCCCCCCC	16.38	30181290
593	Phosphorylation	ETYDSPASHSSKTGK EECCCCCCCCCCCCC	27.56	30181290
610	Phosphorylation	NMKDARPSSPADVAS CCCCCCCCCHHHHHC	43.32	23984901
611	Phosphorylation	MKDARPSSPADVASN CCCCCCCCHHHHHCC	27.13	23984901
617	Phosphorylation	SSPADVASNSSHGYP CCHHHHHCCCCCCCC	36.77	23984901
619	Phosphorylation	PADVASNSSHGYPND HHHHHCCCCCCCCCC	22.63	23984901
620	Phosphorylation	ADVASNSSHGYPNDT HHHHCCCCCCCCCCC	25.78	23984901
623	Phosphorylation	ASNSSHGYPNDTVSL HCCCCCCCCCCCCCH	8.08	23984901
627	Phosphorylation	SHGYPNDTVSLASSI CCCCCCCCCCHHHHH	20.73	23984901
629	Phosphorylation	GYPNDTVSLASSIAT CCCCCCCCHHHHHHC	21.95	23984901
729	Phosphorylation	GLPVPKKSPKSQPLE CCCCCCCCCCCCCCC	43.62	23984901
740	Phosphorylation	QPLERKDSQNSSQHS CCCCCCCCCCCCCCC	34.01	27097102
743	Phosphorylation	ERKDSQNSSQHSVSS CCCCCCCCCCCCHHH	24.60	27097102
744	Phosphorylation	RKDSQNSSQHSVSSL CCCCCCCCCCCHHHH	39.19	27097102
747	Phosphorylation	SQNSSQHSVSSLRSL CCCCCCCCHHHHHHH	18.96	27097102
749	Phosphorylation	NSSQHSVSSLRSLHT CCCCCCHHHHHHHHC	27.03	27097102
750	Phosphorylation	SSQHSVSSLRSLHTA CCCCCHHHHHHHHCC	26.16	27097102
753	Phosphorylation	HSVSSLRSLHTASPS CCHHHHHHHHCCCCC	29.78	27097102
756	Phosphorylation	SSLRSLHTASPSHSA HHHHHHHCCCCCCCC	33.84	27097102
758	Phosphorylation	LRSLHTASPSHSAQV HHHHHCCCCCCCCCC	28.26	27097102
760	Phosphorylation	SLHTASPSHSAQVLP HHHCCCCCCCCCCCC	27.81	27097102
762	Phosphorylation	HTASPSHSAQVLPEY HCCCCCCCCCCCCCC	25.41	28689409
769	Phosphorylation	SAQVLPEYPPADVPA CCCCCCCCCCCCCCC	16.75	27097102
799	Phosphorylation	KIWAQSRSMYEDRPM HHEECCCCCCCCCCC	30.85	25575281
801	Phosphorylation	WAQSRSMYEDRPMSP EECCCCCCCCCCCCC	18.87	25575281
807	Phosphorylation	MYEDRPMSPSPASGL CCCCCCCCCCCCCCC	25.55	25575281
809	Phosphorylation	EDRPMSPSPASGLSK CCCCCCCCCCCCCCC	26.28	25575281
812	Phosphorylation	PMSPSPASGLSKGER CCCCCCCCCCCCCCC	43.58	25575281
815	Phosphorylation	PSPASGLSKGERDRE CCCCCCCCCCCCCCC	41.98	25575281
937	Phosphorylation	KAENEVPSPASSHHS CCCCCCCCCCCCCCC	37.97	27097102
940	Phosphorylation	NEVPSPASSHHSSNQ CCCCCCCCCCCCCCC	33.32	27097102
941	Phosphorylation	EVPSPASSHHSSNQP CCCCCCCCCCCCCCC	27.59	27097102
944	Phosphorylation	SPASSHHSSNQPASL CCCCCCCCCCCCCCC	26.09	27097102
945	Phosphorylation	PASSHHSSNQPASLT CCCCCCCCCCCCCCC	34.82	27097102
950	Phosphorylation	HSSNQPASLTEEKRT CCCCCCCCCCCCCCC	42.37	27097102
952	Phosphorylation	SNQPASLTEEKRTPQ CCCCCCCCCCCCCCC	39.33	27097102
957	Phosphorylation	SLTEEKRTPQGSQNS CCCCCCCCCCCCCCC	30.91	27097102
961	Phosphorylation	EKRTPQGSQNSLNTV CCCCCCCCCCCCCEE	22.42	27097102
964	Phosphorylation	TPQGSQNSLNTVSSG CCCCCCCCCCEECCC	18.50	27097102
967	Phosphorylation	GSQNSLNTVSSGSGS CCCCCCCEECCCCCC	27.36	27097102
969	Phosphorylation	QNSLNTVSSGSGSTS CCCCCEECCCCCCCC	27.26	27097102
970	Phosphorylation	NSLNTVSSGSGSTSG CCCCEECCCCCCCCC	32.42	27097102
972	Phosphorylation	LNTVSSGSGSTSGIG CCEECCCCCCCCCCC	31.36	27097102
974	Phosphorylation	TVSSGSGSTSGIGSG EECCCCCCCCCCCCC	22.54	27097102
975	Phosphorylation	VSSGSGSTSGIGSGG ECCCCCCCCCCCCCC	34.20	27097102
976	Phosphorylation	SSGSGSTSGIGSGGG CCCCCCCCCCCCCCC	30.06	27097102
980	Phosphorylation	GSTSGIGSGGGGGSG CCCCCCCCCCCCCCC	32.13	27097102
986	Phosphorylation	GSGGGGGSGVVSAVL CCCCCCCCCHHEEEE	31.52	27097102
990	Phosphorylation	GGGSGVVSAVLQPYD CCCCCHHEEEECCCE	15.39	27097102
1070	Phosphorylation	GCSITNKSHSDIVNL CEECCCCCHHHHHHH	30.23	-
1159	Acetylation	VELERGAKGFGFSLR EEEECCCCCCCEEEC	58.56	22902405
1164	Phosphorylation	GAKGFGFSLRGGREY CCCCCCEEECCCCEE	19.96	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAGI1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGI1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGI1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MAGI1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.