MADD_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MADD_RAT
• UniProt AC: O08873
• Protein Name: MAP kinase-activating death domain protein
• Gene Name: Madd {ECO:0000312|RGD:619922}
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 1602
• Subcellular Localization: Membrane . Cytoplasm.
• Protein Description: Plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. Component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. Plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis)..
• Protein Sequence: MVQKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRMPKEKAEGGAGPRGKEGAHAPCASEEAATESSESGSTLQPPSADSTPDVNQSPRGKRRAKAGNRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKPGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQEVQQALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQETPLLLGRFSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAEKLARTQAVEYFGEWILNPSNYAFQRIHNNTFDPALIGDKPKWYAHQLQPIHYRVYDSNSQLAEALSVPPERDSESDPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQPQKEGEEPGPDSENSQENLPLRSSSSTTASSSPSTIVHGAHSEPADSTEVGDKAATGISKPLPPVPPSICKSTVDRRQTETGEGSVCQRTYDHPYFEPQYGSPAEEDDDEQGESYTPRFSQHASGSRAQKLLRPNSLKLASDSDAESDSRASSPNSTVSNNSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKTTPFPSLKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLSRAVQSEDDARQDVIQDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTENVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGRGPKELDTRSLKEENFVASVGPEVIKPVFDLGETEEKKSQISADSGVSLASASQRTDQDSVIGVSPAVMIRSSSQDSEVSNSSGETLGADSDLSSNAGDGPGGEGSAHLASSRATLSDSEIETNSATSTIFGKAHSLKPKEKPASSPVRSSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHVGLVYSQQINEVLDQLTNLNGRDLSIRSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVRSSEEDLRTPPRPVSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
145	Phosphorylation	GSTLQPPSADSTPDV CCCCCCCCCCCCCCC	51.93	27097102
148	Phosphorylation	LQPPSADSTPDVNQS CCCCCCCCCCCCCCC	41.37	27097102
149	Phosphorylation	QPPSADSTPDVNQSP CCCCCCCCCCCCCCH	24.85	27097102
155	Phosphorylation	STPDVNQSPRGKRRA CCCCCCCCHHHHHHH	16.03	23589303
424	Ubiquitination	EPESLELKKHLKQAL CCCHHHHHHHHHHHH	28.86	-
540	Ubiquitination	RQTPFAEKLARTQAV CCCCHHHHHHHCHHH	43.98	-
688	Phosphorylation	GEEPGPDSENSQENL CCCCCCCCCCCCCCC	41.64	28432305
691	Phosphorylation	PGPDSENSQENLPLR CCCCCCCCCCCCCCC	34.52	28432305
701	Phosphorylation	NLPLRSSSSTTASSS CCCCCCCCCCCCCCC	32.71	30240740
706	Phosphorylation	SSSSTTASSSPSTIV CCCCCCCCCCCCEEE	29.29	30181290
707	Phosphorylation	SSSTTASSSPSTIVH CCCCCCCCCCCEEEC	43.75	28432305
708	Phosphorylation	SSTTASSSPSTIVHG CCCCCCCCCCEEECC	22.00	28432305
710	Phosphorylation	TTASSSPSTIVHGAH CCCCCCCCEEECCCC	32.49	28432305
711	Phosphorylation	TASSSPSTIVHGAHS CCCCCCCEEECCCCC	30.33	28432305
776	Phosphorylation	HPYFEPQYGSPAEED CCCCCCCCCCCCCCC	30.22	28432305
778	Phosphorylation	YFEPQYGSPAEEDDD CCCCCCCCCCCCCCC	18.92	23589303
812	Phosphorylation	QKLLRPNSLKLASDS HHHHCCCCCEECCCC	29.57	29779826
817	Phosphorylation	PNSLKLASDSDAESD CCCCEECCCCCCCCC	48.35	25403869
