MADD_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MADD_DROME
• UniProt AC: Q9VXY2
• Protein Name: MAP kinase-activating death domain protein
• Gene Name: Rab3-GEF {ECO:0000312|FlyBase:FBgn0030613}
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 2084
• Subcellular Localization: Membrane. Cytoplasm.
• Protein Description: Plays significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. Plays an important regulatory role in physiological cell death, caspase-mediated apoptosis (By similarity). Converts GDP-bound inactive form of Rab3 to the GTP-bound active forms..
• Protein Sequence: MSDQQKASLCPRLVDYMAIVGAHTTPPMPKGLQGLKAPPVQVPDLLRRYPPSDHADFPLPLDMVYFCQPEGCTSVGPRRTGSAIRDMTSFVFALTDKDSGKTRYGICVNFYRPIERPSSAAGSAGAGNDRPGNGGPGGHGGGAGGGAGGGGRGGRRSSAFRRESWRKSMERSSDSAFSSDYRSNVAPSDSDRELTSRRDSDQQRLHSHHSHHQPHHPSASPAVPKLGLMAPSADSESGGSHSPSPRASRKRTKLRNQSLTSLCIISHHPFFTTFRECLFILKKLIDACNESSSPKRVGASQKINRDNVWTVLTGHVSDATPSIVLHDVREIETWILRLLSTPVPVPGSTRVEVEVLSPTVHEPLLFALPDHTRFSLVDFPLHLPLELLGVETCLKVWTLIMQENKVLFQSRDYNALSMSVMAFVTMLYPLEYMFPVIPLLPTCLSCAEQLLLAPTPFVIGVPASFLVYKKNFRLPDDIWVVDLDSTKLTPPTGGYEEIPPLPEPEGTILKNHLKQALTSMTATNTAVSSQQLLPSVRDSLQEPPLLGVSQVRLPLQTPPHSAQASQRNSMSAQGTISSRQPSPMNSPALNPFVYGTDVDSVDVATRVAMVRFFNAQNTLANFAEHTRTLRLYPRPVVAFQINSFLRSRPRASQFLNQFARTQAVEFLAEWSLTPTNVAFLRVQTGVMDPMQVGDKPKWFAHALTPIRFSVWDDGSSLNGALRSLKQLECQPTDESGSDSEGADSSSSSYSSLSDFVSEMASSDLSPSLHDVFGSYNRPHVVPQTLSSNLDPALVYHPPSKLQYPEGIADAVASKEEEDEERADSPVSSSSSRSDLSSPSFNRDSEFDFQPKGGQTLGSTTVGSGAAAPSFELATPLAMRLEATIKMASIEQESDTVSTATGKTIAAGSKLQRHPSDSESRPEKKIPPPLTPPVKQPGVSNILARTGSSGSSSSSPGRQSSQSSLFENFASHAKELVRETTRQSSQEGLLAHVDKFTLHAKKAAGEASKQALEVSKQAAGVSKNTLEDLTYVGKSTLGDLTKTAKEAATKKGIIKIEEHSAGGAGPPPKSPGSQLATHKQVQQSGGQGGGNNFFSAIGTDFNGLASSTSTMFSGMFGKKSQQKQVPVQQKQPNVSAGKAKSGINFDPFPGRKGLVERTPLIKHSGPRQTQEELTRQQNQERSHSNAENQTFLKDVTNQVLAGEGVGWLKLNRFKKLMEDESYRTLVLSKLNKTLDKKIAPDDHIDDVCVTKPVWKGMLKCIQAIAGGLDVTFANFGLGGMASVFQLMEVAHTHYWSKEINEGSDMSSSLLSSHAASPMGSRENLRSPSSPNGSHSALGSEWASPQESRKSSTQLAHGGPGGSHSGAPINRRLSSADSQDGQSTTEMFKDMLSQKRSALKNMLTSFDSDTTTSKDSKKSSGNLWSGKSTLSAGFRYTGGHLINTSSSPSPDSPRVYLFEGLLGKDRLNLWNQMQFWEDAFLDAVSQERDMIGMDQGPIEMMERYKSLSESERKRLEHDEDRLLSTMLYNLTAILVMLNVAKDEIRRKIRRLLGKSHIGLVYSQEVHNVVDQINNLNGNDIDLKPLGSRLLHRQSFTVHQGTDVNGPLRFMEVRDDGLVLRSVDGTIVERWWYERLVNMTYSPKTKLLCLWRRNGGQTQLHKYYTRKCKELYNCIKEAMERGGTPTNVPELGGEFPVQDMNTGEGGLLQVCLEGVGLLFSNSKFFVRLDHIRKCFTQKGGIFVLEEYNPKTRNLIQRKYQSSMSDQICYSVLCVFSYVAAGQDQKKNPVVITPQIQDIHAQQKQKHQQQQQHQQPQQQQQPHQTTTQQNQPTAVASAVPTTTAPAGQVNPNRMTAKSQAGSISIRHTVPMQKPTITMSTVQPQARMPAQVATASVPVTVPVPPTPAPPTSNPAKLPQLPPRVPSQPSTESLASISSPPPKLRTPMSAPPGPPPAIPPRTGAISRSGSVPAARSFVRQASANSTPPQYTPQPPPPFVIPKRHSGLARASTLSSSTSPSMSSSSASNHPGHSQSQQRASHGSVAAVLQSMPEAEPGYGSGSGSISGSSSGSGSASGSIASASPQAHRKH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
292	Phosphorylation	IDACNESSSPKRVGA HHHHCCCCCCCCCCC	2.45	27794539
293	Phosphorylation	DACNESSSPKRVGAS HHHCCCCCCCCCCCC	22.18	27794539
888	Phosphorylation	EATIKMASIEQESDT HHHEEECCHHCCCCC	17.79	27794539
915	Phosphorylation	SKLQRHPSDSESRPE CCHHCCCCCCCCCCC	46.27	27794539
979	Phosphorylation	AKELVRETTRQSSQE HHHHHHHHHHHCCHH	6.71	27794539
983	Phosphorylation	VRETTRQSSQEGLLA HHHHHHHCCHHHHHH	34.95	27794539
984	Phosphorylation	RETTRQSSQEGLLAH HHHHHHCCHHHHHHH	7.24	27794539
1403	Phosphorylation	ALKNMLTSFDSDTTT HHHHHHHHCCCCCCC	65.02	27794539

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MADD_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MADD_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MADD_DROME !!

Protein-Protein Interaction

Oops, there are no PPI records of MADD_DROME !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.