819	Phosphorylation	SLKLASDSDAESDSR CCEECCCCCCCCCCC	35.90	22108457
823	Phosphorylation	ASDSDAESDSRASSP CCCCCCCCCCCCCCC	42.48	28432305
825	Phosphorylation	DSDAESDSRASSPNS CCCCCCCCCCCCCCC	38.74	28432305
828	Phosphorylation	AESDSRASSPNSTVS CCCCCCCCCCCCCCC	45.26	22673903
829	Phosphorylation	ESDSRASSPNSTVSN CCCCCCCCCCCCCCC	27.41	22673903
832	Phosphorylation	SRASSPNSTVSNNST CCCCCCCCCCCCCCC	33.30	22673903
833	Phosphorylation	RASSPNSTVSNNSTE CCCCCCCCCCCCCCC	34.29	22673903
835	Phosphorylation	SSPNSTVSNNSTEGF CCCCCCCCCCCCCCC	30.31	22673903
857	Phosphorylation	SSLYRNHSTSFSLSN HHHHHCCCCCCEECC	29.33	28432305
858	Phosphorylation	SLYRNHSTSFSLSNL HHHHCCCCCCEECCC	26.66	28432305
859	Phosphorylation	LYRNHSTSFSLSNLT HHHCCCCCCEECCCC	18.82	28432305
861	Phosphorylation	RNHSTSFSLSNLTLP HCCCCCCEECCCCCC	30.56	25403869
863	Phosphorylation	HSTSFSLSNLTLPTK CCCCCEECCCCCCCC	28.70	28432305
866	Phosphorylation	SFSLSNLTLPTKGAR CCEECCCCCCCCCCC	34.64	28432305
869	Phosphorylation	LSNLTLPTKGAREKT ECCCCCCCCCCCCCC	45.26	28432305
894	Phosphorylation	RALVDQKSSVIKHSP CHHCCCCCHHHCCCC	24.97	28432305
895	Phosphorylation	ALVDQKSSVIKHSPT HHCCCCCHHHCCCCC	34.59	28432305
900	Phosphorylation	KSSVIKHSPTVKREP CCHHHCCCCCCCCCC	19.77	28432305
902	Phosphorylation	SVIKHSPTVKREPPS HHHCCCCCCCCCCCC	41.49	28432305
909	Phosphorylation	TVKREPPSPQGRSSN CCCCCCCCCCCCCCC	40.34	22108457
961	Acetylation	LRVFVLSKLSRAVQS HHHHHHHHHHHHHCC	46.45	22902405
1038	Phosphorylation	EPDKRKRSPTENVNT CCCCCCCCCCCCCCC	38.93	30411139
1040	Phosphorylation	DKRKRSPTENVNTPV CCCCCCCCCCCCCCC	41.25	30411139
1045	Phosphorylation	SPTENVNTPVGKDPG CCCCCCCCCCCCCCC	18.31	30411139
1089	Phosphorylation	PKELDTRSLKEENFV CCCCCCCCHHHHCCC	45.98	-
1135	Phosphorylation	LASASQRTDQDSVIG CCCCCCCCCCCCCCC	30.30	28432305
1139	Phosphorylation	SQRTDQDSVIGVSPA CCCCCCCCCCCCCCE	15.25	28432305
1144	Phosphorylation	QDSVIGVSPAVMIRS CCCCCCCCCEEEEEC	11.26	28432305
1194	Phosphorylation	HLASSRATLSDSEIE HHHHCCCCCCHHHHC	26.19	27097102
1196	Phosphorylation	ASSRATLSDSEIETN HHCCCCCCHHHHCCC	34.43	23984901
1198	Phosphorylation	SRATLSDSEIETNSA CCCCCCHHHHCCCCC	36.78	27097102
1202	Phosphorylation	LSDSEIETNSATSTI CCHHHHCCCCCCCEE	39.88	27097102
1224	Phosphorylation	KPKEKPASSPVRSSE CCCCCCCCCCCCCCC	43.64	28432305
1225	Phosphorylation	PKEKPASSPVRSSED CCCCCCCCCCCCCCC	29.53	28432305
1229	Phosphorylation	PASSPVRSSEDVSQR CCCCCCCCCCCHHHH	38.01	22673903
1230	Phosphorylation	ASSPVRSSEDVSQRV CCCCCCCCCCHHHHH	27.53	22673903
1234	Phosphorylation	VRSSEDVSQRVYLYE CCCCCCHHHHHHHHH	25.29	22673903
1480	Phosphorylation	LYYCVKDSMERAAAR HHHHHHHHHHHHHHH	19.47	26022182
1595	Phosphorylation	SSEEDLRTPPRPVSS CCHHHHCCCCCCCCC	44.96	30240740

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MADD_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MADD_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MADD_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of MADD_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.